Guanabana Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Guanabana Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Guanabana Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guanabana Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Guanabana Extract by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with Guanabana Extract by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Guanabana Extract by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: guanabana fruit extract (also called graviola). It's derived from the guanabana fruit and is the only component we're looking at here.
There are no inactive fillers or other ingredients in this formula—it's the extract on its own.
Does it work?
Couldn't assess
The evidence we hold doesn't establish that guanabana extract works for the conditions it's marketed for. Its effectiveness is rated as insufficient reliable evidence for human papillomavirus (HPV), headache, and as an insect repellent, and similarly for male infertility.
That means the research backing it up isn't there yet, or it's too limited to draw conclusions.
How safe is it?
Well-documented data
Here's where you need to pay attention: regular use of guanabana may not be safe. Lab studies raise concerns about possible nerve toxicity with long-term use, and the safety data in humans are limited.
The most common side effects reported in a clinical trial were nausea and burning pain in the upper abdomen after taking 300 mg daily. Rarely, it's been linked to movement disorders and myeloneuropathy (nerve damage)—symptoms similar to Parkinson disease.
A large observational study found that even low cumulative amounts of guanabana fruit, juice, or herbal tea were tied to worsened motor and cognitive symptoms in people with Parkinson disease. Guanabana is rated possibly unsafe in pregnancy and should be avoided while breastfeeding due to insufficient safety data.
If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before using this product.
Meds to double-check
Moderate interaction found
If you take carbamazepine (Tegretol) or any anti-seizure medication, check with your pharmacist before using this product. Guanabana may lower carbamazepine levels in your blood, which could weaken seizure control.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Guanabana extract may interest people looking for traditional remedies, but the evidence for its effectiveness is weak across the board. The safety concerns—especially the risk of nerve damage and movement problems with regular use—and the interaction with carbamazepine mean you should have a careful conversation with your pharmacist before starting it.
If you take any seizure medications or have Parkinson disease, this product is not a good fit.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Guanabana Extract, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X001EXCYRZ |
| Net contents | 250 Gram(s); 8.8 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | May 23, 2024 |
| DSLD ID | 312793 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Guanabana Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Guanabana Fruit Extract | 500 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
BulkSupplements.com Clean & pure bulk supplements
Formulation
Color may vary
Free of: Added sugar, soy, dairy, yeast, gluten, additives
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 500 mg (about 1/5 tsp) one to three times daily, or as directed by a physician.
Storage
Contents sold by weight, not volume. Settling may occur. Store in a dry, cool place
General Statements
Use an accurate milligram scale. New
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Guanabana Extract by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Guanabana Extract by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size500 mg Dosage formPowder Servings per container500 Amounts shown are per serving.
Guanabana Fruit Extract
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Guanabana Fruit Extract monograph & interactionsGuanabana Extract by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
Guanabana Extract by BulkSupplements.com contains one active ingredient—guanabana fruit extract—that we've checked for drug interactions.
It interacts with one medication: carbamazepine (Tegretol), an anti-seizure drug. A rat study found that guanabana extract reduced carbamazepine levels in the bloodstream by 46% at peak concentration and 35% overall, which could make the medication less effective at controlling seizures.
Read the full breakdown — every affected drug type, severity by severity
If you take carbamazepine, do not start this supplement without talking to your doctor or pharmacist first. They'll need to know because this interaction could affect how well your seizure control works.
Use the medication checker on this page to verify your exact prescriptions before you begin.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Guanabana Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Guanabana Extract interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Guanabana Extract interact with drugs. Each result below shows which ingredient is responsible. Guanabana Fruit Extract
CarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Guanabana Extract — through 1 ingredient. Tap an ingredient for the detail:
Guanabana Fruit ExtractCarbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
Read the full Guanabana Fruit Extract + Carbamazepine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Guanabana Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Guanabana Fruit Extract
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Guanabana Extract, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
Guanabana Extract by BulkSupplements.com: Common Questions
Does Guanabana Extract by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the most common side effects?
Does this product actually work for anything?
Should I worry about long-term use?
Is this safe if I have Parkinson disease?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Guanabana Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Guanabana Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Guanabana Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC