Hair, Skin and Nails Ingredients & Drug Interactions
by Dr. Mercola
What is this page for?
First and foremost: checking Hair, Skin and Nails against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Hair, Skin and Nails is a dietary supplement by Dr. Mercola with 3 active ingredients. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Hair, Skin and Nails by Dr. Mercola
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This capsule contains three active ingredients: biotin, keratin, and hyaluronic acid. Biotin is a B vitamin, and hyaluronic acid is a substance the body naturally makes that helps hold moisture in the skin and eyes.
Keratin is a structural protein that is part of hair and nails. The inactive ingredients are hydroxypropyl methylcellulose, rice hull, rice extract, gum acacia, and sunflower oil.
These are fillers and capsule materials that don't add to the effect.
Does it work?
Strong evidence
For biotin, the evidence is likely effective for biotin deficiency. It is possibly ineffective for multiple sclerosis and for seborrheic dermatitis, and there isn't reliable evidence to rate it for alopecia areata.
Biotin's role in healthy hair and nails is not rated in the data we hold. For hyaluronic acid, the evidence is possibly effective for dry eye and for venous leg ulcers.
There isn't reliable evidence to rate it for aging skin, hay fever, or sexual dysfunction. We hold no effectiveness ratings for keratin.
How safe is it?
Well-documented data
Biotin is generally considered safe and well tolerated, even at fairly high doses, because the body clears the excess in urine. Mild diarrhea has been rarely associated with high-dose biotin.
One case report linked a serious inflammatory heart and lung reaction to a combination of biotin and pantothenic acid, but whether biotin was involved is unknown, and there have been no other similar reports. Our safety notes say high-dose products should be discussed with your doctor first.
Hyaluronic acid appears to be generally well tolerated by most adults when taken orally, but its long-term safety as a supplement is not fully studied. Our safety notes advise avoiding oral supplements unless your doctor advises otherwise.
We hold no safety data for keratin.
Meds to double-check
No known interactions
No interactions are documented in our data for biotin or hyaluronic acid. We could not check keratin, so we hold no interaction data for it.
Before taking this product, have your doctor or pharmacist review your full medication list, and use the search tool on this page for your specific medications.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
This product may interest adults looking for a biotin-based supplement for hair, skin, and nails, though the evidence for those specific uses is limited. If you take prescription medications, have a medical condition, or take high-dose biotin, talk it over with your own doctor or pharmacist before starting.
Our data doesn't cover keratin, so ask your healthcare provider about it too.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Hair, Skin and Nails, straight from the product label.
| Brand | Dr. Mercola |
|---|---|
| Barcode (UPC) | 810487032940 |
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 327170 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Hair, Skin and Nails by Dr. Mercola, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Biotin | 5000 mcg | 16667% |
| Keratin | 500 mg | -- |
| Hyaluronic Acid | 20 mg | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Rice hull, Rice extract, Gum Acacia, Sunflower Oil
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: Adults, as a dietary supplement, take one (1) capsule daily with a meal.
Precautions
Keep out of reach of children.
Do not use if safety seal is broken.
If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.
Formula
Biotin, Keratin & Hyaluronic Acid
FDA Statement of Identity
Dietary Supplement
General Statements
Providing quality products since 2001.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Hair, Skin and Nails by Dr. Mercola label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Hair, Skin and Nails by Dr. Mercola
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Biotin
No knowninteractions
Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...
Biotin monograph & interactionsKeratin
Hyaluronic Acid
No knowninteractions
Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...
Hyaluronic Acid monograph & interactionsOther (inactive) ingredients: Hydroxypropyl Methylcellulose, Rice hull, Rice extract, Gum Acacia, Sunflower Oil. These complete the product’s ingredient list but are not active constituents.
Hair, Skin and Nails by Dr. Mercola Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Hair, Skin and Nails. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Hair, Skin and Nails, from the product label.
Dr. Mercola
See all Dr. Mercola products- Name
- NHP
- Street Address
- 125 SW 3rd Place
- City
- Cape Coral
- State
- FL
- ZipCode
- 33991
- Phone Number
- (877) 985-2696
Hair, Skin and Nails by Dr. Mercola: Common Questions
Does Hair, Skin and Nails by Dr. Mercola interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this product safe during pregnancy?
What are the side effects of biotin?
Does hyaluronic acid work for dry eye?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Hair, Skin and Nails is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Hair, Skin and Nails’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Biotin
Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...
Read the full Biotin monograph → Herb & supplement monographHyaluronic Acid
Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...
Read the full Hyaluronic Acid monograph →Sources & How We Checked
Hair, Skin and Nails's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 8 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Biotin 4 references
- Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
- Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed
Hyaluronic Acid 4 references
- Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
- U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
- Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
- Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC