Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Herbal Diuretic Ingredients & Drug Interactions

by Nature's Harmony

Herbal Diuretic label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Herbal Diuretic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Herbal Diuretic is a dietary supplement by Nature's Harmony with 5 active ingredients. Its ingredients are commonly taken for high blood pressure, fluid retention (diuretic), joint pain and inflammation.Based on those ingredients, 1,349 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uva Ursi (Arctostaphylos uva-ursi) leaf 3:1 extract, Celery, Buchu (Barosma betulina) leaf 4:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Herbal Diuretic by Nature's Harmony

Ask about any prescription or over-the-counter medication and we check it for interactions with Herbal Diuretic by Nature's Harmony — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Herbal Diuretic by Nature's Harmony

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Nature's Harmony Herbal Diuretic contains five active herbal ingredients: celery, parsley, uva ursi leaf (a concentrated 3:1 extract), buchu leaf (a concentrated 4:1 extract), and juniper fruit (a concentrated 4:1 extract). These are traditional plant-based diuretics — substances meant to increase urine production.

The product also contains inactive ingredients: microcrystalline cellulose (a binder), silicon dioxide (an anti-caking agent), magnesium stearate (a lubricant), and gelatin (the capsule material).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: promotes excretion of water.
  • We looked for evidence on: Urinary tract infections (UTIs), Kidney stones (nephrolithiasis), fluid retention, edema, water retention.
  • The closest evidence on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs) (Natural Medicines).
  • Also on file: Juniper is rated "Insufficient Reliable Evidence To Rate" for Kidney stones (nephrolithiasis), Urinary tract infections (UTIs).
  • Also on file: Parsley is rated "Insufficient Reliable Evidence To Rate" for Kidney stones (nephrolithiasis), Urinary tract infections (UTIs).

The evidence supporting these ingredients for their intended uses is limited. For celery, parsley, buchu, and juniper, the data we hold shows insufficient reliable evidence to rate their effectiveness for the conditions they're traditionally used for — including urinary tract infections and diuretic effects.

Uva ursi is rated possibly ineffective for urinary tract infections despite its traditional use. Clinical research does suggest that celery seed extract may lower daytime blood pressure by about 12 mmHg, which is more substantial than placebo, but this is a side effect rather than the product's main purpose.

The evidence, ingredient by ingredient Celery Parsley Uva Ursi Buchu Juniper

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Celery and parsley are generally well tolerated when used in food amounts, though concentrated supplements carry allergy risk — oral allergy syndrome (itching and burning in the mouth and throat) is most common, but anaphylaxis has been reported in sensitive individuals. Uva ursi is generally well tolerated in low doses short-term but can cause nausea, vomiting, diarrhea, and stomach upset; high doses (20 grams or more) have been linked to serious effects like convulsions and delirium.

Buchu lacks established adverse effect data in our records but contains pulegone, a known liver toxin. Juniper may irritate the kidneys and should not be used long-term.

All five ingredients are rated likely unsafe or unsafe in pregnancy due to potential uterine effects; celery and parsley advise against medicinal amounts during pregnancy, while uva ursi, buchu, and juniper should be avoided entirely. Lactation safety data is insufficient for all ingredients except buchu, which is rated possibly safe — talk with your doctor or pharmacist before using while breastfeeding.

Side effects, ingredient by ingredient Celery Parsley Uva Ursi Buchu Juniper

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Buchu, Uva Ursi, Juniper, Parsley, Celery.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,350 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Nature's Harmony Herbal Diuretic, check with your doctor or pharmacist if you take any blood thinners (anticoagulants or antiplatelet drugs like warfarin, aspirin, or clopidogrel), lithium, thyroid medication (levothyroxine), diabetes drugs, blood pressure medications, antidepressants (especially venlafaxine), diuretics, or any drug metabolized by the liver. The product interacts with all of these drug types at moderate or minor severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product contains five herbal diuretics, none of which have strong evidence supporting their effectiveness for the conditions they're traditionally used for, and all carry interactions with medications — especially blood thinners, diabetes drugs, and lithium. If you take any prescription medications, check them against the search tool on this page before starting.

Pregnant or breastfeeding individuals should not use this product without first discussing it with their doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Herbal Diuretic, straight from the product label.

Brand Nature's Harmony
Net contents 250 Capsule(s)
Market status On market
Date entered into DSLD May 24, 2013
DSLD ID 21725
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Herbal Diuretic by Nature's Harmony, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
5 Capsule(s)
IngredientAmount% DV
Celery75 mg--
Parsley75 mg--
Uva Ursi (Arctostaphylos uva-ursi) leaf 3:1 extract33.3 mg--
Buchu (Barosma betulina) leaf 4:1 extract25 mg--
Juniper (Juniperus communis) fruit 4:1 extract25 mg--

Other ingredients: Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Promotes Excretion of Water

{Capsule} Actual Size

A Proud Canadian Company

UPC CODE TO BE: 0 63047 05883 0

Suggested/Recommended/Usage/Directions

Recommended Use: A traditional herbal medicine to promote excretion of water. Recommended Dose (Adults): Take 3 to 5 capsules three times per day. May be used for up to four weeks.

Precautions

Risk Information: Do not use if pregnant, breastfeeding, have kidney disease or gastrointestinal inflammation/infection.

Consult a health care practitioner before use if you have high blood pressure or diabetes. Discontinue use if skin irritation occurs.

KEEP OUT OF REACH OF CHILDREN.

DO NOT USE IF SEAL UNDER CAP IS BROKEN.

Formulation

This product does not contain corn, dairy, egg, gluten, shellfish, soy, sulfites, wheat or artificial colours, flavours or preservatives.

Storage

STORE IN A COOL, DRY PLACE.

FDA Statement of Identity

Traditional Herbal Medicine

General

4003242.01-02

Seals/Symbols

SunOpta A healthy products company

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Herbal Diuretic by Nature's Harmony label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Herbal Diuretic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Herbal Diuretic by Nature's Harmony

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Celery

Interacts with
651 drugs
75 mg per serving

Celery is a common vegetable that is also taken as a seed extract or oil supplement, mainly for blood pressure, fluid retention, and joint discomfort....

Celery monograph & interactions

Parsley

Interacts with
443 drugs
75 mg per serving

Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C. It is traditionally used as a...

Parsley monograph & interactions

Uva Ursi (Arctostaphylos uva-ursi) leaf 3:1 extract

Interacts with
803 drugs
33.3 mg per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Uva Ursi (Arctostaphylos uva-ursi) leaf 3:1 extract monograph & interactions

Buchu (Barosma betulina) leaf 4:1 extract

Interacts with
481 drugs
25 mg per serving

Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies...

Buchu (Barosma betulina) leaf 4:1 extract monograph & interactions

Juniper (Juniperus communis) fruit 4:1 extract

Interacts with
162 drugs
25 mg per serving

Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its he...

Juniper (Juniperus communis) fruit 4:1 extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Herbal Diuretic by Nature's Harmony Drug Interactions

Want to check YOUR meds against Herbal Diuretic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,349Drugs
1,224 Moderate 125 Minor

Ingredients driving the most interactions

Uva Ursi (Arctostaphylos uva-ursi) leaf 3:1 extract 803
Celery 651
Buchu (Barosma betulina) leaf 4:1 extract 481
Parsley 443
Juniper (Juniperus communis) fruit 4:1 extract 162

Individual Drug Interactions

The ingredients in Herbal Diuretic interact with 1,349 drugs. Click any drug to see the details.

5 of the 5 ingredients in Herbal Diuretic interact with drugs. Each result below shows which ingredient is responsible. Uva Ursi (Arctostaphylos uva-ursi) leaf 3:1 extract Celery Buchu (Barosma betulina) leaf 4:1 extract Parsley Juniper (Juniperus communis) fruit 4:1 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Herbal Diuretic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Uva Ursi (Arctostaphylos uva-ursi) leaf 3:1 extract6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Uva Ursi (Arctostaphylos uva-ursi) leaf 3:1 extract full monograph & interactions

Celery8 drug types · 651 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Celery root contains the constituents falcarinol and falcarindiol. Laboratory research suggests that these constituents can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, celery seed extract might have additive effects with antihypertensive drugs.
Clinical research suggests that taking celery seed extract may reduce daytime systolic blood pressure by about 12 mmHg compared to less than 1 mmHg with placebo.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggests that constituents of celery can inhibit CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Levothyroxine (Synthroid, Others)

Theoretically, celery seed might decrease the effects of levothyroxine.
Several cases of hypothyroidism with low T4 levels have been reported in people who were previously stabilized on levothyroxine and then started taking celery seed tablets. They presented with symptoms such as lethargy, bloating, and dry skin, and recovered when celery seed was stopped. However, celery stem and leaf has been associated with case reports of hyperthyroidism in patients with no pre-existing thyroid disorders.

Likelihood Possible Evidence D
Lithium

Theoretically, celery might reduce excretion and increase levels of lithium due to potential diuretic effects.
Celery is thought to have diuretic properties. However, this effect has not been confirmed in humans.

Likelihood Probable Evidence D
Venlafaxine (Effexor)

Theoretically, celery root extract might increase blood levels of venlafaxine.
There is one case report of a patient who experienced medication-induced bipolar disorder after beginning to take celery root extract 1000 mg daily along with venlafaxine 75 mg and St. John's wort 600 mg daily. Symptoms included confusion, speech abnormalities, manic affect, and visual hallucinations. The plasma level of venlafaxine was 476.8 ng/mL (normal range 195-400 ng/mL). It is theorized that celery root increased venlafaxine levels by inhibiting cytochrome P450 2D6.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Theoretically, celery juice might increase the effects and side effects of acetaminophen.
Animal research suggests that concomitant use of celery juice plus acetaminophen prolongs the effects of acetaminophen. This effect has been attributed to a decrease in hepatic cytochrome P450 activity. However, other animal research shows that pretreatment with celery root extract protects against acetaminophen-induced acute liver failure. These effects have not been reported in humans.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Laboratory research shows that celery contains photosensitizing agents such as phenols and psoralens.

Likelihood Possible Evidence D
Celery full monograph & interactions

Buchu (Barosma betulina) leaf 4:1 extract3 drug types · 481 drugs

Anticoagulant/Antiplatelet Drugs

Buchu may have antiplatelet effects. Theoretically, buchu may enhance the effects of anticoagulant or antiplatelet drugs and increase the risk of bleeding in some patients. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Buchu contains pulegone, a known hepatotoxin. There is some concern that buchu may adversely affect the liver, especially when the leaf is used in large doses or the oil is ingested. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of liver damage. Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (Tricor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo)

Likelihood Possible Evidence D
Lithium

Buchu is thought to have diuretic properties. Theoretically, buchu might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Buchu (Barosma betulina) leaf 4:1 extract full monograph & interactions

Parsley8 drug types · 443 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Animal research suggests that parsley has antiplatelet effects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that parsley might decrease blood glucose. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Laboratory research suggests that parsley can inhibit CYP1A2.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.
Animal research suggests that parsley seed extract increases urine elimination. Parsley leaf and root might also interfere with diuretic therapy due their purported aquaretic effects.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, parsley might increase the duration of pentobarbital effects.
Animal research suggests that parsley juice prolongs the action of pentobarbital, perhaps by decreasing cytochrome P450 levels. It is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
Sirolimus (Rapamune)

Theoretically, large quantities of parsley might increase sirolimus levels.
In one case report, an adult female with a history of kidney transplant presented with elevated blood sirolimus levels, approximately 4-7 times greater than previous measures, after daily consumption of a juice containing approximately 30 grams of parsley for 7 days. Sirolimus levels returned to normal a week after the parsley juice was discontinued.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, large amounts of parsley leaf and root might decrease the effects of warfarin.
Parlsey contains vitamin K.

Likelihood Possible Evidence D
Aspirin

Theoretically, aspirin might increase the severity of allergic reactions to parsley.
In one case, severe urticaria and swelling were reported after taking aspirin with parsley in an individual with a known mild parsley allergy.

Likelihood Unlikely Evidence D
Parsley full monograph & interactions

Juniper (Juniperus communis) fruit 4:1 extract3 drug types · 162 drugs

Antidiabetes Drugs

Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Animal research shows that juniper berry can lower blood glucose.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Juniper berry is thought to have mild diuretic effects.

Likelihood Possible Evidence D
Lithium

Theoretically, juniper berry might reduce lithium excretion and increase serum levels of lithium.
Juniper berry is thought to have mild diuretic effects.

Likelihood Possible Evidence D
Juniper (Juniperus communis) fruit 4:1 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Herbal Diuretic, from the product label.

Nature's Harmony

See all Nature's Harmony products
Name
SunOpta Inc.
Street Address
6 Commerce Crescent
City
Acton
State
ON
ZipCode
L7J 2X3
Pharmacist Counseling Corner

Herbal Diuretic by Nature's Harmony: Common Questions

Does Herbal Diuretic by Nature's Harmony interact with any medications?
Yes. Based on its ingredients, Herbal Diuretic has a known interaction with 1,349 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Herbal Diuretic contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No. All five active ingredients in this product are rated likely unsafe or unsafe during pregnancy because they may affect the uterus. If you are pregnant or planning to become pregnant, talk with your doctor or pharmacist before taking any herbal diuretic product.
Is this product safe to use long-term?
The data we hold does not support long-term use. Uva ursi is flagged as potentially toxic with prolonged use, and juniper is specifically cautioned against long-term use because it may irritate the kidneys. Talk with your doctor or pharmacist about safe duration for your situation.
What does this product actually do?
These are traditional herbal diuretics meant to increase urine production. However, the evidence supporting their effectiveness is insufficient or possibly ineffective — uva ursi for urinary tract infections is rated possibly ineffective. The only measurable effect we have data for is celery's modest blood pressure reduction, which is a side effect, not the intended use.
What are the most common side effects?
Celery and parsley can cause oral allergy syndrome (itching and burning in the mouth and throat) in sensitive people. Uva ursi may cause nausea, vomiting, diarrhea, and stomach upset. Juniper may irritate the skin or kidneys. Anaphylaxis is rare but has been reported with celery and parsley in allergic individuals.
Can I take this with my blood pressure medication?
Possibly not without adjustment. Celery extract may lower blood pressure on its own and could add to the effects of your medication. Talk with your doctor or pharmacist before combining them, as your blood pressure medication dose might need to be changed.
What if I'm allergic to celery or parsley?
Do not take this product. Celery and parsley allergies can be serious, ranging from oral allergy syndrome to anaphylaxis. Check the full ingredient list carefully, and if you have a known allergy to any ingredient, avoid this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Herbal Diuretic label
Go deeper

The Full Monographs Behind Herbal Diuretic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Celery

Interacts with 651 drugs

Celery is a common vegetable that is also taken as a seed extract or oil supplement, mainly for blood pressure, fluid retention, and joint discomfort. Human evidence for these supplement use...

Read the full Celery monograph → Herb & supplement monograph

Parsley

Interacts with 443 drugs

Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C. It is traditionally used as a diuretic and for digestion, but solid hu...

Read the full Parsley monograph → Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph → Herb & supplement monograph

Buchu

Interacts with 481 drugs

Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies are lacking, so its benefits are largely...

Read the full Buchu monograph → Herb & supplement monograph

Juniper

Interacts with 162 drugs

Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its health benefits is limited, and it can irr...

Read the full Juniper monograph →
Sources

Sources & How We Checked

Herbal Diuretic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 87 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Celery 48 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
  5. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
  6. Moses, G. Thyroxine interacts with celery seed tablets? Australian Prescriber 2001;24:6-7. DOI
  7. Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
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See these in context on the Celery monograph →

Parsley 21 references
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  10. Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
  11. Jakovljevic, V., Raskovic, A., Popovic, M., and Sabo, J. The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism. Eur.J Drug Metab Pharmacokinet. 2002;27(3):153-156. PubMed
  12. Kreydiyyeh, S. I. and Usta, J. Diuretic effect and mechanism of action of parsley. J Ethnopharmacol 2002;79(3):353-357. PubMed
  13. Yanardag, R., Bolkent, S., Tabakoglu-Oguz, A., and Ozsoy-Sacan, O. Effects of Petroselinum crispum extract on pancreatic B cells and blood glucose of streptozotocin-induced diabetic rats. Biol Pharm Bull. 2003;26(8):1206-1210. PubMed
  14. Bolkent, S., Yanardag, R., Ozsoy-Sacan, O., and Karabulut-Bulan, O. Effects of parsley (Petroselinum crispum) on the liver of diabetic rats: a morphological and biochemical study. Phytother.Res 2004;18(12):996-999.
  15. Ozsoy-Sacan, O., Yanardag, R., Orak, H., Ozgey, Y., Yarat, A., and Tunali, T. Effects of parsley (Petroselinum crispum) extract versus glibornuride on the liver of streptozotocin-induced diabetic rats. J Ethnopharmacol 3-8-2006;104(1-2):175-181. PubMed
  16. Peterson, S., Lampe, J. W., Bammler, T. K., Gross-Steinmeyer, K., and Eaton, D. L. Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. Food Chem.Toxicol. 2006;44(9):147 PubMed
  17. Gadi, D., Bnouham, M., Aziz, M., Ziyyat, A., Legssyer, A., Legrand, C., Lafeve, F. F., and Mekhfi, H. Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats. J Ethnopharmacol 8-17-2009;125(1):170-174. PubMed
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  21. Kurtaran M, Koc NS, Aksun MS, Yildirim T, Yilmaz SR, Erdem Y. Petroselinum crispum, a commonly consumed food, affects sirolimus level in a renal transplant recipient: a case report. Ther Adv Drug Saf 2021;12:20420986211009358.

See these in context on the Parsley monograph →

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
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  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
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See these in context on the Uva Ursi monograph →

Buchu 3 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
  3. Moolla A, Viljoen AM. 'Buchu' - Agathosma betulina and Agathosma crenulata (Retaceae): a review. J Ethnopharmacol 2008;119(3):413-9.

See these in context on the Buchu monograph →

Juniper 7 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  5. Sanchez de Medina F, Gamez MJ, Jimenez I, et al. Hypoglycemic activity of juniper "berries." Planta Med 1994;60:197-200. PubMed
  6. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. PubMed
  7. Tammaro A, Adebanjo GAR, Chello C, et al. Bullous dermatitis caused by common juniper. Contact Dermatitis. 2020. PubMed

See these in context on the Juniper monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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