Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Hormone Protect Ingredients & Drug Interactions

by XYMOGEN

Hormone Protect label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hormone Protect against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hormone Protect is a dietary supplement by XYMOGEN with 2 active ingredients. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 270 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Diindolylmethane, TrueBroc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Hormone Protect by XYMOGEN

Ask about any prescription or over-the-counter medication and we check it for interactions with Hormone Protect by XYMOGEN — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Hormone Protect by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Hormone Protect contains 2 active ingredients: diindolylmethane, a compound derived from cruciferous vegetables, and TrueBroc, a broccoli extract. The product is made up as a capsule and includes inactive ingredients (hydroxypropyl methylcellulose, stearic acid, magnesium stearate, silica, and microcrystalline cellulose) that serve as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: promote healthy estrogen metabolism and detoxification.
  • We looked for evidence on: Premenstrual syndrome (PMS), Breast cancer, Cervical dysplasia, Uterine cancer, Prostate cancer, Benign prostatic hyperplasia (BPH) — and 4 related terms.
  • The closest evidence on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Breast cancer, Uterine cancer, Cervical dysplasia, Mastalgia, and more.

The evidence for diindolylmethane is not established in our data — we hold insufficient reliable evidence to rate it for benign prostate enlargement, breast cancer, uterine cancer, cervical dysplasia, colorectal cancer, or breast tenderness (mastalgia). Broccoli extract is possibly effective for colorectal cancer prevention, but evidence is insufficient to rate it for bladder cancer, breast cancer, prostate cancer, fibromyalgia, or gastric cancer.

The evidence, ingredient by ingredient Diindolylmethane Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Diindolylmethane is generally well tolerated in short-term studies, but long-term safety isn't well established. Common side effects include diarrhea, gas, headache, nausea, rash, and vomiting.

A rare serious reaction called DRESS (a drug rash with eosinophilia and systemic symptoms) has been reported. Because of possible hormone effects and limited safety data, diindolylmethane is best avoided during pregnancy and should not be used while breastfeeding.

Broccoli concentrate has not been studied extensively in pregnancy and lactation — though broccoli as food is likely safe, the data on concentrated supplements is limited, so check with your doctor or pharmacist. Broccoli extract may cause loose stools, diarrhea, abdominal pain, and cramping, especially at higher doses.

Side effects, ingredient by ingredient Diindolylmethane Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Diindolylmethane, Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 270 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using Hormone Protect if you take estrogen or hormone replacement therapy (diindolylmethane may interfere), water pills that lower sodium (Moderate risk of low blood sodium), or medications processed through CYP1A2 or CYP2A6 liver pathways (broccoli and diindolylmethane may reduce their effectiveness). Altogether, these interactions span 270 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product pairs two ingredients with documented interactions across a wide range of medications, especially hormone treatments, water pills, and certain drugs your liver metabolizes. If you take estrogen therapy, diuretics, or any prescription drugs, review your medication list with your own doctor or pharmacist before starting.

Long-term safety for both ingredients isn't well established, and the broccoli extract in particular hasn't been studied the way broccoli as food has been.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hormone Protect, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 871149004583
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 303700
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hormone Protect by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
871149004583
IngredientAmount% DV
Diindolylmethane300 mg--
TrueBroc60 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Stearic Acid, Magnesium Stearate, Silica, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

DIRECTIONS: Take one to two capsules daily, or as directed by your healthcare practitioner.

Precautions

Consult your healthcare practitioner prior to use.

Individuals taking medication or receiving cancer treatment should discuss potential interactions with their healthcare practitioner.

Do not use if tamper seal is damaged.

STORAGE: Keep tightly closed in a cool, dry place out of reach of children.

Formula

Hormone Protect is an ideal combination of DIM (diindolylmethane) and TrueBroc (glucoraphanin) that helps protect estrogen-sensitive tissues by promoting healthy estrogen metabolism and supporting detoxification and neutralization of harmful estrogen metabolites and xenoestrogens.

TrueBroc Powerful Antioxidant Properties

Estrogen Metabolism and Detoxification Support Formula

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

STORAGE: Keep tightly closed in a cool, dry place out of reach of children.

Formulation

DOES NOT CONTAIN: Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Vegetarian caps

Brand IP Statement(s)

TrueBroc is protected by trademarks and patents of Brassica Protection Products LLC: www.brassica.com/ip

Copyright 2019 XYMOGEN

Xymogen Exclusive professional formulas

Seals/Symbols

Vegetarian caps

ePV (ePedigree Verification)

GMP compliant third-party verified

FDA Statement of Identity

Dietary Supplement

General Statements

Scan to learn more! This package is completely recyclable

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hormone Protect by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hormone Protect label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hormone Protect by XYMOGEN

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Diindolylmethane

Interacts with
269 drugs
300 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Diindolylmethane monograph & interactions

TrueBroc

Interacts with
187 drugs
60 mg per serving Form: Broccoli Seed Extract

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

TrueBroc monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Stearic Acid, Magnesium Stearate, Silica, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hormone Protect by XYMOGEN Drug Interactions

Want to check YOUR meds against Hormone Protect?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
270Drugs
270 Moderate

Ingredients driving the most interactions

Diindolylmethane 269
TrueBroc 187

Individual Drug Interactions

The ingredients in Hormone Protect interact with 270 drugs. Click any drug to see the details.

2 of the 2 ingredients in Hormone Protect interact with drugs. Each result below shows which ingredient is responsible. Diindolylmethane TrueBroc

Each ingredient & the kinds of drugs it affects

For each ingredient in Hormone Protect with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions

TrueBroc2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
TrueBroc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hormone Protect, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

Hormone Protect by XYMOGEN: Common Questions

Does Hormone Protect by XYMOGEN interact with any medications?
Yes. Based on its ingredients, Hormone Protect has a known interaction with 270 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hormone Protect contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on hormone replacement therapy?
Not without checking first. Diindolylmethane in this product might increase or decrease estrogen effects and could interfere with HRT. Talk with your doctor or pharmacist before taking it alongside hormone therapy.
What are the most common side effects?
The most common ones are diarrhea, gas, headache, nausea, rash, and vomiting. Broccoli extract may also cause loose stools, abdominal pain, and cramping, especially at higher doses.
Is this safe during pregnancy or while breastfeeding?
Diindolylmethane should be avoided while breastfeeding because there isn't enough safety data. During pregnancy, diindolylmethane is rated likely safe, but because of possible hormone effects, it's best avoided — talk with your doctor for personalized advice. Broccoli extract safety in pregnancy and lactation isn't well established, so check with your healthcare provider.
Why does this product interact with so many medications?
Broccoli contains compounds (glucosinolates) that speed up how your liver processes certain drugs, potentially making them less effective. Diindolylmethane may interfere with estrogens and also affect the same liver pathways, plus it carries risks with water pills. Together, these two ingredients affect a broad range of medications.
Does this actually work for prostate health or cancer?
We don't have enough evidence to rate diindolylmethane for prostate or cancer conditions. Broccoli is possibly effective for colorectal cancer, but evidence is limited for other cancers. If you're considering this for a specific health concern, discuss it with your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hormone Protect is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hormone Protect label
Go deeper

The Full Monographs Behind Hormone Protect’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

Hormone Protect's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team