Huang Qin Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Huang Qin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Huang Qin is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for inflammation, allergies, anxiety and sleep.Based on those ingredients, 946 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Huang Qin Root Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Huang Qin by Herbalist & Alchemist
Ask about any prescription or over-the-counter medication and we check it for interactions with Huang Qin by Herbalist & Alchemist — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Huang Qin by Herbalist & Alchemist
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Huang Qin root extract in dry form, also known as Baikal skullcap. It's a traditional botanical extract used in herbal medicine.
The liquid formulation includes ethyl alcohol and distilled water as inactive ingredients.
Does it work?
Not established
We don't have reliable evidence in our data to rate Baikal skullcap for any of the conditions it's traditionally used for—these include hay fever, anxiety, atherosclerosis, ADHD, prostate cancer, and headache. That doesn't mean it doesn't work; it means human studies are either too small, too few, or not yet done to say whether it works.
How safe is it?
Well-documented data
Taken by mouth, Baikal skullcap is generally well tolerated. The most common side effects reported are abdominal pain, constipation, diarrhea, nausea, vomiting, skin redness, and itching.
Rare serious effects include liver damage and a lung reaction called hypersensitivity pneumonitis (shortness of breath, fever, cough, weight loss). The safety data in humans is limited, and product quality varies.
The safety data advises against use during pregnancy and while breastfeeding.
Meds to double-check
Moderate interaction found
Before taking Huang Qin, check whether you take any blood pressure-lowering drugs, blood thinners (anticoagulants or antiplatelet drugs), diabetes medications, hormones (estrogens), lithium, or thyroid-suppressing drugs—or any medication broken down by your liver's CYP2C19 or CYP1A2 enzymes. Use the medication checker on this page to verify your specific prescriptions.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Huang Qin may be worth considering if you're interested in traditional herbal support, but human safety and effectiveness data are sparse. Before you start, check your medications against our interaction search—especially if you take blood pressure drugs, blood thinners, diabetes medications, lithium, or thyroid drugs.
Talk to your pharmacist or doctor about whether this product fits your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Huang Qin, straight from the product label.
| Brand | Herbalist & Alchemist |
|---|---|
| Barcode (UPC) | 667056108120 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2025 |
| DSLD ID | 340224 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Huang Qin by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Huang Qin Root Extract, Dry | 2.5 mL | -- |
Other ingredients: Ethyl Alcohol, Water, Distilled
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Scutellaria baicalensis
OK (Kosher)
Formulation
Balances immune response
Botanical preparation ratio 1:4
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Certified B Corporation
OK (Kosher)
Suggested/Recommended/Usage/Directions
Suggested use: 30-50 drops (1.5-2.5 mL) in juice or water. Take 4 times per day. Shake well before using.
Precautions
Keep out of children's reach
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Huang Qin by Herbalist & Alchemist label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Huang Qin by Herbalist & Alchemist
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1.5 mL Dosage formLiquid Servings per container24 Amounts shown are per serving.
Huang Qin Root Extract, Dry
Interacts with946 drugs
Baikal skullcap is a traditional Chinese herb (Huang Qin) used for inflammation, allergies, and infections, with active compounds like baicalin and ba...
Huang Qin Root Extract, Dry monograph & interactionsOther (inactive) ingredients: Ethyl Alcohol, Water, Distilled. These complete the product’s ingredient list but are not active constituents.
Huang Qin by Herbalist & Alchemist Drug Interactions
HelloPharmacist Interaction Report
Huang Qin by Herbalist & Alchemist contains Baikal skullcap root extract, which interacts with a number of medications.
The ingredient can theoretically add to the blood-pressure-lowering effects of antihypertensive drugs (drugs that lower blood pressure), raising the risk of blood pressure dropping too low.
Read the full breakdown — every affected drug type, severity by severity
Baikal skullcap may also slow how your liver processes drugs broken down by CYP2C19 and CYP1A2 enzymes, potentially raising their levels in your blood. It can theoretically increase the bleeding risk when taken with blood thinners (anticoagulants) or antiplatelet drugs.
Additionally, it may enhance the blood-sugar-lowering effects of diabetes medications, interfere with hormone replacement therapy (estrogens), reduce how your body clears lithium (a mood-stabilizing medication), and add to the effects of thyroid-suppressing drugs.
Although these interactions are based on animal and laboratory evidence rather than human studies, they're worth checking against your exact medications before you start. Use the search tool on this page to look up any prescriptions you take.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Huang Qin?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Huang Qin interact with 946 drugs. Click any drug to see the details.
1 of the 1 ingredient in Huang Qin interact with drugs. Each result below shows which ingredient is responsible. Huang Qin Root Extract, Dry
AbciximabReoPro
How Abciximab interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Huang Qin Root Extract, Dry + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Huang Qin Root Extract, Dry + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Baikal skullcap with antidiabetes drugs might enhance blood glucose lowering effects.
Read the full Huang Qin Root Extract, Dry + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Huang Qin Root Extract, Dry + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Huang Qin Root Extract, Dry + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Huang Qin — through 1 ingredient. Tap an ingredient for the detail:
Huang Qin Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Huang Qin Root Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Huang Qin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Huang Qin Root Extract, Dry
Anticoagulant/Antiplatelet Drugs
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Preliminary clinical research suggests that taking capsules containing a combination of astragalus, goldthread, and Baikal skullcap daily for 4 weeks inhibits platelet aggregation; the effect seems to be similar to that of aspirin 50 mg daily. It is unclear if this effect is due to Baikal skullcap, other ingredients, or the combination.
Antidiabetes Drugs
Theoretically, concomitant use of Baikal skullcap with antidiabetes drugs might enhance blood glucose lowering effects.
Baicalein, a constituent of Baikal skullcap, has alpha-glucosidase inhibitory activity in vitro. Animal research also suggests that Baikal skullcap enhances the antidiabetic effects of metformin. However, in a small human study, taking Baikal skullcap extract did not enhance the antidiabetic effects of metformin, although it did modestly lower glucose levels during an oral glucose tolerance test (OGTT). Until more is known, use cautiously.
Antihypertensive Drugs
Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Animal research suggests that baicalein, a constituent of Baikal skullcap, might lower blood pressure.
Antithyroid Drugs
Theoretically, concomitant use of Baikal skullcap and antithyroid drugs may result in additive activity and increase the risk of hypothyroidism.
In an animal hyperthyroid model, Baikal skullcap improved levels of triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH). The clinical significance of this effect is unclear.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
In vitro evidence suggests that constituents of Baikal skullcap inhibit the activity of CYP1A2. This effect has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, Baikal skullcap might increase levels of drugs metabolized by CYP2C19 enzymes.
In vitro evidence suggest that wogonin, a constituent of Baikal skullcap, modestly inhibits the activity of CYP2C19 enzymes. This effect has not been reported in humans.
Estrogens
Theoretically, concomitant use of large amounts of Baikal skullcap might interfere with hormone replacement therapy, due to competition for estrogen receptors.
In vitro evidence suggests that Baikal skullcap has estrogenic activity.
Lithium
Theoretically, Baikal skullcap might reduce lithium excretion and increase serum levels of lithium.
Baikal skullcap is thought to have diuretic properties, which may reduce lithium excretion. The dose of lithium might need to be decreased.
Alcohol (Ethanol)
Theoretically, Baikal skullcap might potentiate the sedative effects of alcohol.
In vitro and animal research suggests that Baikal skullcap binds to GABA-A receptors and causes sedation. Theoretically, Baikal skullcap might potentiate the sedative effects of alcohol. Preliminary clinical research has not identified clinically relevant sedation after use of Baikal skullcap; however, a thorough evaluation of safety outcomes has not been conducted.
Cns Depressants
Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
In vitro and animal research suggests that Baikal skullcap binds to GABA-A receptors and causes sedation. Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties. Preliminary clinical research has not identified clinically relevant sedation after use of Baikal skullcap; however, a thorough evaluation of safety outcomes has not been conducted.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, Baikal skullcap might alter the levels and clinical effects of OATP substrates.
Some pharmacokinetic research shows that baicalin, a constituent of Baikal skullcap, can decrease plasma levels of rosuvastatin. The mechanism is thought to involve stimulation of the activity of the organic anion-transporting polypeptide 1B1 (OATP1B1), which transports rosuvastatin into the liver. This decreases plasma levels of the drug, but increases levels at the site of action in the liver. The degree to which rosuvastatin levels are affected depends on the OATP1B1 haplotype of the individual. Baikal skullcap might also affect other OATP1B1 substrates.
P-Glycoprotein Substrates
Theoretically, Baikal skullcap might increase levels of drugs transported by P-glycoprotein.
In vitro and animal research suggests that baicalein, oroxylin A, and wogonin, constituents of Baikal skullcap, can inhibit P-glycoprotein. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Huang Qin, from the product label.
Herbalist & Alchemist
See all Herbalist & Alchemist products- Name
- Herbalist & Alchemist, Inc.
- City
- Washington
- State
- NJ
- ZipCode
- 07882
- Phone Number
- 800-611-8235
- Web Address
- www.herbalist-alchemist.com
Huang Qin by Herbalist & Alchemist: Common Questions
Does Huang Qin by Herbalist & Alchemist interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Huang Qin while I'm pregnant or breastfeeding?
What are the most common side effects?
How many active ingredients does Huang Qin have?
What does Baikal skullcap do?
Is Huang Qin safe to use long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Huang Qin’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Huang Qin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 34 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Baikal Skullcap 34 references
- Huang KC. The pharmacology of Chinese herbs. 2nd ed. New York, NY: CRC Press LLC. 1999;385-6, 400-1.
- Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Planta Med 2000;66:91-3.
- Liao JF, Wang HH, Chen MC, et al. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. Planta Med 1998;64:571-2.
- Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. J Nat Prod 1998;61:1413-5.
- Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
- Fan L, Zhang W, Guo D, et al. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Clin Pharmacol Ther 2007;83:471-6. PubMed
- Chen C, Mireles RJ, Campbell SD, et al. Differential interaction of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos 2005;33:537-46. PubMed
- Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Clin Pharmacol Ther 2007;82:726-33. PubMed
- Konig J, Seithel A, Gradhand U, Fromm MF. Pharmacogenomics of human OATP transporters. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. PubMed
- Chalasani N, Vuppalanchi R, Navarro V, et al. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Ann Intern Med 2012;156:857-60. PubMed
- Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. Ann Intern Med 2012;156:894-5. PubMed
- Huang, W. M., Yan, J., and Xu, J. [Clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(8):465-467.
- Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Pl PubMed
- Lee, Y., Yeo, H., Liu, S. H., Jiang, Z., Savizky, R. M., Austin, D. J., and Cheng, Y. C. Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring. J Med Chem 10-21-2004;47(22):5555-5566. PubMed
- Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. Biological properties of baicalein in cardiovascular system. Curr Drug Targets.Cardiovasc.Haematol.Disord 2005;5(2):177-184. PubMed
- Lee, E., Enomoto, R., Suzuki, C., Ohno, M., Ohashi, T., Miyauchi, A., Tanimoto, E., Maeda, K., Hirano, H., Yokoi, T., and Sugahara, C. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. Ann N Y Acad Sci 2007;1095:521-526. PubMed
- Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Am J Chin Med 2008;36(3):517-540.
- Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. J Nat Prod 2009;72(9):1616-1619. PubMed
- Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. PubMed
- Enomoto, R., Koshiba, C., Suzuki, C., and Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. PubMed
- Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. J Ethnopharmacol. 5- PubMed
- Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. Eur J Drug Metab Pharmacokinet. 6-29-2011; PubMed
- Lin H, Zhou J, Lin K, et al. Efficacy of Scutellaria baicalensis for the treatment of hand, foot, and mouth disease associated with encephalitis in patients infected with EV71: a multicenter, retrospective analysis. Biomed Res Int 2016;2016:5697571.
- Papafragkakis C, Ona MA, Reddy M, Anand S. Acute hepatitis after ingestion of a preparation of Chinese skullcap and black catechu for joint pain. Case Reports Heptal 2016;2016:4356749. PubMed
- Kim M, Lee BC. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. Evid Based Complement Alternat Med. 2019;2019:3239649.
- Braude MR, Bassily R. Drug-induced liver injury secondary to Scutellaria baicalensis (Chinese skullcap). Intern Med J. 2019;49(4):544-546. PubMed
- Shin NR, Gu N, Choi HS, Kim H. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation. Am J Physiol Endocrinol Metab. 2020;318(1):E52-E61.
- Li WJ, Bao J, Zheng DC, et al. Treatments of Peyronie's disease with Scutellaria baicalensis and surgery according to the disease course: a single-center retrospective study of 261 patients. Ann Palliat Med. 2021 Mar;10(3):2979-2989. PubMed
- Adam T, Bursztejn AC, Schmutz JL. Facial eczema from a sunscreen: Scutellaria baicalensis, a novel allergen beginning to attract attention. Contact Dermatitis. 2020 Apr;82(4):253-254.
- Luna-Bastante L, Gatica-Ortega ME, Pastor-Nieto MA, et al. Allergic contact dermatitis to Tinosorb S, Scutellaria baicalensis, and other emerging allergens in cosmetics. Contact Dermatitis. 2020 May;82(5):307-309.
- US Food and Drug Administration (FDA). FDA Alerts Consumers About Potentially Life-Threatening Health Problems Linked to Limbrel. December 19, 2017. Available at: https://www.fda.gov/food/alerts-advisories-safety-information/fda-alerts-consumers-about-pot
- Li L, Gao H, Lou K, et al. Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. Clin Transl Sci 2021;14(5):2017-2024. PubMed
- Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Contact Dermatitis 2022.
- Nogami T, Arai M. Incidence of Herb-induced Liver Injury Caused by Kampo Formulae Containing Scutellariae Radix. Tokai J Exp Clin Med 2022;47(3):94-98.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC