Insinase Ingredients & Drug Interactions
by Metagenics
What is this page for?
First and foremost: checking Insinase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Insinase is a dietary supplement by Metagenics with 3 active ingredients. Its ingredients are commonly taken for digestive and gut health, source of soluble fiber, constipation or bowel regularity.Based on those ingredients, 2,025 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Indian Gum Arabic tree (Acacia nilotica) bark and heartwood extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Insinase by Metagenics
Ask about any prescription or over-the-counter medication and we check it for interactions with Insinase by Metagenics — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Insinase by Metagenics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Insinase contains two active ingredients: Reduced Iso-Alpha Acids and gum arabic (an extract from Indian Gum Arabic tree bark and heartwood). Gum arabic is a water-soluble fiber traditionally used to support digestive and metabolic health, though the evidence for specific conditions remains limited.
The product is made with several inactive ingredients — microcrystalline cellulose, cellulose, stearic acid, croscarmellose sodium, and others — that serve as binders and fillers in the tablet.
Does it work?
Not established
The evidence for gum arabic in this product is not established for the conditions typically studied — metabolic syndrome, kidney function, sickle cell disease, weight management, gum health, and wound healing around ostomy sites. Our data shows insufficient reliable evidence to rate it for any of these uses.
If you're considering Insinase for a specific health goal, talk with your doctor about whether the current evidence supports it for your situation.
How safe is it?
Well-documented data
Gum arabic is generally recognized as safe in food amounts, but supplemental doses — like those in a tablet — haven't been thoroughly studied. The most common side effects are digestive: abdominal bloating, flatulence, nausea, vomiting, cramping, and mild diarrhea.
In one study, these occurred in a significant portion of participants, though they often ease up within two weeks as your body adjusts. Because there's not enough safety data on supplement doses during pregnancy and breastfeeding, you'll want to check with your doctor before using this product if you're pregnant, nursing, or planning to nurse.
Meds to double-check
Moderate interaction found
Before taking Insinase, double-check with your pharmacist or doctor if you take amoxicillin or any other antibiotics or oral medications. Gum arabic can reduce how much of these drugs your body absorbs, especially amoxicillin — you'd need to space them at least 2 hours apart.
We hold no data on the Reduced Iso-Alpha Acids ingredient, so mention that to your pharmacist as well.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Insinase is gum arabic-based and generally well tolerated, but it can interfere with how your body absorbs certain antibiotics and other oral drugs. If you take amoxicillin or any other regular medications, check with your pharmacist or doctor before starting this product — the interaction data spans a large number of individual drugs, and your specific situation matters.
Digestive side effects are common at first but often improve over a couple of weeks.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Insinase, straight from the product label.
| Brand | Metagenics |
|---|---|
| Barcode (UPC) | 755571915399 |
| Net contents | 90 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2023 |
| DSLD ID | 295754 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Insinase by Metagenics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1 Gram(s) | 1% |
| Proprietary Blend | 540 mg | -- |
| Dietary Fiber | 1 Gram(s) | 3% |
| Reduced Iso-Alpha Acids | 0 NP | -- |
| Indian Gum Arabic tree (Acacia nilotica) bark and heartwood extract | 0 NP | -- |
Other ingredients: Microcrystalline Cellulose, Cellulose, Stearic Acid, Croscarmellose Sodium, Sodium Starch Glycolate, Silica, Hypromellose, Medium Chain Triglyceride, Hydroxypropylcellulose, Sodium Copper Chlorophyllin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Insinase is a nutritional supplement with ingredients designed to support healthy insulin function. Developed through ExpresSyn Process, Insinase provides selective kinase response modulators (SKRMs) in the forms of reduced iso-alpha acids (RIAA) and Acacia nilotica. Kinases play an important role in healthy insulin signaling and overall insulin function.
Suggested/Recommended/Usage/Directions
Directions: Take three tablets daily or as directed by your healthcare practitioner.
Formulation
This product is non-GMO, gluten-free, and vegetarian.
This product is non-GMO, gluten-free, and vegetarian.
Non GMO Project Verified nongmoproject.org GFCO.org (Gluten-Free Certification Organization)
Selective kinase response modulators for healthy insulin function
Precautions
Caution: Do not use if pregnant, nursing. If taking medications, consult your healthcare practitioner before use.
Keep out of the reach of children.
Tamper evident: Do not use if safety seal is missing or broken.
Practitioner exclusive
Storage
Storage: Keep tightly closed in a cool, dry place.
Seals/Symbols
Non GMO Project Verified nongmoproject.org GFCO.org (Gluten-Free Certification Organization)
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Insinase by Metagenics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Insinase by Metagenics
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Reduced Iso-Alpha Acids
- › Indian Gum Arabic tree (Acacia nilotica) bark and heartwood extract
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Cellulose, Stearic Acid, Croscarmellose Sodium, Sodium Starch Glycolate, Silica, Hypromellose, Medium Chain Triglyceride, Hydroxypropylcellulose, Sodium Copper Chlorophyllin. These complete the product’s ingredient list but are not active constituents.
Insinase by Metagenics Drug Interactions
HelloPharmacist Interaction Report
Insinase by Metagenics contains gum arabic, which interacts with medications you take by mouth.
The most serious concern is with amoxicillin (Amoxil, Trimox) — gum arabic can noticeably reduce how much of the antibiotic your body actually absorbs, which may lower its effectiveness. A small study showed this effect happens when you take them together.
Read the full breakdown — every affected drug type, severity by severity
Beyond amoxicillin, gum arabic can theoretically alter absorption of other oral drugs because of its fiber content. It may improve how your body takes in certain hard-to-absorb drugs like naproxen, but reduce absorption of water-soluble medications like other antibiotics.
We cannot check the second ingredient, Reduced Iso-Alpha Acids, because we hold no data for it.
Although gum arabic is generally recognized as safe in food, supplemental doses haven't been well studied for drug interactions. To be safe, space gum arabic and amoxicillin apart by at least 2 hours.
For other oral medications, you'll want to check your exact prescriptions with the tool on this page or talk with your pharmacist or doctor before starting.
Altogether, these interactions span 2,023 individual medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Insinase?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Insinase interact with 2,025 drugs. Click any drug to see the details.
2 of the 3 ingredients in Insinase interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Indian Gum Arabic tree (Acacia nilotica) bark and heartwood extract
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Caffeine, Pyrilamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
How Acetaminophen, Chlorzoxazone interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorzoxazone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorzoxazone interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Chlorzoxazone, Codeine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Codeine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Codeine, Doxylamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Codeine, Methocarbamol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Dextromethorphan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Dichloralantipyrine, Isometheptene interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Dichloralphenazone, Isometheptene interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Insinase — through 2 ingredients. Tap an ingredient for the detail:
Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood ExtractOral Drugs Moderate
Interaction Summary
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Indian Gum Arabic Tree (acacia Nilotica) Bark And Heartwood Extract + Acetaminophen, Dichlorophenazone, Isometheptane interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Dichlorophenazone, Isometheptane interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Insinase with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Indian Gum Arabic tree (Acacia nilotica) bark and heartwood extract
Amoxicillin (Amoxil, Trimox)
Gum arabic can reduce the absorption of amoxicillin.
A small study in healthy volunteers shows that taking amoxicillin and gum arabic concurrently significantly reduces the absorption of amoxicillin. Separate doses of amoxicillin from gum arabic by at least 2 hours.
Oral Drugs
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Gum arabic has been used as a suspending osmotic agent in drug formulations. It might improve bioavailability of water-insoluble drugs like naproxen, but reduce absorption of polar drugs like amoxicillin. To avoid changes in absorption, take gum arabic 30-60 minutes after oral medications.
Brand information
Manufacturer and brand details for Insinase, from the product label.
Metagenics
See all Metagenics products- Name
- Metagenics
- City
- Gig Harbor
- State
- WA
- ZipCode
- 98332
- Phone Number
- 800 692 9400
- Web Address
- metagenics.com
Insinase by Metagenics: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Insinase’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Gum Arabic
Interacts with 2,022 drugsGum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplement for digestive health and as a prebiotic. Early s...
Read the full Gum Arabic monograph → Herb & supplement monographBlack Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph →Sources & How We Checked
Insinase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Gum Arabic 8 references
- Jensen CD, Spiller GA, Gates JE, et al. The effect of acacia gum and a water-soluble dietary fiber mixture on blood lipids in humans. J Am Coll Nutr 1993;12:147-54. PubMed
- Eltayeb IB, Awad AI, Elderbi MA, Shadad SA. Effect of gum arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers. J Antimicrob Chemother 2004;54:577-8. PubMed
- Babiker R, Merghani TH, Elmusharaf K, et al. Effects of gum Arabic ingestion on body mass index and body fat percentage in healthy adult females: two-arm randomized, placebo controlled, double-blind trial. Nutr J 2012;11:111. PubMed
- Babiker R, Elmusharaf K, Keogh MB, Banaga AS, Saeed AM. Metabolic effect of gum Arabic (Acacia senegal) in patients with type 2 diabetes mellitus (T2DM): randomized, placebo controlled double blind trial. Functional Foods in Health and Disease. 2017;7(3): DOI
- Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009;14(7):2602-20. PubMed
- Ali NE, Kaddam LA, Alkarib SY, et al. Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial. Int J Nephrol. 2020;2020:7214673.
- Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of acacia gum (E 414) as a food additive. EFSA J. 2017;15(4):e04741. PubMed
- Larson R, Nelson C, Korczak R, et al. Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects. Nutrients 2021;13(2):618. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC