No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

SpectraZyme Pan 9x Ingredients & Drug Interactions

by Metagenics

Tablet Or Pill Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

SpectraZyme Pan 9x is a dietary supplement by Metagenics with 3 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of SpectraZyme Pan 9x by Metagenics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Pancreatin” is listed as a grouped ingredient — the label gives one combined amount (360 mg) without saying how much of each component you get.

SpectraZyme Pan 9x contains 3 active digestive enzymes. Protease breaks down proteins, amylase breaks down carbohydrates, and lipase breaks down fats — together they're meant to help your body digest food more completely.

The inactive ingredients are microcrystalline cellulose (a filler), croscarmellose sodium and silica (for texture), stearic acid (for binding), and a porcine pancreatic concentrate (the enzyme source).

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This product is marketed for general wellness, not a specific health condition, so there's no single claim to grade against clinical evidence.

Why this rating?
  • The label markets general wellness (“support for healthy digestive function”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence for these enzymes isn't well established in the data we hold. For lipase specifically, the data shows insufficient reliable evidence for inflammatory bowel disease, dyspepsia (indigestion), and premature infant conditions — meaning studies haven't yet proven it works for these uses.

We have no effectiveness ratings for protease or amylase on file.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease and lipase are generally well tolerated for most adults, but digestive upset or allergic reactions are possible with protease — especially in people with occupational exposure to airborne enzymes. For pregnancy, the safety data on protease and lipase is too limited; use only if your doctor advises it.

During breastfeeding, check with your healthcare provider first, as data is sparse. Lipase should be used cautiously if you have serious digestive conditions; medical guidance is recommended.

Protease can rarely trigger allergic reactions; this is more common in people exposed to proteases in detergents or occupational settings.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 2 matched ingredients has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could fully check. However, we hold no interaction data for amylase, so if you take any medications, use the checker on this page to confirm your specific drugs are clear.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure marketed for general wellness rather than one specific gradeable purpose. No medication interactions are currently documented, and safety information is well characterized.

This is a basic digestive enzyme blend for people looking to support protein, carbohydrate, and fat digestion. If you have serious digestive disease, take it only under medical supervision.

Pregnant or breastfeeding? Talk to your doctor or pharmacist first.

No major medication interactions are documented, but check your specific drugs before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SpectraZyme Pan 9x, straight from the product label.

Brand Metagenics
Barcode (UPC) 755571939630
Net contents 270 Tablet(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 295863
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SpectraZyme Pan 9x by Metagenics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
270
UPC/BARCODE
755571939630
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Pancreatin360 mg--

Other ingredients: Porcine Pancreatic concentrate, Microcrystalline Cellulose, Croscarmellose Sodium, Silica, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

SpectraZyme Pan 9x is a comprehensive enzyme complex that provides support for healthy digestive function.

The porcine pancreatic concentrate is processed under special conditions so that the delicate enzyme constituents remain intact.

Bioactive pancreatic enzymes for digestive support

Suggested/Recommended/Usage/Directions

Directions: Take one tablet with each meal, or as directed by your healthcare practitioner.

Formulation

This product is non-GMO and gluten-free.

Certified Gluten Free GFCO.org GFCO.org (Gluten-Free Certification Organization)

Precautions

Caution: Do not use if there is a prior history of or a current peptic or duodenal ulcer.

Do not use in individuals who have a known allergy or hypersensitivity to pork protein.

Consult your healthcare practitioner if taking other nutritional supplements or medications.

Keep out of the reach of children.

Seals/Symbols

Certified Gluten Free GFCO.org GFCO.org (Gluten-Free Certification Organization)

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Practitioner Exclusive

See for yourself

SpectraZyme Pan 9x by Metagenics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in SpectraZyme Pan 9x by Metagenics

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container270 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pancreatin

360 mg per serving Form: Porcine

Other (inactive) ingredients: Porcine Pancreatic concentrate, Microcrystalline Cellulose, Croscarmellose Sodium, Silica, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

SpectraZyme Pan 9x by Metagenics Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in SpectraZyme Pan 9x. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for SpectraZyme Pan 9x, from the product label.

Metagenics

See all Metagenics products
Name
Metagenics
City
Gig Harbor
State
WA
ZipCode
98332
Phone Number
800 692 9400
Web Address
metagenics.com
Pharmacist Counseling Corner

SpectraZyme Pan 9x by Metagenics: Common Questions

Does SpectraZyme Pan 9x by Metagenics interact with any medications?
We do not currently list a known interaction for the mapped ingredients in SpectraZyme Pan 9x. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
SpectraZyme Pan 9x contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does each enzyme in this product do?
Amylase breaks down carbohydrates, protease breaks down proteins, and lipase breaks down fats. Together they're designed to help your digestive system work through a full meal.
Is protease safe if I'm pregnant?
Safety hasn't been established during pregnancy, so it's best avoided unless your doctor prescribes it. Talk to your doctor or pharmacist about whether this product is right for you.
Can I take this while breastfeeding?
There's little safety data on protease and lipase during breastfeeding. Check with your healthcare provider first before use.
Does this work for indigestion or digestive conditions?
For lipase specifically, we don't yet have reliable evidence it works for indigestion or inflammatory bowel disease. If you have serious digestive conditions, talk to your doctor before taking it.
What are the most common side effects?
Digestive upset is possible with protease. Lipase has rarely been linked to serious gastrointestinal effects in premature infants, but no adverse effects have been reported in adults using the supplement form — though a complete safety review hasn't been done.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SpectraZyme Pan 9x is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SpectraZyme Pan 9x label
Sources

Sources & How We Checked

SpectraZyme Pan 9x's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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