Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Acid Ease Ingredients & Drug Interactions

by Nature's Way

Acid Ease label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Acid Ease against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Acid Ease is a dietary supplement by Nature's Way with 6 active ingredients. Its ingredients are commonly taken for sore throat and cough, heartburn and acid reflux, digestive upset and ibs.Based on those ingredients, 2,040 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Marshmallow Root Extract, Slippery Elm. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Acid Ease by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Acid Ease by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Acid Ease by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 6 active ingredients.
  • “Active Enzymes” is listed as a grouped ingredient — the label gives one combined amount (182 mg) without saying how much of each component you get.

Acid Ease contains 6 active ingredients, each a digestive enzyme or plant extract meant to support your digestion. The enzymes—amylase, lipase, and cellulase—break down different food components: carbohydrates, fats, and fiber, respectively.

Slippery elm and marshmallow root are soothing botanicals that coat the digestive tract, while gamma-oryzanol is a compound from rice bran. The product also contains inactive ingredients (hypromellose, cellulose, and ascorbyl palmitate) that make up the capsule and help keep the formula stable.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Digestive support for sensitive stomachs.
  • We looked for evidence on: Dyspepsia, Irritable bowel syndrome (IBS), Constipation, Diarrhea, Inflammatory bowel disease (IBD), Peptic ulcers — and 4 related terms.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD) (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Marshmallow is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diarrhea.

The evidence for most of these ingredients is still being worked out. Lipase, slippery elm, and marshmallow root all have insufficient reliable evidence to confirm they work for digestive complaints like dyspepsia (indigestion) or inflammatory bowel disease in supplement form.

Gamma-oryzanol is possibly effective for high cholesterol (dyslipidemia), but we don't have solid proof that it helps with digestion or the other conditions this product may be marketed for. In short, you're not getting a strong evidence-based promise here—the ingredients are used traditionally, but clinical proof is limited.

The evidence, ingredient by ingredient Slippery Elm Marshmallow Gamma-oryzanol Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lipase, slippery elm, and marshmallow root are generally well tolerated for short-term use, though high-quality long-term safety data are sparse. Adverse effects are rare; slippery elm pollen can trigger allergies in sensitive people, and the bark itself may cause contact dermatitis or hives on skin contact.

Lipase carries one rare but serious caution: when used in premature infants, a recombinant form has caused gastrointestinal problems including abdominal pain, bloating, and in rare cases a serious infection of the bowel (necrotizing enterocolitis)—but this product is not intended for infants. Gamma-oryzanol is well tolerated in studies, though long-term safety isn't well established.

For pregnancy, lipase has too little data—check with your doctor before using it. Marshmallow root and gamma-oryzanol are best avoided during pregnancy due to insufficient safety information.

For breastfeeding, all three have limited or no data; talk with your healthcare provider before using this product if you're nursing.

Side effects, ingredient by ingredient Slippery Elm Marshmallow Gamma-oryzanol Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Marshmallow, Slippery Elm.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 2,041 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check any oral medication (tablets, capsules, liquids) you take—slippery elm may reduce absorption. If you take lithium, alert your pharmacist; marshmallow could raise its level and cause toxicity.

Blood thinners (anticoagulants or antiplatelet drugs) are a Minor flag as well, depending on which one you're on. We couldn't check amylase and cellulase, so if you have questions about those, ask us directly.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking for digestive support and have no medications that interact with slippery elm or marshmallow, this product is worth discussing with your pharmacist—just know the evidence for how well it works is still weak. If you take any oral medications, lithium, or blood thinners, check your exact drugs against our interaction tool first.

Pregnant or breastfeeding? Talk to your doctor or pharmacist before starting; the safety data aren't there to give a clear thumbs-up.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Acid Ease, straight from the product label.

Brand Nature's Way
Barcode (UPC) 750856606900
Net contents 90 Vegan Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 259262
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Acid Ease by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
750856606900
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Amylase0 NP--
Lipase0 NP--
Cellulase0 NP--
Slippery Elm200 mg--
Marshmallow Root Extract200 mg--
Gamma-Oryzanol150 mg--
Active Enzymes182 mg--

Other ingredients: Hypromellose, Cellulose, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Digestive support for sensitive stomachs

Digestion formula Digestive support for sensitive stomachs

Contains no sugar, salt, yeast, dairy products, or artificial colors, or flavors.

Vegan

Formula

Acid Ease is specially formulated for sensitive stomachs. A unique blend of active enzymes with marshmallow and slippery elm bark creates a perfect combination for digestive support. Active enzymes (per serving) Assay Method - Activity Amylase - FCC (pH 4.8) 11,900 DU Lipase - FCC (pH 6.5) - 67 FIP Cellulase - FCC (pH 4.5) - 19 CU

Brand IP Statement(s)

Nature's Way Since 1969

Copyright 2019 Nature's Way Brands, LLC

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 2 capsules 3 times daily at the beginning of meals. Acid Ease may also be taken as needed between meals.

Precautions

Warning: This product contains Slippery Elm. Slippery Elm should not be taken together with any medication as it may interfere with absorption. If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with printed inner seal. Do not use if seal is broken or missing.

General Statements

Bottles made from 97% post-consumer recycled plastic

Seals/Symbols

Quality Global Sourcing - Bottled & Tested in the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Acid Ease by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Acid Ease label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Acid Ease by Nature's Way

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Slippery Elm

Interacts with
2,022 drugs
200 mg per serving

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated di...

Slippery Elm monograph & interactions

Marshmallow Root Extract

Interacts with
2,040 drugs
200 mg per serving

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats,...

Marshmallow Root Extract monograph & interactions

Gamma-Oryzanol

No known
interactions
150 mg per serving Form: Rice Bran

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The...

Gamma-Oryzanol monograph & interactions

Active Enzymes

182 mg per serving
  • › Amylase
  • › Lipase
  • › Cellulase

Other (inactive) ingredients: Hypromellose, Cellulose, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Acid Ease by Nature's Way Drug Interactions

Want to check YOUR meds against Acid Ease?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,040Drugs
2,022 Moderate 18 Minor

Ingredients driving the most interactions

Marshmallow Root Extract 2,040
Slippery Elm 2,022

Individual Drug Interactions

The ingredients in Acid Ease interact with 2,040 drugs. Click any drug to see the details.

2 of the 6 ingredients in Acid Ease interact with drugs. Each result below shows which ingredient is responsible. Marshmallow Root Extract Slippery Elm

Each ingredient & the kinds of drugs it affects

For each ingredient in Acid Ease with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Marshmallow Root Extract3 drug types · 2,040 drugs

Lithium

Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Marshmallow Root Extract full monograph & interactions

Slippery Elm1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Acid Ease, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Acid Ease by Nature's Way: Common Questions

Does Acid Ease by Nature's Way interact with any medications?
Yes. Based on its ingredients, Acid Ease has a known interaction with 2,040 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Acid Ease contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Acid Ease actually help with indigestion?
The ingredients—lipase, slippery elm, and marshmallow—are traditional remedies for digestive upset, but we don't have strong clinical proof that they work for indigestion in supplement form. The evidence is rated as insufficient. Some people report relief, but it's not backed by solid trials yet.
Can I take Acid Ease while I'm pregnant?
Not without checking with your doctor first. Marshmallow root and gamma-oryzanol should be avoided in pregnancy because there isn't enough safety data. Lipase also has too little information. Your doctor or pharmacist can give you personalized advice based on your situation.
Is it safe to take while breastfeeding?
There isn't enough reliable safety data on any of these ingredients during breastfeeding, so talk with your healthcare provider before using this product. They can weigh the benefits and risks for your situation.
What's gamma-oryzanol in here for?
Gamma-oryzanol is a compound from rice bran that is possibly effective for high cholesterol. In this digestive blend, it's included as a supporting ingredient, though the main focus is the enzymes and soothing herbs.
Do I need to space this out from my other medications?
Yes, if you take other medications by mouth. Slippery elm and marshmallow both can slow drug absorption, so take them 30 to 60 minutes after your medications to avoid interference. Run your exact drugs through our interaction checker to be sure.
Can this cause allergies?
Slippery elm pollen is a known allergen and can trigger reactions in sensitive people. Contact with the bark itself may also cause a rash or hives. If you have a tree pollen allergy or sensitive skin, let your pharmacist know before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Acid Ease is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Acid Ease label
Go deeper

The Full Monographs Behind Acid Ease’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph → Herb & supplement monograph

Marshmallow

Interacts with 2,040 drugs

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...

Read the full Marshmallow monograph → Herb & supplement monograph

Gamma-oryzanol

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes fro...

Read the full Gamma-oryzanol monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

Acid Ease's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Slippery Elm 3 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed

See these in context on the Slippery Elm monograph →

Marshmallow 5 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Hage-Sleiman R, Mroueh M, Daher CF. Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon. Pharm Biol 2011;49(3):327-33.

See these in context on the Marshmallow monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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