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Dietary supplement

Petadolex Pro-Active Ingredients & Drug Interactions

by Nature's Way

Petadolex Pro-Active label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Petadolex Pro-Active against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Petadolex Pro-Active is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, hay fever (allergic rhinitis), asthma symptoms.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Purple Butterbur Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Petadolex Pro-Active by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Petadolex Pro-Active by Nature's Way — and tell you which ingredient is responsible.

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Computed from our clinical databases

HelloPharmacist Scorecard of Petadolex Pro-Active by Nature's Way

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

None of the active ingredients could be matched to our evidence database, so the stated purpose can't be graded.

Why this rating?
  • The label markets this product for: supports healthy brain blood vessel relaxation.
  • We looked for evidence on: Migraine headache, Cerebral blood flow, Vascular tone, Headache prevention.
  • We couldn't match any of the active ingredients to a HelloPharmacist monograph, so there's no evidence data to grade that purpose against.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Purple Butterbur Root Extract” is listed as a grouped ingredient — the label gives one combined amount (50 mg) without saying how much of each component you get.
Known Interaction Concern
Not assessable

None of the active ingredients could be matched to our interaction database.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was nothing to check interactions against.
Safety Information
Unable to assess

None of the active ingredients could be matched to our safety data.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was no safety data to measure.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Medication interactions could not be assessed, and safety information could not be assessed.

Assessment coverage: 0 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Petadolex Pro-Active, straight from the product label.

Brand Nature's Way
Barcode (UPC) 763948048069
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 328016
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Petadolex Pro-Active by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
763948048069
IngredientAmount% DV
Purple Butterbur Root Extract50 mg--
Petasins7.5 mg--

Other ingredients: Medium Chain Triglyceride, Gelatin, Glycerin, Sorbitol, Water, Purified, Riboflavin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports healthy brain blood vessel relaxation Made with the quality you trust

Bottled and tested in the USA Product of Germany

Supports healthy brain blood vessel relaxation

Gluten free. No salt, wheat, soy, or dairy.

Formula

With patented Petadolex butterbur root extract Butterbur extract with petasin and isopetasin, compounds that support healthy blood vessel tone

50 mg Petadolex per serving

General Statements

Explore more products at naturesway.com

Bottle made from 50% post-consumer recycled plastic

Brand IP Statement(s)

Petadolex Pro-Active is distributed by Nature's Way under license from Weber & Weber. Copyright 2024 Nature's Way Brands, LLC

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Recommendation: Adults swallow 1 softgel three times daily.

Precautions

Do not bite or chew. Discontinue use and consult a healthcare professional if you develop symptoms of liver trouble, such as abdominal pain, dark urine, or jaundice.

Warning: Do not use if you are pregnant, nursing, or have a liver disorder. If you are taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Petadolex Pro-Active by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Petadolex Pro-Active label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Petadolex Pro-Active by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Purple Butterbur Root Extract

Interacts with
87 drugs
50 mg per serving

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...

Purple Butterbur Root Extract monograph & interactions
  • › Petasins

Other (inactive) ingredients: Medium Chain Triglyceride, Gelatin, Glycerin, Sorbitol, Water, Purified, Riboflavin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Petadolex Pro-Active by Nature's Way Drug Interactions

Petadolex Pro-Active contains a single active ingredient, and it has known interactions with 87 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Petadolex Pro-Active?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Purple Butterbur Root Extract 87

Individual Drug Interactions

The ingredients in Petadolex Pro-Active interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Petadolex Pro-Active interact with drugs. Each result below shows which ingredient is responsible. Purple Butterbur Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Petadolex Pro-Active with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Purple Butterbur Root Extract1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D
Purple Butterbur Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Petadolex Pro-Active, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Petadolex Pro-Active by Nature's Way: Common Questions

Does Petadolex Pro-Active by Nature's Way interact with any medications?
Yes. Based on its ingredients, Petadolex Pro-Active has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Petadolex Pro-Active contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Petadolex Pro-Active is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Petadolex Pro-Active label
Go deeper

The Full Monographs Behind Petadolex Pro-Active’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butterbur

Interacts with 87 drugs

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However, raw or unprocessed butterbur contains...

Read the full Butterbur monograph →
Sources

Sources & How We Checked

Petadolex Pro-Active's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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