Gluten Defense Ingredients & Drug Interactions
by Nature's Way
What is this page for?
First and foremost: checking Gluten Defense against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Gluten Defense is a dietary supplement by Nature's Way with 7 active ingredients. Its ingredients are commonly taken for improving mineral absorption, breaking down phytic acid (phytate) in grains and legumes, supporting digestion of plant-based foods.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Gluten Defense by Nature's Way
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Gluten Defense contains seven active ingredients: three digestive enzymes — Amylase, Sucrase, and Lactase — plus Phytase, Lipase, Cellulase, and a DPP IV Protease Blend. These are all enzymes designed to help break down different components of food during digestion.
The product also contains several inactive ingredients (fillers and capsule material): Hypromellose, Cellulose, Inulin, Calcium Laurate, and Silica.
Does it work?
Strong evidence
The evidence on most of these enzymes is limited. Lactase — which helps break down the milk sugar lactose — is rated Effective for lactose intolerance, so that's the one ingredient here backed by solid data.
For the others (Phytase, Lipase, and the remaining enzymes), there isn't enough reliable evidence yet to say whether they work for the conditions they're marketed toward. We hold no effectiveness ratings for Amylase, Sucrase, Cellulase, or DPP IV Protease Blend in our data.
How safe is it?
Well-documented data
Lactase is generally well tolerated when used as directed. Lipase is also generally well tolerated, though people with serious digestive conditions should use it only under medical supervision.
Phytase has limited safety data; while it's generally considered low-risk in foods, supplement safety information is scarce. One important note: occupational exposure to airborne powdered phytase in industrial settings has caused allergic reactions and airway inflammation in some workers — though that's different from taking it in a capsule.
We couldn't check safety data for Amylase, Sucrase, Cellulase, or DPP IV Protease Blend.
Meds to double-check
No known interactions
No interactions are documented for the ingredients we could check. Still, use the medication checker on this page to look up your specific drugs before you start.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
This is an enzyme blend aimed at supporting digestion, with Lactase being the only ingredient backed by solid evidence (for lactose intolerance). If you have a serious digestive condition, check with your doctor first — especially before using Lipase.
Talk to your pharmacist about whether this product fits your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Gluten Defense, straight from the product label.
| Brand | Nature's Way |
|---|---|
| Barcode (UPC) | 763948039524 |
| Net contents | 120 Vegan Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 24, 2025 |
| DSLD ID | 327974 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Gluten Defense by Nature's Way, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Lipase | 0 NP | -- |
| Sucrase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Microbial Enzymes | 621 mg | -- |
| DPP IV Protease Blend | 0 NP | -- |
Other ingredients: Hypromellose, Cellulose, Inulin, Calcium Laurate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Helps digest wheat and dairy Gluten from grains and casein from dairy. Gluten & casein digestive enzymes
Bottled and tested in the USA
Vegan V Gelatin Free
Vegan V Gelatin Free
Contains no dairy, gelatin, or artificial colors or flavors.
Precautions
Caution: If you are pregnant, nursing, have diabetes, or if you are taking any medications, consult a healthcare professional before use.
While gluten defense with reduce the level of reactive gliadin and gluten proteins in a meal, it is advised that celiac disease sufferers continue with their normal gluten-exclusion diet as even small amounts of gliadin can cause adverse reactions in the most sensitive individuals.
Keep out of reach of children.
Safety sealed with inner seal. Do not use if seal is broken or missing.
Storage
Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.
Brand IP Statement(s)
Copyright 2024
Seals/Symbols
Vegan V Gelatin Free
General Statements
Questions? 1-800-962-8873 / naturesway.com Bottle made from 50% post-consumer recycled plastic
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formula
Digestive enzymes Targeted digestive enzymes
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommendation: Adults take 2 capsules with each meal or as recommended by a healthcare professional.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Gluten Defense by Nature's Way label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Gluten Defense by Nature's Way
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Hypromellose, Cellulose, Inulin, Calcium Laurate, Silica. These complete the product’s ingredient list but are not active constituents.
Gluten Defense by Nature's Way Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Gluten Defense. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Gluten Defense, from the product label.
Nature's Way
See all Nature's Way products- Name
- Nature's Way Brands, LLC
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- 1-800-962-8873
- Web Address
- naturesway.com
Gluten Defense by Nature's Way: Common Questions
Does Gluten Defense by Nature's Way interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this product actually work?
Is this safe to take if I have a sensitive stomach or digestive condition?
Can I take this while pregnant or breastfeeding?
What does each enzyme do in this product?
Will this help me digest gluten?
Are there any fillers or other ingredients I should know about?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Gluten Defense is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Gluten Defense’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Phytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
Gluten Defense's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 9 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC