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Dietary supplement

Ionic Iodine 500 PPM Ingredients & Drug Interactions

by Good State

Ionic Iodine 500 PPM label
See full label image
Liquid Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ionic Iodine 500 PPM against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ionic Iodine 500 PPM is a dietary supplement by Good State with 1 active ingredient. Its ingredients are commonly taken for preventing iodine deficiency, supporting thyroid hormone production, general energy and metabolism support.Based on those ingredients, 7 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Iodine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ionic Iodine 500 PPM by Good State

Ask about any prescription or over-the-counter medication and we check it for interactions with Ionic Iodine 500 PPM by Good State — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ionic Iodine 500 PPM by Good State

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: iodine in liquid ionic form at 500 parts per million. The remaining ingredients—reverse osmosis water, fulvic acid, sorbic acid, and ionic iodine (also listed separately)—are inactive components that support delivery and stability of the supplement.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support for healthy thyroid function.
  • We looked for evidence on: Iodine deficiency, Thyroid cancer, Hyperthyroidism, Thyroid storm, Radiation exposure, Thyroid hormones — and 1 related terms.
  • The strongest evidence on file: Iodine is rated "Likely Effective" for Radiation exposure (Natural Medicines).
  • Also on file: Iodine is rated "Likely Effective" for Iodine deficiency.
  • Also on file: Iodine is rated "Possibly Effective" for Thyroid storm.

Iodine is likely effective for preventing thyroid problems after radiation exposure and for correcting iodine deficiency. It's possibly effective for oral mucositis (mouth sores) and periodontitis (gum disease), though the evidence for these uses is more limited.

The evidence, ingredient by ingredient Iodine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Iodine at normal dietary amounts is well tolerated, but high doses can trigger thyroid problems including overactive thyroid (hyperthyroidism) or underactive thyroid (hypothyroidism). The most common side effects are abdominal upset, diarrhea, nausea, metallic taste, and headache.

Rarely, iodine can cause allergic reactions ranging from rash to anaphylaxis; if you have a history of iodine hypersensitivity, steer clear. Chronic or very high intake may cause acneform skin lesions (iododerma).

In pregnancy, iodine is necessary for your baby's development, but use only the amount your doctor recommends and avoid high-dose products. During breastfeeding, some iodine passes into breast milk; follow your doctor's guidance to avoid excess.

There isn't enough data on file to know whether this specific product is safe in pregnancy or lactation beyond those general cautions, so talk with your doctor or pharmacist for advice tailored to your situation.

Side effects, ingredient by ingredient Iodine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Iodine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 7 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you're on lithium (risk of worsened underactive thyroid), antithyroid drugs (iodine may alter their effects), or amiodarone (risk of excessive iodine levels). All three require thyroid function monitoring if combined with iodine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ionic iodine is a straightforward supplement for preventing or correcting iodine deficiency and for protection after radiation exposure. If you take lithium, antithyroid medications, or amiodarone, you'll need to discuss this supplement with your doctor or pharmacist before starting—the interaction risks are real.

Anyone with a history of iodine sensitivity should avoid it. For everyone else, stick to normal dietary amounts and check in with your own healthcare provider about whether this dose is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ionic Iodine 500 PPM, straight from the product label.

Brand Good State
Barcode (UPC) 857515003848
Net contents 4 fl. Oz.; 120 mL
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 276943
Product type Mineral
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ionic Iodine 500 PPM by Good State, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Drop(s)
Maximum serving Sizes:
4 Drop(s)
Servings per container
600
UPC/BARCODE
857515003848
IngredientAmount% DV
Iodine500 mg333%

Other ingredients: reverse osmosis Water, Fulvic Acid, Sorbic Acid, Ionic Iodine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Good State's ionic minerals are knows for their high bioavailability, while other supplements can be extremely low.

Contains no sugars , soy, GMO, dairy, gluten, starch, artificial flavors, colors, or animal by-products, and is hypoallergenic.

Suitable for vegans.

Good State is proud to follow Good Manufacturing Practices (GMP)

Ultra concentrate

Higher bioavailability

Formula

Note: Iodine may be beneficial for a healthy thyroid

General Statements

No product claims are being made or implied. Research is ongoing.

100% satisfaction guaranteed

X000KOZAZ7 FBA USA

Professional grade

Text support +1-215-608-1124

Seals/Symbols

Made in USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Give your body what it needs! Good State Health Solutions

Good State's nano ionic supplements

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults: Take 1-4 drops daily in water or juice. 1 drop provides 3/4 of the RDA. 1 mL proves 2.5mg. Use more if needed or recommended by your health care professional. Shake well before using. Do not take on an empty stomach. Must be diluted. Do not take without water or juice.

Precautions

Do not take on an empty stomach. Must be diluted. Do not take without water or juice.

Caution: Keep out of reach of children.

Always speak with your physician before using any dietary supplement. Do not use if tamper-evident seal is broken or missing.

Storage

For freshness after opening, store in a cool, dark place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ionic Iodine 500 PPM by Good State label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ionic Iodine 500 PPM label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ionic Iodine 500 PPM by Good State

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Drop(s) Dosage formLiquid Servings per container600 Amounts shown are per serving.

Iodine

Interacts with
7 drugs
500 mg per serving

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements...

Iodine monograph & interactions

Other (inactive) ingredients: Reverse osmosis Water, Fulvic Acid, Sorbic Acid, Ionic Iodine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ionic Iodine 500 PPM by Good State Drug Interactions

Want to check YOUR meds against Ionic Iodine 500 PPM?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
7Drugs
7 Moderate

Ingredients driving the most interactions

Iodine 7

Individual Drug Interactions

The ingredients in Ionic Iodine 500 PPM interact with 7 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ionic Iodine 500 PPM interact with drugs. Each result below shows which ingredient is responsible. Iodine

Each ingredient & the kinds of drugs it affects

For each ingredient in Ionic Iodine 500 PPM with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Iodine3 drug types · 7 drugs

Amiodarone (Cordarone)

Combining iodine with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with iodine might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.

Likelihood Probable Evidence D
Antithyroid Drugs

Iodine might alter the effects of antithyroid drugs.
Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking iodine while using antithyroid drugs could alter the effects of the antithyroid drugs.

Likelihood Probable Evidence D
Lithium

Combining iodine with lithium might have additive hypothyroid effects.
Lithium can inhibit thyroid function. Several case reports suggest that concomitant use of lithium and potassium iodide can reduce thyroid function in otherwise healthy adults. Monitor thyroid function.

Likelihood Probable Evidence D
Iodine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ionic Iodine 500 PPM, from the product label.

Good State

Name
GoodState, Inc.
Street Address
575 Virginia Drive, Suite C
City
Fort Washington
State
PA
ZipCode
19034
Phone Number
1-866-227-6097
Web Address
www.GoodState.com
Pharmacist Counseling Corner

Ionic Iodine 500 PPM by Good State: Common Questions

Does Ionic Iodine 500 PPM by Good State interact with any medications?
Yes. Based on its ingredients, Ionic Iodine 500 PPM has a known interaction with 7 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ionic Iodine 500 PPM contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is iodine safe to take during pregnancy?
Iodine is necessary during pregnancy, but use only the amount your doctor advises and avoid high-dose products. There isn't enough data on this specific supplement to know whether it's safe in pregnancy beyond that general guidance, so talk with your doctor or pharmacist for personalized advice.
What are the most common side effects?
The most common side effects are abdominal upset, diarrhea, nausea, metallic taste, and headache. These are generally mild when iodine is taken in normal amounts.
Can I take this if I have a shellfish allergy?
Most people labeled with "iodine allergy" are actually reacting to shellfish proteins or other agents, not iodine itself. If you have a true history of iodine hypersensitivity (rash, swelling, or severe reactions specifically to iodine products), avoid this supplement. If you're unsure, talk with your doctor or pharmacist.
What is this supplement used for?
Iodine is likely effective for preventing thyroid problems after radiation exposure and for correcting iodine deficiency. It's possibly effective for mouth sores and gum disease, though evidence for those uses is more limited.
How much iodine is in this product compared to my daily need?
The facts don't specify the serving size or how much iodine per serving this 500 PPM liquid contains, so I can't compare it to your daily requirement. Check the label or ask your doctor or pharmacist whether this dose is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ionic Iodine 500 PPM is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ionic Iodine 500 PPM label
Go deeper

The Full Monographs Behind Ionic Iodine 500 PPM’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Iodine

Interacts with 7 drugs

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements help when you are truly deficient, but...

Read the full Iodine monograph →
Sources

Sources & How We Checked

Ionic Iodine 500 PPM's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Iodine 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Goodman GA, Rall TW, Nies AS, Taylor P. The Pharmacological Basis of Therapeutics, 9th ed.
  3. Ghent WR, Eskin BA, Low DA, Hill LP. Iodine replacement in fibrocystic disease of the breast. Can J Surg 1993;36:453-60.
  4. Potassium iodide for nuclear exposure. Pharmacist's Letter/Prescriber's Letter 2001;17(12):171214.
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  6. Cabezas C, Bustamante B, Holgado W, Begue RE. Treatment of cutaneous sporotrichosis with one daily dose of potassium iodide. Pediatr Infect Dis J 1996;15:352-4. PubMed
  7. Sterling JB, Heymann WR. Potassium iodide in dermatology: a 19th century drug for the 21st century-uses, pharmacology, adverse effects, and contraindications. J Am Acad Dermatol 2000;43:691-7. PubMed
  8. Yarrington CD, Pearce EN. Dietary iodine in pregnancy and postpartum. Clin Obstet Gynecol 2011;54:459-70. PubMed
  9. Goel, S., Mandhani, A., Srivastava, A., Kapoor, R., Gogoi, S., Kumar, A., and Bhandari, M. Is povidone iodine an alternative to silver nitrate for renal pelvic instillation sclerotherapy in chyluria? BJU.Int 2004;94(7):1082-1085. PubMed
  10. Teng, W., Shan, Z., Teng, X., Guan, H., Li, Y., Teng, D., Jin, Y., Yu, X., Fan, C., Chong, W., Yang, F., Dai, H., Yu, Y., Li, J., Chen, Y., Zhao, D., Shi, X., Hu, F., Mao, J., Gu, X., Yang, R., Tong, Y., Wang, W., Gao, T., and Li, C. Effect of iodine int
  11. Crawford, B. A., Cowell, C. T., Emder, P. J., Learoyd, D. L., Chua, E. L., Sinn, J., and Jack, M. M. Iodine toxicity from soy milk and seaweed ingestion is associated with serious thyroid dysfunction. Med J Aust. 10-4-2010;193(7):413-415. PubMed
  12. Ohkuma, M. Molluscum contagiosum treated with iodine solution and salicylic acid plaster. Int J Dermatol. 1990;29(6):443-445. PubMed
  13. Connelly KJ, Boston BA, Pearce EN, Sesser D, Snyder D, Braverman LE, Pino S, LaFranchi SH. Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion. J Pediatr. 2012 Oct;161(4):760-2. PubMed
  14. Kasahara T, Narumi S, Okasora K, Takaya R, Tamai H, Hasegawa T. Delayed onset congenital hypothyroidism in a patient with DUOX2 mutations and maternal iodine excess. Am J Med Genet A. 2013 Jan;161A(1):214-7.
  15. Murcia M, Rebagliato M, Iñiguez C, Lopez-Espinosa MJ, Estarlich M, Plaza B, Barona-Vilar C, Espada M, Vioque J, Ballester F. Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 year of age. Am J Epidemiol. 2011 Apr 1;173(7):8 PubMed
  16. Sang Z, Wang PP, Yao Z, Shen J, Halfyard B, Tan L, Zhao N, Wu Y, Gao S, Tan J, Liu J, Chen Z, Zhang W. Exploration of the safe upper level of iodine intake in euthyroid Chinese adults: a randomized double-blind trial. Am J Clin Nutr. 2012 Feb;95(2):367-73 PubMed
  17. Speeckaert MM, Speeckaert R, Wierckx K, Delanghe JR, Kaufman JM. Value and pitfalls in iodine fortification and supplementation in the 21st century. Br J Nutr. 2011 Oct;106(7):964-73. PubMed
  18. Yun SE, Kang Y, Bae EJ, Hwang K, Jang HN, Cho HS, Chang SH, Park DJ. Iodine-induced thyrotoxic hypokalemic paralysis after ingestion of Salicornia herbace. Ren Fail. 2014 Apr;36(3):461-3.
  19. Iodine Hypersensitivity. Pharmacist's Letter/Prescriber's Letter 2011; 27(5):270504.
  20. Hammel JA, Selby JC. Pustular eruption in a patient with cancer treated with complementary and alternative medicine. JAMA Dermatology 2017 October; E1. doi: 10.1001/jamadermatol.2017.3749. [Epub ahead of print] PubMed
  21. Gil GS, Smith BW, Guerra JR, Williams WT. Acute Delirium in a Hypothyroid Patient Precipitated by Iodine Supplements Use. Am J Ther. 2018;25(6):e717-e718. PubMed
  22. Hamby T, Kunnel N, Dallas JS, Wilson DP. Maternal iodine excess: an uncommon cause of acquired neonatal hypothyroidism. J Pediatr Endocrinol Metab. 2018;31(9):1061-1064. PubMed
  23. Censi S, Watutantrige-Fernando S, Groccia G, et al. The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine
  24. Rovner MS, Wolf BJ, Rubin M, et al. Instillation of 5% Povidone-Iodine Ophthalmic Drops Decreases the Respiratory Rate in Children Undergoing Strabismus Surgery: A Randomized Controlled Trial. J Pediatr Ophthalmol Strabismus. 2019;56(6):378-382. PubMed
  25. Guenezan J, Garcia M, Strasters D, et al. Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2021;147(4):400-401. PubMed
  26. Li F, Wan S, Zhang L, et al. A Meta-Analysis of the Effect of Iodine Excess on the Intellectual Development of Children in Areas with High Iodine Levels in their Drinking Water. Biol Trace Elem Res 2022;200(4):1580-1590. PubMed

See these in context on the Iodine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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