Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Joint-Ease Ingredients & Drug Interactions

by Akasha Naturals

Joint-Ease label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Joint-Ease against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Joint-Ease is a dietary supplement by Akasha Naturals with 3 active ingredients. Its ingredients are commonly taken for memory and concentration, digestive upset, hair growth.Based on those ingredients, 372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rosemary Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Joint-Ease by Akasha Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Joint-Ease by Akasha Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Joint-Ease by Akasha Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “A Proprietary Blend of” is a proprietary blend — the label gives one combined amount (350 mg) without saying how much of each component you get.

Joint-Ease contains 3 active ingredients. The main one is rosemary leaf extract, a concentrated form of the culinary herb.

The product also includes Tetrase and Oleanolic Acid, though we have no data on hand for those two. The capsule itself is made from gelatin, olive oil, glycerin, yellow beeswax, water, and a green food colorant (sodium copper chlorophyllin).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Rosemary's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: joint comfort and support.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), Fibromyalgia, Joint pain, Inflammatory joint conditions, Musculoskeletal discomfort.
  • The closest evidence on file: Rosemary is rated "Insufficient Reliable Evidence To Rate" for Fibromyalgia (Natural Medicines).
  • Also on file: Rosemary is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis, Rheumatoid arthritis (RA).

The evidence on rosemary for joint health isn't on file in the data we hold. Rosemary leaf extract does show possibly effective evidence for memory, but the other potential uses listed—including age-related thinking changes and hair loss—don't have enough reliable evidence for us to rate.

We have no effectiveness data for Tetrase or Oleanolic Acid.

The evidence, ingredient by ingredient Rosemary

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rosemary is well tolerated in the small amounts you'd get from cooking with it. At higher medicinal doses, caution applies: the safety data suggests avoiding large doses during pregnancy, and there isn't enough data on medicinal-strength doses while breastfeeding to know either way—talk with your pharmacist or doctor about that if it applies to you.

Side effects from rosemary are rare but can include allergic reactions on the skin (contact dermatitis) or swelling of the lips and gums if used in the mouth. In very sensitive people, topical use might trigger sun sensitivity.

The undiluted oil and one of its components (camphor) could theoretically cause seizures, though this is uncommon.

Side effects, ingredient by ingredient Rosemary

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rosemary.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 372 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product if you take blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or apixaban), diabetes medications, aspirin, salsalate, or choline magnesium trisalicylate before starting. These Moderate-severity interactions matter.

If you take medications processed by the CYP1A2 liver enzyme, flag it too, though that's a Minor concern.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, diabetes medications, or aspirin-like drugs, check with your pharmacist before using this product—the interactions are real, even if uncommon in practice. Otherwise, for a general audience with no medications, rosemary extract is generally well tolerated.

Talk to your pharmacist about your full medication list.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Joint-Ease, straight from the product label.

Brand Akasha Naturals
Net contents 20 Softgel(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 313114
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Joint-Ease by Akasha Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
20
IngredientAmount% DV
Rosemary Leaf Extract0 NP--
Tetrase0 NP--
A Proprietary Blend of350 mg--
Oleanolic Acid0 NP--

Other ingredients: Olive Oil, Gelatin, Glycerin, Yellow Beeswax, Water, Sodium Copper Chlorophyllin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Joint-Ease provides a plant-based option for effective joint comfort. This proprietary combination of selected plant components influences kinase signaling and the formation of certain substances, such as PGE2, that are associated with minor discomfort. Clinical testing suggests that Joint-Ease may offer a high degree of predicted cardiovascular, gastric, renal, and liver safety.

This product is non-GMO and gluten-free.

Selective kinase response modulators for joint comfort

Suggested/Recommended/Usage/Directions

Directions: Take one softgel two times daily with food or as directed by your healthcare practitioner.

Precautions

Caution: Do not use if pregnant or nursing, or taking anticoagulants. If taking other medication, consult your healthcare practitioner before use.

Keep out of the reach of children.

To report adverse events call 866-649-4334.

This product is manufactured in a facility that produces products containing soy, dairy, egg, nuts, fish and crustacean shellfish.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

U.S. Patent Nos. 7,205,151; 7,195,785; 7,270,835; 7,332,185.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Joint-Ease by Akasha Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Joint-Ease label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Joint-Ease by Akasha Naturals

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

A Proprietary Blend of

350 mg per serving

Other (inactive) ingredients: Olive Oil, Gelatin, Glycerin, Yellow Beeswax, Water, Sodium Copper Chlorophyllin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Joint-Ease by Akasha Naturals Drug Interactions

Want to check YOUR meds against Joint-Ease?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
372Drugs
212 Moderate 160 Minor

Ingredients driving the most interactions

Rosemary Leaf Extract 372

Individual Drug Interactions

The ingredients in Joint-Ease interact with 372 drugs. Click any drug to see the details.

1 of the 3 ingredients in Joint-Ease interact with drugs. Each result below shows which ingredient is responsible. Rosemary Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Joint-Ease with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Rosemary Leaf Extract6 drug types · 372 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that rosemary inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that rosemary extract can decrease blood glucose levels in diabetic models. However, research in humans is conflicting. Although rosemary powder decreased blood glucose levels in healthy adults, no change in blood glucose levels was seen in adults with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Aspirin

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Rosemary is reported to contain salicylates.

Likelihood Possible Evidence D
Choline Magnesium Trisalicylate (Trilisate)

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
Rosemary is reported to contain salicylate.

Likelihood Possible Evidence D
Salsalate (Disalcid)

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as salsalate.
Rosemary is reported to contain salicylate.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that rosemary induces CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Unlikely Evidence D
Rosemary Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Joint-Ease, from the product label.

Akasha Naturals

See all Akasha Naturals products
Name
Akasha Center for Integrative Medicine, LLC
Street Address
520 Arizona Ave
City
Santa Monica
State
CA
ZipCode
90401
Phone Number
866-649-4334
Web Address
www.akashanaturals.com
Pharmacist Counseling Corner

Joint-Ease by Akasha Naturals: Common Questions

Does Joint-Ease by Akasha Naturals interact with any medications?
Yes. Based on its ingredients, Joint-Ease has a known interaction with 372 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Joint-Ease contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does rosemary in this product actually help with joint pain?
The effectiveness data we have doesn't cover joint health specifically. Rosemary does show possibly effective evidence for memory, but we don't have reliable evidence to say whether it works for joints.
Can I take this while pregnant or breastfeeding?
Food amounts of rosemary are fine. At medicinal doses like those in a supplement, the safety data advises against it during pregnancy. For breastfeeding, there isn't enough data to know either way—talk with your doctor or pharmacist about what's right for you.
What are the actual side effects I might notice?
Serious side effects are uncommon. Topical allergic reactions (rashes, contact dermatitis) can happen, as can swelling of the lips or gums if used in the mouth. In sensitive people, it may cause sun sensitivity on the skin. The undiluted oil could theoretically trigger seizures, but that's rare.
Is this safe if I'm not on any medications?
Yes. Rosemary extract is generally well tolerated in people not taking medications, as long as you don't have a known allergy to herbs in the mint family. If you develop a rash or swelling, stop and talk to us.
What does Oleanolic Acid do in this formula?
We don't have data on file for Oleanolic Acid, so I can't tell you what role it plays or how it works. Your pharmacist at the counter might be able to look into the brand's own documentation if you ask.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Joint-Ease label
Go deeper

The Full Monographs Behind Joint-Ease’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rosemary

Interacts with 372 drugs

Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory, mood, and hair growth, but the evidenc...

Read the full Rosemary monograph →
Sources

Sources & How We Checked

Joint-Ease's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rosemary 20 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  5. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  6. Cartier LC, Lehrer A, Malo JL. Occupational asthma caused by aromatic herbs. Allergy 1996;51:647-9. DOI
  7. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
  8. Swain AR, Dutton SP, Truswell AS. Salicylates in foods. J Am Diet.Assoc 1985;85(8):950-60. DOI
  9. Zhu BT, Loder DP, Cai MX, et al. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis 1998;19(10):1821-7. PubMed
  10. Debersac P, Heydel JM, Amiot MJ, et al. Induction of cytochrome P450 and/or detoxication enzymes by various extracts of rosemary: description of specific patterns. Food Chem Toxicol 2001;39(9):907-18. PubMed
  11. Debersac P, Vernevaut MF, Amiot MJ, et al. Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver. Food Chem Toxicol 2001;39(2):109-17. PubMed
  12. Lee JJ, Jin YR, Lee JH, et al. Antiplatelet activity of carnosic acid, a phenolic diterpene from Rosmarinus officinalis. Planta Med 2007;73(2):121-7.
  13. Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
  14. Naemura A, Ura M, Yamashita T, et al. Long-term intake of rosemary and common thyme herbs inhibits experimental thrombosis without prolongation of bleeding time. Thromb Res 2008;122(4):517-22. PubMed
  15. Lee JJ, Jin YR, Lim Y, et al. Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. Vascul Pharmacol 2006;45:148-53. PubMed
  16. Bakirel, T., Bakirel, U., Keles, O. U., Ulgen, S. G., and Yardibi, H. In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. J Ethnopharmacol 2-28-2008;116(1):64-73. PubMed
  17. Erenmemisoglu, A., Saraymen, R., and Ustun, S. Effect of a Rosmarinus officinalis leave extract on plasma glucose levels in normoglycaemic and diabetic mice. Pharmazie 1997;52(8):645-646.
  18. Valones MAA, Silva ICG, Gueiros LAM, Leão JC, Caldas AF Jr, Carvalho AAT. Clinical assessment of rosemary-based toothpaste (Rosmarinus officinalis Linn.): A randomized controlled double-blind study. Braz Dent J. 2019;30(2):146-151. PubMed
  19. Quirarte-Báez SM, Zamora-Perez AL, Reyes-Estrada CA, et al. A shortened treatment with rosemary tea (rosmarinus officinalis) instead of glucose in patients with diabetes mellitus type 2 (TSD). J Popul Ther Clin Pharmacol. 2019;26(4):e18-e28.
  20. Al Jamal A. Effect of rosemary (Rosmarinus officinalis) on lipid profiles and blood glucose in human diabetic patients (type-2). African J. Biochem. Res. 2014;8(8):147-50. DOI

See these in context on the Rosemary monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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