Major interaction on record — check this product against your medications before combining. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

K2 MK-7 180 mcg & D3 5000 IU Ingredients & Drug Interactions

by Protocol For Life Balance

K2 MK-7 180 mcg & D3 5000 IU label
See full label image
Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking K2 MK-7 180 mcg & D3 5000 IU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

K2 MK-7 180 mcg & D3 5000 IU is a dietary supplement by Protocol For Life Balance with 2 active ingredients. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against K2 MK-7 180 mcg & D3 5000 IU by Protocol For Life Balance

Ask about any prescription or over-the-counter medication and we check it for interactions with K2 MK-7 180 mcg & D3 5000 IU by Protocol For Life Balance — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of K2 MK-7 180 mcg & D3 5000 IU by Protocol For Life Balance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients. Vitamin D3 at 5000 IU supports bone health and immune function.

Vitamin K2 at 180 mcg (as MK-7) works with vitamin D to help direct calcium to your bones and away from soft tissues — they work best together. The capsule also contains microcrystalline cellulose, hypromellose, and silicon dioxide as inactive ingredients to hold it together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Bone strength and vascular health support.
  • We looked for evidence on: Osteoporosis, Cardiovascular disease (CVD), Stroke, Wound healing, Bone metabolism, Calcium utilization — and 1 related terms.
  • The strongest evidence on file: Vitamin K is rated "Possibly Effective" for Osteoporosis (Natural Medicines).
  • Also on file: Vitamin K is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Stroke, Wound healing.

Vitamin K2 has solid evidence behind it for several uses. It's effective for treating vitamin K deficiency conditions and for managing warfarin therapy — though if you take warfarin, that's a reason to avoid this supplement, not to use it.

For bone health, the evidence is more mixed; it's rated possibly effective for osteoporosis. We don't have effectiveness data on file for Vitamin D3 in our system for this product, so I can't speak to what the research shows for it here.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin K taken by mouth is generally well tolerated. The most common side effects are mild — nausea, diarrhea, and stomach upset — and happen in a small number of people.

Serious reactions are very rare and happen almost only when vitamin K is given by injection, not by mouth. For pregnancy and breastfeeding, vitamin K2 is rated likely safe.

We don't have pregnancy or breastfeeding safety data on file for vitamin D3 in this product, so talk with your doctor or pharmacist about that ingredient if you're pregnant or nursing.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take any blood thinners, especially warfarin (Coumadin) — that's a Major interaction. We couldn't check vitamin D3 against the drug database, so if you're on any prescription medications at all, use the search tool below to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a solid pairing if you want to support bone health with vitamins D and K together. If you take warfarin or any other blood thinner, stop — this product isn't for you without your doctor's say-so.

Anyone else should check their medications with the tool on this page first, then talk to us if you have questions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about K2 MK-7 180 mcg & D3 5000 IU, straight from the product label.

Brand Protocol For Life Balance
Barcode (UPC) 707359103849
Net contents 60 Veg Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 337817
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Halal, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for K2 MK-7 180 mcg & D3 5000 IU by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
60
UPC/BARCODE
707359103849
IngredientAmount% DV
Vitamin D3125 mcg625%
Vitamin K2180 mcg--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 capsule daily with a fat-containing meal, or as directed by your healthcare practitioner.

Formula

How it works: Vitamins D3 and K2 have been extensively studied regarding their roles in calcium metabolism. Research indicates that a synergistic relationship exists between vitamin K2 and vitamin D3, especially in terms of bone strength and cardiovascular health. While vitamin D3 is recognized for its role in calcium absorption and metabolism, it is vitamin K2 that directs calcium to bones rather than joint spaces and arteries. This product is formulated with a clinically relevant dose of MK-7, a unique, soy-free form of vitamin K2 that has been shown to promote healthy vascular structures.

Crescent H (Halal)

180 mcg K2 / 5000 IU D3 MenaQ7 Vitamin K2 as MK-7

Triangle K (Kosher)

Precautions

Cautions/Interactions: Vitamin D should be used cautiously by those taking cardiac glycosides and anyone with hypercalcemia. Vitamin D supplements may interact with atorvastatin and thiazide diuretics. Vitamin K is contraindicated with warfarin or other anti-coagulant medications. If you are taking any of these prescription medications, consult your healthcare practitioner before using this product.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

Vascular Health Structural Support

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or sesame ingredients.

Storage

Store in a cool, dry place after opening.

Seals/Symbols

Crescent H (Halal)

Triangle K (Kosher)

FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

MenaQ7 is a registered trademark of NattoPharma ASA, Norway. Patents granted and pending.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

This bottle is made from 100% PCR (post-consumer recycled) resin.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

K2 MK-7 180 mcg & D3 5000 IU by Protocol For Life Balance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

K2 MK-7 180 mcg & D3 5000 IU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in K2 MK-7 180 mcg & D3 5000 IU by Protocol For Life Balance

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D3

125 mcg per serving Form: Cholecalciferol

Vitamin K2

Interacts with
2 drugs
180 mcg per serving Form: MenaQ7

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K2 monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

K2 MK-7 180 mcg & D3 5000 IU by Protocol For Life Balance Drug Interactions

Want to check YOUR meds against K2 MK-7 180 mcg & D3 5000 IU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K2 2

Individual Drug Interactions

The ingredients in K2 MK-7 180 mcg & D3 5000 IU interact with 2 drugs. Click any drug to see the details.

1 of the 2 ingredients in K2 MK-7 180 mcg & D3 5000 IU interact with drugs. Each result below shows which ingredient is responsible. Vitamin K2

Each ingredient & the kinds of drugs it affects

For each ingredient in K2 MK-7 180 mcg & D3 5000 IU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for K2 MK-7 180 mcg & D3 5000 IU, from the product label.

Protocol For Life Balance

See all Protocol For Life Balance products
Name
Protocol For Life Balance
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
www.protocolforlife.com
Pharmacist Counseling Corner

K2 MK-7 180 mcg & D3 5000 IU by Protocol For Life Balance: Common Questions

Does K2 MK-7 180 mcg & D3 5000 IU by Protocol For Life Balance interact with any medications?
Yes. Based on its ingredients, K2 MK-7 180 mcg & D3 5000 IU has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
K2 MK-7 180 mcg & D3 5000 IU contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
No — vitamin K2 in this product works against warfarin and can make it less effective. That's a Major interaction. Talk to your doctor before taking anything with vitamin K if you're on a blood thinner.
What are the side effects?
Vitamin K taken by mouth is usually well tolerated. Some people experience mild nausea, diarrhea, or stomach upset, but that's uncommon. Serious reactions are very rare and almost never happen with oral supplements.
Is this safe in pregnancy?
Vitamin K2 is rated likely safe in pregnancy. We don't have safety data on file for vitamin D3, so check with your doctor or pharmacist about that ingredient if you're pregnant or planning to be.
Why take both vitamin D and K together?
They work as a team. Vitamin D helps your body absorb and use calcium, and vitamin K2 directs that calcium into your bones and teeth rather than soft tissues. Together they support bone health better than either alone.
How much vitamin K is in one dose?
Each capsule has 180 micrograms of vitamin K2 as MK-7, which is a bioavailable form your body can use well.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if K2 MK-7 180 mcg & D3 5000 IU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

K2 MK-7 180 mcg & D3 5000 IU label
Go deeper

The Full Monographs Behind K2 MK-7 180 mcg & D3 5000 IU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

K2 MK-7 180 mcg & D3 5000 IU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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