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Dietary supplement

Konjac Root 2,000 mg Ingredients & Drug Interactions

by Herbal Secrets

Konjac Root 2,000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Konjac Root 2,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Konjac Root 2,000 mg is a dietary supplement by Herbal Secrets with 1 active ingredient. Its ingredients are commonly taken for weight loss and appetite control, constipation, high cholesterol.Based on those ingredients, 2,022 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Konjac. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Konjac Root 2,000 mg by Herbal Secrets

Ask about any prescription or over-the-counter medication and we check it for interactions with Konjac Root 2,000 mg by Herbal Secrets — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Konjac Root 2,000 mg by Herbal Secrets

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: konjac (also called glucomannan), a natural fiber from the konjac plant root at 2,000 mg per capsule. The capsule also includes inactive ingredients — microcrystalline cellulose, silica, magnesium stearate, and cellulose — which are standard binders and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: dietary fiber supplement for digestive health.
  • We looked for evidence on: Constipation, Hyperlipidemia, Obesity, Diabetes, appetite control, weight management.
  • The strongest evidence on file: Glucomannan is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Glucomannan is rated "Possibly Effective" for Diabetes, Hyperlipidemia.
  • Also on file: Glucomannan is rated "Insufficient Reliable Evidence To Rate" for Obesity.

Konjac has been rated Possibly Effective for constipation, diabetes, and high cholesterol (hyperlipidemia). For high blood pressure (hypertension), the evidence isn't strong enough to rate it — we simply don't hold reliable data on how well it works for that purpose.

The evidence, ingredient by ingredient Glucomannan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Konjac is generally well tolerated when you take it with plenty of water. The most common side effects are mild digestive complaints — bloating, gas, nausea, stomach pain, diarrhea, or constipation — especially if you take more than 3 grams a day.

The biggest caution: it can cause choking or blockage in your esophagus or gut, particularly if you swallow it dry or without enough liquid. This is rare but serious, so always drink plenty of water with it.

There isn't enough reliable safety data to know whether it's safe in pregnancy, and little is known about breastfeeding. Talk with your doctor or pharmacist before using it if you're pregnant or nursing.

Side effects, ingredient by ingredient Glucomannan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glucomannan.
  • The most serious interaction on file is rated Moderate.
  • For scale: 2,023 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or use the tool below if you take any oral medications. Konjac may reduce how well your body absorbs them — a Moderate concern.

Glyburide (a diabetes drug) is the best-studied example, but the effect could apply to many other oral drugs as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Konjac may help with constipation, blood sugar control, or cholesterol if the evidence holds for you — but it can slow how your body absorbs other medications. Always take it with plenty of water to avoid choking or blockage.

Check your medications with the tool on this page, and talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or take any oral drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Konjac Root 2,000 mg, straight from the product label.

Brand Herbal Secrets
Barcode (UPC) 810180023009
Net contents 90 Veggie Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 282843
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Konjac Root 2,000 mg by Herbal Secrets, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Veggie Capsule(s)
Maximum serving Sizes:
3 Veggie Capsule(s)
Servings per container
30
UPC/BARCODE
810180023009
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Konjac2000 mg--

Other ingredients: Microcrystalline Cellulose, Silica, Magnesium Stearate, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Herbal Secrets Konjac Root is an all-natural dietary supplement that is highly rich in vitamins, minerals and fiber while being low in calories. Glucomannan, a water soluble dietary fiber with extraordinary water-holding capacity is derived from konjac root. Glucomannan may offer benefits for those seeking to lose weight by creating a feeling of satiety or fullness through its water-binding effects. Konjac root also supports digestive health, helps to slow glucose absorption and promotes regular bowel movements.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take three (3) veggie capsules daily with a full glass of water or as directed by a health care professional.

Precautions

Caution: Not intended for use by persons under the age of 18, and pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Caution: Not intended for use by persons under the age of 18, and pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor before use. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Visit us online @ amazingnutrition.com

Vitamin Angels Proud supporter

Formulation

100% natural

Supports healthy weight management Promotes feelings of satiety Excellent source of fiber-supports digestive health Promotes regularity

Contains no: preservatives, artificial color, flavor or sweetener, sugar, milk, lactose, gluten, wheat, soy, yeast, fish or sodium.

Herbal Secrets An FDA regulated facility

Seals/Symbols

Made in the USA

Good Manufacturing Practice GMP Quality Product

FDA Statement of Identity

Natural Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Konjac Root 2,000 mg by Herbal Secrets label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Konjac Root 2,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Konjac Root 2,000 mg by Herbal Secrets

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Veggie Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Konjac

Interacts with
2,022 drugs
2000 mg per serving

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and mo...

Konjac monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Silica, Magnesium Stearate, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Konjac Root 2,000 mg by Herbal Secrets Drug Interactions

Want to check YOUR meds against Konjac Root 2,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,022Drugs
2,022 Moderate

Ingredients driving the most interactions

Konjac 2,022

Individual Drug Interactions

The ingredients in Konjac Root 2,000 mg interact with 2,022 drugs. Click any drug to see the details.

1 of the 1 ingredient in Konjac Root 2,000 mg interact with drugs. Each result below shows which ingredient is responsible. Konjac

Each ingredient & the kinds of drugs it affects

For each ingredient in Konjac Root 2,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Konjac1 drug type · 2,022 drugs

Oral Drugs

Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. In addition, animal research demonstrates this effect on amoxicillin, but shows increased absorption of metronidazole. This mouse model also demonstrates that metronidazole elimination is prolonged, but amoxicillin elimination is enhanced by 38%; glucomannan may also affect the distribution of some drugs. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.

Likelihood Probable Evidence B
Konjac full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Konjac Root 2,000 mg, from the product label.

Herbal Secrets

See all Herbal Secrets products
Name
Herbal Secrets
Street Address
629 Grove Street
City
Jersey City
State
NJ
ZipCode
07310
Web Address
amazingnutrition.com
Pharmacist Counseling Corner

Konjac Root 2,000 mg by Herbal Secrets: Common Questions

Does Konjac Root 2,000 mg by Herbal Secrets interact with any medications?
Yes. Based on its ingredients, Konjac Root 2,000 mg has a known interaction with 2,022 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Konjac Root 2,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is konjac and why is it in this supplement?
Konjac is a fiber from the root of the konjac plant that absorbs water and becomes thick and gel-like in your digestive system. That bulking action is why it's used to help with constipation and may support blood sugar and cholesterol levels.
Can I take this with my other medications?
Maybe — it depends on which drugs you take. Konjac can slow the absorption of oral medications, which means they might not work as well. Check your exact medications with the interaction tool on this page, and talk to your pharmacist before you start.
What's the most common side effect?
Bloating, gas, and stomach upset are the most common — especially if you take more than 3 grams a day. The more serious risk is choking or intestinal blockage if you don't drink enough water with it, which is rare but why plenty of liquid is essential.
Is it safe to use while pregnant or breastfeeding?
There isn't enough reliable safety data for either. Talk with your doctor before using it during pregnancy or while breastfeeding so you can make a decision that's right for your situation.
Will this help my high blood pressure?
The evidence isn't established. We hold reliable data showing konjac may help with constipation, blood sugar, and cholesterol, but not for blood pressure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Konjac Root 2,000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Konjac Root 2,000 mg label
Go deeper

The Full Monographs Behind Konjac Root 2,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glucomannan

Interacts with 2,022 drugs

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is gener...

Read the full Glucomannan monograph →
Sources

Sources & How We Checked

Konjac Root 2,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glucomannan 15 references
  1. Henry DA, Mitchell AS, Aylward J, et al. Glucomannan and risk of oesophageal obstruction. Br Med J 1986;292:591-2. PubMed
  2. Shima K, Tanaka A, Ikegami H, et al. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. Horm Metab Res 1983;15:1-3. PubMed
  3. Villaverde, A. F., Benlloch, S., Berenguer, M., Miguel, Rayon J., Pina, R., and Berenguer, J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (amorphophalus konjac). J Hepatol. 2004;41(6):1061-1062. PubMed
  4. Yoshida, M., Vanstone, C. A., Parsons, W. D., Zawistowski, J., and Jones, P. J. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur.J Clin Nutr. 2006;60(4):529-537. PubMed
  5. Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., and Volek, J. S. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber
  6. Vanderbeek, P. B., Fasano, C., O'Malley, G., and Hornstein, J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol.(Phila) 2007;45(1):80-82. PubMed
  7. Bernstein, J. A., Crandall, M. S., and Floyd, R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma 2007;44(8):675-680. PubMed
  8. Shichijo, K., Kobayashi, Y., Fueki, R., Shimoyama, K., and Masaya, M. [2 cases of konjac bronchial asthma found outside the "konnyaku" producing district]. Arerugi 1969;18(2):97-100.
  9. Carabin IG, Lyon MR, Wood S, et al. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J 2009;8:9. PubMed
  10. Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev
  11. Lyon M, Wood S, Pelletier X, et al. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet 2011;24(4):351-9. PubMed
  12. Han Y, Zhang L, Liu XQ, Zhao ZJ, Lv LX. Effect of glucomannan on functional constipation in children: a systematic review and meta-analysis of randomised controlled trials. Asia Pac J Clin Nutr 2017;26(3):471-7.
  13. Health Canada Safety Alert. Health Canada Advises Canadians that natural health products containing glucomannan may cause serious choking if used with insufficient fluid. January 29, 2010. Alert # RA-110003825. https://healthycanadians.gc.ca/recall-alert-
  14. Mortensen A, Aguilar F, Crebelli, et al. EFSA Panel on Food Additives and Nutrient Sources added to Food. Re-evaluation of konjac gum (E 425 i) and konjac glucomannan (E425 ii) as food additives. EFSA Journal 2017;15(6):4864.
  15. Zhang Y, Aldamarany WAS, Song G, et al. Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement. Int J Biol Macromol 2023;251:126306. PubMed

See these in context on the Glucomannan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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