Kyolic Aged Garlic Extract Formula 100 Ingredients & Drug Interactions
by Wakunaga
What is this page for?
First and foremost: checking Kyolic Aged Garlic Extract Formula 100 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Kyolic Aged Garlic Extract Formula 100 is a dietary supplement by Wakunaga with 1 active ingredient. Its ingredients are commonly taken for high blood pressure, high cholesterol, heart health.Based on those ingredients, 989 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Aged Garlic Bulb Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Kyolic Aged Garlic Extract Formula 100 by Wakunaga
Ask about any prescription or over-the-counter medication and we check it for interactions with Kyolic Aged Garlic Extract Formula 100 by Wakunaga — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Kyolic Aged Garlic Extract Formula 100 by Wakunaga
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: aged garlic bulb extract powder. Aged garlic extract is garlic that's been fermented or aged over time, a process that changes its chemical makeup and is thought to affect how it works in your body.
The inactive ingredients are whey, alginic acid, silica, cellulose, and magnesium stearate — standard tablet binders and fillers.
Does it work?
Moderate evidence
The evidence we hold shows that aged garlic extract is possibly effective for several conditions: high blood pressure (hypertension), diabetes, high cholesterol and plaque buildup (atherosclerosis), gum disease (periodontitis), and fatty liver disease (nonalcoholic fatty liver disease or NAFLD). 'Possibly effective' means there's some human research suggesting it may help, but the evidence isn't conclusive — more or better studies are needed to be sure.
How safe is it?
Well-documented data
Garlic taken by mouth is generally well tolerated. The most common side effects are mild: stomach upset, gas, bloating, body odor, and bad breath.
Some people report allergic reactions, itching, flushing, or acne. A few rare cases describe rashes or mouth ulcers.
One important caution is that garlic supplements may increase your bleeding risk — this matters if you bruise easily or have a bleeding disorder, and it's a key reason to tell your doctor or pharmacist if you're taking this alongside blood thinners. Food amounts of garlic are likely fine, but concentrated supplement doses haven't been well studied, so avoid them unless your doctor approves.
Meds to double-check
Moderate interaction found
Before taking Kyolic Aged Garlic Extract Formula 100, double-check with your pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel), blood pressure medications, diabetes drugs, HIV protease inhibitors, tacrolimus, or any drug your doctor says is processed by your liver. Garlic can change how all of these work.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you're taking blood thinners, diabetes medications, blood pressure drugs, HIV protease inhibitors, or tacrolimus, talk to your pharmacist or doctor before starting this product — garlic can significantly affect how those work. Otherwise, for general cardiovascular or metabolic support where the evidence suggests it may help, aged garlic extract is generally well tolerated, though stomach upset and bad breath are common.
Use the interaction checker on this page with your exact medication list.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Kyolic Aged Garlic Extract Formula 100, straight from the product label.
| Brand | Wakunaga |
|---|---|
| Barcode (UPC) | 023542100311 |
| Net contents | 100 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2025 |
| DSLD ID | 326198 |
| Product type | Botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Kyolic Aged Garlic Extract Formula 100 by Wakunaga, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Aged Garlic Bulb Extract, Powder | 600 mg | -- |
Other ingredients: Whey, Alginic Acid, Silica, Cellulose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Formula 100 supports your cardiovascular system by maintaining circulatory function and overall heart health. Kyolic Aged Garlic Extract (AGE) starts with organically grown garlic. It is then aged using a proprietary process which removes odor-causing compounds attributed to raw garlic and increases the bioavailable beneficial compounds.
Contains Aged Garlic Extract:
Precautions
Do not use if outer safety band or inner seal is broken or missing.
Keep out of reach of children.
Whey derived from milk.
Storage
Store in a cool, dry place with lid tightly closed.
General Statements
Scan ME
Doctor Developed
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
GMP Certified
Formulation
Cardiovascular health Original Odorless Organically Grown
Odorless Organically Grown
Clinically studied Quality tested
Free of: GMOs, gluten, sodium, yeast, soy, sugar, preservatives, artificial colors or flavors.
FDA Statement of Identity
Herbal Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: Take two tablets with a meal twice daily.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Kyolic Aged Garlic Extract Formula 100 by Wakunaga label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Kyolic Aged Garlic Extract Formula 100 by Wakunaga
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container50 Amounts shown are per serving.
Aged Garlic Bulb Extract, Powder
Interacts with989 drugs
Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usuall...
Aged Garlic Bulb Extract, Powder monograph & interactionsOther (inactive) ingredients: Whey, Alginic Acid, Silica, Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Kyolic Aged Garlic Extract Formula 100 by Wakunaga Drug Interactions
HelloPharmacist Interaction Report
Kyolic Aged Garlic Extract Formula 100 contains one active ingredient — aged garlic bulb extract — that interacts with a significant number of medications.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs like warfarin (Coumadin), where garlic may increase bleeding risk by thinning the blood further and raising your INR (a measure of how thin your blood is). This is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Garlic also interacts with drugs that lower blood pressure (antihypertensive drugs) — taking both together might drop your pressure too low. It can increase low blood sugar (hypoglycemia) risk if you're on diabetes medications, and it affects how your body breaks down certain HIV protease inhibitors and tacrolimus (an immunosuppressant used after transplants), potentially changing their levels in your blood.
Additionally, garlic may alter levels of other drugs processed by your liver's CYP3A4 and CYP2E1 enzymes — a Moderate-severity interaction that could make those medications less or more effective than intended.
No other ingredients in this product have documented interactions. Altogether, these interactions span 977 individual medications.
Because garlic's effects vary by preparation and dose, check your exact medications with the search tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Kyolic Aged Garlic Extract Formula 100?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Kyolic Aged Garlic Extract Formula 100 interact with 989 drugs. Click any drug to see the details.
1 of the 1 ingredient in Kyolic Aged Garlic Extract Formula 100 interact with drugs. Each result below shows which ingredient is responsible. Aged Garlic Bulb Extract, Powder
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Bulb Extract, Powder + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Aged Garlic Bulb Extract, Powder + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Bulb Extract, Powder + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Bulb Extract, Powder + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Bulb Extract, Powder + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Aged Garlic Bulb Extract, Powder + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Bulb Extract, Powder + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Aged Garlic Bulb Extract, Powder + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Aged Garlic Bulb Extract, Powder + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Aged Garlic Bulb Extract, Powder + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Kyolic Aged Garlic Extract Formula 100 — through 1 ingredient. Tap an ingredient for the detail:
Aged Garlic Bulb Extract, PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Aged Garlic Bulb Extract, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Kyolic Aged Garlic Extract Formula 100 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Aged Garlic Bulb Extract, Powder
Anticoagulant/Antiplatelet Drugs
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time.
Antidiabetes Drugs
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research suggests that garlic and garlic extract lower blood glucose levels in healthy and diabetic individuals.
Antihypertensive Drugs
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
In human research, both garlic and garlic extracts have blood pressure-lowering effects.
Atazanavir (Reyataz)
Theoretically, garlic might decrease levels and effects of atazanavir.
In a case report, a patient consuming six stir-fried garlic cloves three times weekly developed suboptimal atazanavir levels and increases in HIV viral load. While the exact cause of this interaction is unclear, there is speculation that garlic might decrease the intestinal absorption of atazanavir or increase its metabolism by inducing cytochrome P450 3A4 (CYP3A4). Until more is known, advise patients not to consume large amounts of garlic while taking atazanavir.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Garlic might increase levels of drugs metabolized by CYP2E1.
Clinical research suggests garlic oil can inhibit the activity of CYP2E1 by 39%. Use garlic oil cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Some human research suggests that garlic may induce INTESTINAL CYP3A4, reducing levels of drugs metabolized by this enzyme. This is primarily based on a study showing that taking a specific allicin-containing garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induced CYP3A4 in the gut mucosa. Another study shows that giving docetaxel intravenously, bypassing the CYP3A4 enzymes in the gut mucosa, along with the same specific garlic product for 12 consecutive days, does not affect docetaxel levels. Conversely, there is concern that garlic may inhibit HEPATIC CYP3A4. In a single case report, increased tacrolimus levels and liver injury occurred in a liver transplant patient after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. Several other studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Isoniazid
Theoretically, garlic might decrease levels of isoniazid.
Animal research suggests that an aqueous extract of garlic reduces isoniazid levels by about 65%. Garlic reduced the maximum concentration (Cmax) and area under the curve (AUC), but not the half-life, of isoniazid. This suggests that garlic extract might inhibit isoniazid absorption across the intestinal mucosa; however, the exact mechanism of this potential interaction is not known.
Protease Inhibitors (Pis)
Theoretically, garlic products containing allicin might decrease levels of PIs.
Protease inhibitors are metabolized by cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4, reducing plasma levels of protease inhibitors. This is primarily based on a study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces levels of saquinavir, a PI, by approximately 50%. It is speculated that the allicin constituent induce CYP3A4 in the gut mucosa. Several studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Saquinavir (Fortovase, Invirase)
Theoretically, garlic containing allicin might decrease levels of saquinavir.
Saquinavir is a substrate of cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4 and cause subtherapeutic levels of saquinavir. This is primarily based on a pharmacokinetic study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induces CYP3A4 in the gut mucosa. Several pharmacokinetic studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin. Until more is known about this potential interaction, use garlic containing allicin cautiously in patients taking saquinavir.
Sofosbuvir (Sovaldi)
Theoretically, taking garlic with sofosbuvir might decrease its effectiveness.
Animal research in rats shows that giving aged garlic extract 120 mg/kg orally daily for 14 days decreases the area under the concentration time curve (AUC) after a single sofosbuvir dose of 40 mg/kg by 36%, increases the clearance by 63%, and decreases the plasma concentrations at 1 and 8 hours by 35% and 58%, respectively. This interaction is hypothesized to be due to induction of intestinal P-glycoprotein expression by garlic.
Tacrolimus (Prograf)
Theoretically, garlic might increase levels of tacrolimus.
In one case report, a liver transplant patient taking tacrolimus experienced increased tacrolimus levels and liver injury after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. It is speculated that garlic inhibited hepatic cytochrome P450 3A4 (CYP3A4), which increased plasma levels of tacrolimus.
Warfarin (Coumadin)
Theoretically, garlic might increase the risk of bleeding with warfarin.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time. In addition, there is a report of two patients who experienced an increase in a previously stabilized international normalized ratio (INR) with concomitant garlic and warfarin use. However, this report has been subsequently debated due to limited clinical information. Other clinical studies have not identified an effect of garlic on INR, warfarin pharmacokinetics, or bleeding risk. More evidence is needed to determine the safety of using garlic with warfarin.
Brand information
Manufacturer and brand details for Kyolic Aged Garlic Extract Formula 100, from the product label.
Wakunaga
See all Wakunaga products- Name
- Wakunaga of America Co., Ltd.
- City
- Mission Viejo
- State
- CA
- ZipCode
- 92691
- Phone Number
- 800-421-2998
- Web Address
- www.kyolic.com
Kyolic Aged Garlic Extract Formula 100 by Wakunaga: Common Questions
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The Full Monographs Behind Kyolic Aged Garlic Extract Formula 100’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Kyolic Aged Garlic Extract Formula 100's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 154 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Garlic 154 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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