L-Glycine 1,000 mg Ingredients & Drug Interactions
by Dr. Mercola
What is this page for?
First and foremost: checking L-Glycine 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Glycine 1,000 mg is a dietary supplement by Dr. Mercola with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Glycine 1,000 mg by Dr. Mercola
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Glycine 1,000 mg by Dr. Mercola — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Glycine 1,000 mg by Dr. Mercola
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 1 active ingredient: L-glycine at 1,000 mg per capsule. Glycine is a simple amino acid that your body uses for many functions, including muscle and nervous system support.
The capsule also holds inactive ingredients (rice flour, hydroxypropyl methylcellulose, and silicon dioxide) that serve as fillers and capsule material.
Does it work?
Insufficient evidence
L-glycine is rated possibly effective for schizophrenia based on available evidence. For other conditions listed — 3-phosphoglycerate dehydrogenase deficiency, attention deficit-hyperactivity disorder (ADHD), benign prostatic hyperplasia (BPH), and cystic fibrosis — there isn't enough reliable evidence in our data to determine whether it works.
How safe is it?
Well-documented data
L-glycine is generally well tolerated at typical doses, but long-term safety data are limited. A small number of trial participants reported mild sedation, irritability, insomnia, fatigue, memory impairment, headache, and sensory issues; gastrointestinal side effects like soft stools, nausea, vomiting, and upper stomach discomfort have also been reported rarely.
These symptoms resolve quickly when you stop taking the supplement. There isn't enough reliable safety data during pregnancy, so it's best avoided unless your doctor approves, and caution is advised while breastfeeding.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril) for schizophrenia, check with your doctor or pharmacist before starting L-glycine. A small study suggests adding glycine may worsen schizophrenia symptoms when combined with clozapine.
The bottom line
Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
L-glycine may be worth considering if you're exploring support for schizophrenia symptoms, but the evidence for other uses listed isn't established in our data. If you take clozapine for schizophrenia, do not add this supplement without checking with your doctor or pharmacist first — the combination may actually worsen your symptoms.
Talk it over with your healthcare provider before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Glycine 1,000 mg, straight from the product label.
| Brand | Dr. Mercola |
|---|---|
| Barcode (UPC) | 810094211998 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 20, 2024 |
| DSLD ID | 308757 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Glycine 1,000 mg by Dr. Mercola, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Glycine | 1000 mg | -- |
Other ingredients: Rice Flour, Hydroxypropyl Methylcellulose, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage
Suggested use: Adults, as a dietary supplement, take two (2) capsules daily.
Precautions
Keep out of reach of children.
Do not use if safety seal is broken.
If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Energy production Mitochondrial health Brain & cognitive function
Formula
L-glycine 1,000 mg per serving
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Providing quality products since 2001.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Glycine 1,000 mg by Dr. Mercola label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Glycine 1,000 mg by Dr. Mercola
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
L-Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
L-Glycine monograph & interactionsOther (inactive) ingredients: Rice Flour, Hydroxypropyl Methylcellulose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
L-Glycine 1,000 mg by Dr. Mercola Drug Interactions
HelloPharmacist Interaction Report
Dr.
Mercola's L-Glycine 1,000 mg does interact with at least one medication. The product contains L-glycine, which has a documented Moderate interaction with clozapine (Clozaril), an antipsychotic used for schizophrenia.
Adding glycine to clozapine therapy may worsen schizophrenia symptoms based on a small clinical study, though the exact mechanism isn't fully understood.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 1 individual medication. If you take clozapine, check with your doctor or pharmacist before starting this supplement — the combination may reduce how well your antipsychotic works.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Glycine 1,000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Glycine 1,000 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Glycine 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. L-Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with L-Glycine 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-glycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full L-glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Glycine 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for L-Glycine 1,000 mg, from the product label.
Dr. Mercola
See all Dr. Mercola products- Name
- NHP
- Street Address
- 125 SW 3rd Place
- City
- Cape Coral
- State
- FL
- ZipCode
- 33991
- Phone Number
- (877) 985-2696
L-Glycine 1,000 mg by Dr. Mercola: Common Questions
Does L-Glycine 1,000 mg by Dr. Mercola interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is L-glycine safe to take during pregnancy or while breastfeeding?
What side effects might I notice?
Does this product actually work for schizophrenia?
How much long-term safety data exists for L-glycine?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Glycine 1,000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Glycine 1,000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Glycine 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC