L-Histidine HCl Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Histidine HCl against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Histidine HCl is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for skin conditions like eczema, anemia related to kidney disease, allergy and inflammation support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of L-Histidine HCl by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-histidine hydrochloride, an amino acid your body uses to build proteins and produce histamine, a chemical messenger involved in immune and inflammatory responses. The powder form allows you to measure and mix the dose yourself.
Does it work?
Moderate evidence
The evidence we hold shows L-histidine is possibly effective for cholera. For other uses — atopic dermatitis (eczema), kidney failure, and rheumatoid arthritis — the evidence is insufficient to know whether it works.
If you're considering this supplement for one of those conditions, talk with your doctor about what the broader research shows and whether a trial makes sense for you.
How safe is it?
Some data gaps
L-histidine from dietary sources (like meat and poultry) is a normal part of nutrition and well tolerated. The safety of higher supplement doses, however, has not been well studied.
The safety data advises caution with supplemental amounts unless your doctor recommends it. No adverse effects are documented in our data.
L-histidine is likely safe during pregnancy and lactation, though you should still discuss any supplement use with your obstetrician or midwife.
Meds to double-check
No known interactions
No interactions are documented in our data for L-histidine. That doesn't mean none exist — just that we have no monograph evidence for drug interactions with this ingredient.
Check your medications through the tool on this page to be thorough.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and some safety-information gaps remain.
L-histidine is an amino acid your body normally gets from protein-rich foods. If your doctor suggests a supplement for a specific reason — like cholera — this form is a straightforward way to take it.
Because supplement doses haven't been extensively studied, talk with your pharmacist or doctor before starting, especially if you have kidney disease or are pregnant.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Histidine HCl, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X000J41BP1 |
| Net contents | 500 Gram(s); 17.6 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Jun 20, 2024 |
| DSLD ID | 312164 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Histidine HCl by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Histidine Hydrochloride | 500 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
BulkSupplements.com Clean & pure bulk supplements
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
Formulation
Free of: Added sugar, soy, dairy, yeast, gluten, additives
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 500 mg (about 1/5 tsp) once daily, or as directed by a physician.
Storage
Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place
General Statements
Use an accurate milligram scale. New
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Histidine HCl by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Histidine HCl by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size500 mg Dosage formPowder Servings per container1000 Amounts shown are per serving.
L-Histidine Hydrochloride
No knowninteractions
Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from...
L-Histidine Hydrochloride monograph & interactionsL-Histidine HCl by BulkSupplements.com Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in L-Histidine HCl. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for L-Histidine HCl, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
L-Histidine HCl by BulkSupplements.com: Common Questions
Does L-Histidine HCl by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is L-histidine safe to take while I'm pregnant or breastfeeding?
What does L-histidine do in my body?
Can L-histidine help with eczema or rheumatoid arthritis?
Why does the label say I should avoid this unless my doctor recommends it?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Histidine HCl is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Histidine HCl’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Histidine HCl's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC