L-Lysine 1000 mg Ingredients & Drug Interactions
by up&up
What is this page for?
First and foremost: checking L-Lysine 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Lysine 1000 mg is a dietary supplement by up&up with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Lysine 1000 mg by up&up
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine 1000 mg by up&up — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Lysine 1000 mg by up&up
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-lysine 1000 mg per tablet. The remaining ingredients — L-lysine hydrochloride, microcrystalline cellulose, dicalcium phosphate, stearic acid, calcium silicate, and magnesium stearate — are inactive excipients that help form and stabilize the tablet.
Does it work?
Moderate evidence
L-lysine is possibly effective for cold sores (herpes labialis). For other uses listed here — supporting child growth, healing pressure ulcers, and helping diabetic foot ulcers — there isn't enough reliable evidence yet to rate how well it works.
If cold sores are what you're targeting, the evidence supports giving it a try; for other purposes, talk with your doctor about whether it makes sense for you.
How safe is it?
Well-documented data
Lysine is generally well tolerated at typical doses. At high amounts, though, it may cause stomach upset, and we don't have long-term safety data for supplement use.
During pregnancy, getting lysine from food is fine, but supplement safety hasn't been well studied — check with your doctor first. There isn't enough reliable information on supplement use while breastfeeding, so caution is advised.
The most common side effects from oral lysine are abdominal pain, diarrhea, and indigestion. There is one case report of oral lysine linked to a kidney inflammation that progressed to chronic kidney damage, though this is rare.
Meds to double-check
Minor interactions only
If you take a 5-HT4 agonist (a medication for digestive motility), check with your doctor or pharmacist before adding this product — lysine may reduce how well it works. For all other medications we could check, no interactions are documented in our data.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
L-lysine is possibly effective for cold sores and is generally well tolerated at normal doses. If you're pregnant, breastfeeding, or take a 5-HT4 agonist, talk with your doctor or pharmacist first.
At high doses or long-term, stomach upset is a risk, and safety data is limited.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Lysine 1000 mg, straight from the product label.
| Brand | up&up |
|---|---|
| Barcode (UPC) | 070030625504 |
| Net contents | 200 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Nov 21, 2020 |
| DSLD ID | 239867 |
| Product type | Amino Acid/protein |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Lysine 1000 mg by up&up, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 Calorie(s) | -- |
| L-Lysine | 1 Gram(s) | -- |
Other ingredients: L-Lysine Hydrochloride, Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Calcium Silicate, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
L-lysine 1000 mg per serving
Formulation
Helps support healthy skin, collagen and tissue maintenance
No yeast, wheat, milk or milk derivatives, lactose, sugar, preservatives, artificial flavor, sodium. Gluten free
Restore L-lysine is an essential amino acid that cannot be made by the body. Amino acids perform a variety of functions and form the basis for protein. Proteins play a role in constructing and maintaining the critical structures of the body. L-lysine also supports the health of the lips, in addition to the health and integrity of the skin.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
2015 Target Brands, Inc.
General Statements
Guest services 1-800-910-6874
Suggested/Recommended/Usage/Directions
Suggested use: Adults, take two tablets daily with the meal of your choice. As a reminder, discuss the supplements and medications you take with your healthcare provider.
Precautions
Keep out of reach of children.
Caution: If you are pregnant or nursing a baby or if you are taking medication, planning any medical procedure, or have a medical condition, consult your doctor before taking this product.
Discontinue use and consult your doctor if any adverse reactions occur.
Storage
Store in a dry place at room temperature (59 degrees F - 86 degrees F).
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Lysine 1000 mg by up&up label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Lysine 1000 mg by up&up
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.
L-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: L-Lysine Hydrochloride, Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Calcium Silicate, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
L-Lysine 1000 mg by up&up Drug Interactions
HelloPharmacist Interaction Report
L-Lysine 1000 mg by up&up interacts with one class of medications.
Through its lysine content, this product may reduce the effects of 5-HT4 agonists — a group of drugs sometimes used for digestive motility. The concern is based on animal research showing that lysine acts as a partial antagonist at the serotonin receptor 4 site, meaning it could theoretically blunt how these medications work.
Read the full breakdown — every affected drug type, severity by severity
Although this is a documented interaction, it's classified as Minor in severity. If you take a 5-HT4 agonist, check with your doctor or pharmacist before starting lysine to confirm whether it's the right choice for you.
Alone, lysine has no interactions are documented in our data with any other medications. Use the search tool on this page to verify your exact drugs.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Lysine 1000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Lysine 1000 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Lysine 1000 mg interact with drugs. Each result below shows which ingredient is responsible. L-Lysine
TegaserodZelnorm
How Tegaserod interacts with L-Lysine 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full L-lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Lysine 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for L-Lysine 1000 mg, from the product label.
up&up
See all up&up products- Name
- Target Corporation
- City
- Minneapolis
- State
- MN
- ZipCode
- 55403
- Phone Number
- 1-800-910-6874
- Web Address
- Target.com
L-Lysine 1000 mg by up&up: Common Questions
Does L-Lysine 1000 mg by up&up interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does L-lysine actually work for cold sores?
Can I take this while pregnant or breastfeeding?
What are the most common side effects?
Is this supplement safe long-term?
Can L-lysine help with diabetic foot ulcers or pressure sores?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Lysine 1000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Lysine 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Lysine 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC