L-Lysine 500 mg Ingredients & Drug Interactions
by Bluebonnet
What is this page for?
First and foremost: checking L-Lysine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Lysine 500 mg is a dietary supplement by Bluebonnet with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Lysine 500 mg by Bluebonnet
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine 500 mg by Bluebonnet — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Lysine 500 mg by Bluebonnet
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-Lysine, an amino acid your body naturally makes and gets from foods like chicken, cheese, and beans. The capsule itself holds inert fillers — cellulose, silicon dioxide, magnesium stearate, hypromellose, and purified water — to hold the lysine and keep it stable.
Does it work?
Moderate evidence
L-Lysine is possibly effective for cold sores (herpes labialis) — the evidence suggests it may help, though it's not airtight. For pressure ulcers, diabetic foot ulcers, and supporting child growth, the evidence we hold isn't strong enough to rate it either way.
How safe is it?
Well-documented data
L-Lysine is generally well tolerated at normal doses. At higher amounts, some people report stomach upset, abdominal pain, diarrhea, or indigestion.
Long-term safety at supplement doses hasn't been thoroughly studied. Supplements differ from food — the safety data for L-Lysine supplements in pregnancy and breastfeeding isn't well established.
If you're pregnant or nursing, check with your doctor before starting, since the evidence isn't there to say it's safe or unsafe. One rare case report linked very high-dose oral lysine to kidney inflammation, though this is uncommon.
Meds to double-check
Minor interactions only
If you take a 5-HT4 agonist like prucalopride for bowel movement, check with your pharmacist before starting L-Lysine — it may reduce the drug's effect (Minor severity).
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
L-Lysine may help with cold sores and is generally well tolerated. If you take a 5-HT4 agonist for bowel movement, check with us first — lysine might reduce how well it works.
Pregnant or breastfeeding? Talk to your doctor, since supplement safety data is limited.
Ask your pharmacist to run your medications through our interaction checker.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Lysine 500 mg, straight from the product label.
| Brand | Bluebonnet |
|---|---|
| Barcode (UPC) | 743715000520 |
| Net contents | 50 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2025 |
| DSLD ID | 332522 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Lysine 500 mg by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Lysine | 500 mg | -- |
Other ingredients: Hypromellose, Water, Purified, Cellulose, Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Bluebonnet's L-Lysine 500 mg Vegetable Capsules are formulated with the free-form amino acid L-lysine HCl from Ajinomoto to help support immune function and collagen synthesis.
Bluebonnet's KOF-K Certification #K-0000700
AjiPure Amino Acids
K Parve (Kosher)
Formulation
May support Immune function Collagen synthesis
Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans and sesame. Also free of corn, gluten, barley, rice, sodium and sugar.
Beauty & immune support
Vegan
Made with non GMO ingredients Gluten free
Precautions
Caution: For adults only. Keep out of reach of children.
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
Made with non GMO ingredients
K Parve (Kosher)
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take one capsule daily or as directed by a healthcare practitioner.
Storage
Store tightly closed in a cool, dry place
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Lysine 500 mg by Bluebonnet label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Lysine 500 mg by Bluebonnet
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.
L-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: Hypromellose, Water, Purified, Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
L-Lysine 500 mg by Bluebonnet Drug Interactions
HelloPharmacist Interaction Report
Bluebonnet's L-Lysine 500 mg has one documented interaction.
L-Lysine may reduce how well 5-HT4 agonists work — drugs like prucalopride (Motegrity) that help with bowel movement. Animal studies suggest lysine blocks the serotonin receptor these medications rely on, though the clinical importance isn't fully clear.
Read the full breakdown — every affected drug type, severity by severity
No other medication interactions are documented in our data for this ingredient. That said, absence of documented interactions isn't a guarantee none exist.
Run your exact medications through the checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Lysine 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Lysine 500 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Lysine 500 mg interact with drugs. Each result below shows which ingredient is responsible. L-Lysine
TegaserodZelnorm
How Tegaserod interacts with L-Lysine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full L-lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Lysine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for L-Lysine 500 mg, from the product label.
Bluebonnet
- Name
- Bluebonnet Nutrition Corporation
- Street Address
- 12915 Dairy Ashford
- City
- Sugar Land
- State
- Texas
- ZipCode
- 77478
- Web Address
- bluebonnetnutrition.com
L-Lysine 500 mg by Bluebonnet: Common Questions
Does L-Lysine 500 mg by Bluebonnet interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does L-Lysine really work for cold sores?
What are the side effects?
Is it safe if I'm pregnant or breastfeeding?
How much L-Lysine should I take?
Can I take this with my other supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Lysine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Lysine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Lysine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC