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Dietary supplement

L-Lysine Ingredients & Drug Interactions

by NutraBio

L-Lysine label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Lysine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

L-Lysine is a dietary supplement by NutraBio with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against L-Lysine by NutraBio

Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine by NutraBio — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of L-Lysine by NutraBio

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: L-Lysine HCl, an amino acid your body uses to build and repair proteins. L-lysine is essential — your body can't make it, so you have to get it from food or supplements.

It's found naturally in meat, fish, dairy, and legumes.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: amino acid nutrient supplement.
  • We looked for evidence on: Herpes labialis (cold sores), Genital herpes, Protein synthesis, Collagen formation.
  • The strongest evidence on file: Lysine is rated "Possibly Effective" for Herpes labialis (cold sores) (Natural Medicines).

L-lysine is possibly effective for cold sores (herpes labialis). The evidence supports its use for this purpose, though it's not a cure — it may help manage outbreaks or duration.

For other uses listed here — child growth, pressure ulcers, and diabetic foot ulcers — there isn't enough reliable evidence yet to know whether it works.

The evidence, ingredient by ingredient Lysine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-lysine is generally well tolerated at typical doses. However, high amounts may cause stomach upset, abdominal pain, diarrhea, or indigestion.

Long-term safety of supplement doses hasn't been well studied. There's one case report of oral lysine linked to kidney inflammation that progressed to chronic kidney disease, though this is rare.

Supplement safety in pregnancy and breastfeeding hasn't been well studied. Lysine from food is fine, but if you're pregnant or breastfeeding and considering a supplement, talk with your doctor first to decide what's right for you.

Side effects, ingredient by ingredient Lysine

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lysine.
  • The most serious interaction on file is rated Minor.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take a 5-HT4 agonist — a drug used for certain digestive or bowel conditions — check with your doctor or pharmacist before taking L-lysine, since the supplement may reduce its effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

L-lysine may help manage cold sores, and it's generally well tolerated at usual doses. If you're pregnant, breastfeeding, or take a 5-HT4 agonist, check with your doctor or pharmacist before starting.

High doses can cause digestive upset, so stick to recommended amounts.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Lysine, straight from the product label.

Brand NutraBio
Barcode (UPC) 649908232818
Net contents 17.6 Ounce(s); 1.1 lb(s); 500 Gram(s)
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 278726
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Lysine by NutraBio, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gram(s)
Maximum serving Sizes:
1 Gram(s)
Servings per container
500
UPC/BARCODE
649908232818
IngredientAmount% DV
L-Lysine HCl1 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Mix 1 scoop (1 g) with your favorite beverage 1-2 times daily, as needed.

Formulation

Vegetarian

Gluten free Non-GMO Lactose free

Full label disclosure No proprietary blends Full transparency

Wellness

Precautions

Warning: Keep out of reach of children. This product is not intended/recommended for children under 18 years of age.

Consult a physician before use if you are pregnant, nursing, have a medical condition or are taking any medication.

Discontinue use two weeks prior to surgery.

Processed in a facility and/or manufacturing line that also produces milk, tree nuts and nuts.

Warning: Consuming this product can expose you to chemical including lead, which are known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food.

Seals/Symbols

Check. Verify. Trust. View independent lab results checkmysupps.com

Manufactured in our GMP & FDA inspected facility

Made in USA With ingredients sourced worldwide

OU (Kosher)

Brand IP Statement(s)

NutraBio Since 1996

Formula

Free form amino acid

OU (Kosher)

FDA Statement of Identity

Amino Acid Supplement

General Statements

Product filled to this level

This product is sold by weight not volume. Some settling of contents may have occurred. Serving scoop included.

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Lysine by NutraBio label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Lysine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Lysine by NutraBio

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Gram(s) Dosage formPowder Servings per container500 Amounts shown are per serving.

L-Lysine HCl

Interacts with
1 drug
1 Gram(s) per serving

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...

L-Lysine HCl monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Lysine by NutraBio Drug Interactions

Want to check YOUR meds against L-Lysine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Minor

Ingredients driving the most interactions

L-Lysine HCl 1

Individual Drug Interactions

The ingredients in L-Lysine interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in L-Lysine interact with drugs. Each result below shows which ingredient is responsible. L-Lysine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Lysine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Lysine HCl1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L-Lysine, from the product label.

NutraBio

See all NutraBio products
Name
NutraBio Labs, Inc.
Street Address
564 Lincoln Blvd.
City
Middlesex
State
NJ
ZipCode
08846
Phone Number
732-748-8606
Web Address
www.nutrabio.com
Pharmacist Counseling Corner

L-Lysine by NutraBio: Common Questions

Does L-Lysine by NutraBio interact with any medications?
Yes. Based on its ingredients, L-Lysine has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Lysine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help prevent or shorten a cold sore?
L-lysine is possibly effective for cold sores (herpes labialis). The evidence supports that it may help, though results vary and it's not a guaranteed cure. Many people use it during an outbreak or as a preventative, but talk with your doctor about whether it makes sense for you.
Can I take this if I'm pregnant or breastfeeding?
Supplement safety in pregnancy and breastfeeding hasn't been well studied — lysine from food is fine, but supplement doses are different. There isn't enough data to know either way, so talk with your doctor before using this supplement if you're pregnant or breastfeeding.
What side effects might I experience?
At typical doses, L-lysine is generally well tolerated. High amounts may cause stomach upset, abdominal pain, diarrhea, or indigestion. There's one rare case report linking oral lysine to kidney inflammation, but this is not common.
Is L-lysine the only ingredient in this product?
Yes. NutraBio's L-Lysine powder contains L-lysine HCl as the active ingredient and no other active ingredients or fillers.
Does this work for wound healing or diabetic ulcers?
There isn't enough reliable evidence yet to say whether L-lysine helps with pressure ulcers or diabetic foot ulcers. If wound healing is your concern, talk with your doctor about what's proven for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Lysine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Lysine label
Go deeper

The Full Monographs Behind L-Lysine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph →
Sources

Sources & How We Checked

L-Lysine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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