L-Lysine 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Lysine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Lysine 500 mg is a dietary supplement by Natural Nutra with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Lysine 500 mg by Natural Nutra
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine 500 mg by Natural Nutra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Lysine 500 mg by Natural Nutra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains a single active ingredient: L-lysine at 500 mg per capsule. Lysine is an amino acid — one of the building blocks your body uses to make protein.
The capsule itself and the added inactive ingredients (magnesium stearate and cellulose) are fillers and binders that hold the supplement together.
Does it work?
Moderate evidence
L-lysine is possibly effective for cold sores (herpes labialis) — the research supports its use for that purpose. For other uses listed here, like child growth, pressure ulcers, and diabetic foot ulcers, there isn't enough reliable evidence to say whether it works.
If you're considering lysine for something beyond cold sores, talk it over with your doctor to see if the evidence backs it for your situation.
How safe is it?
Well-documented data
L-lysine is generally well tolerated at typical doses. The most common side effects reported are stomach upset — specifically abdominal pain, diarrhea, and indigestion — though these are not universal.
High doses may increase the risk of stomach problems, and long-term safety at higher amounts hasn't been well studied. There's one rare case report of kidney inflammation linked to oral lysine, though this is not common.
For pregnancy, the safety data on lysine supplements hasn't been well studied, so you'll want to check with your doctor first — lysine from food is fine, but supplements are a different story. On breastfeeding, there isn't enough reliable information, so caution is advised; talk with your doctor or pharmacist for personalized guidance.
Meds to double-check
Minor interactions only
If you take 5-HT4 agonists — medications sometimes used for certain digestive or GI problems — check with your doctor or pharmacist before adding this product, as lysine may reduce how well they work. No other medication types show documented interactions in our data for this ingredient.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
L-lysine may help with cold sores and is generally well tolerated, though some people experience stomach upset. If you take medications for digestive issues (particularly 5-HT4 agonists), check with your doctor or pharmacist before starting.
Pregnant or breastfeeding? Talk it through with your healthcare provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Lysine 500 mg, straight from the product label.
| Brand | Natural Nutra |
|---|---|
| Net contents | 50 Vegan Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 22, 2021 |
| DSLD ID | 246979 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Lysine 500 mg by Natural Nutra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Lysine | 500 mg | -- |
Other ingredients: Capsule, Magnesium Stearate, Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Contains no artificial colors, flavors or preservatives; no wheat, gluten, milk, eggs, peanuts, tree nuts, soy, crustacean shellfish or fish.
Suitable for vegans.
Amino acids are needed by the body to rebuild and repair tissues and muscles, as well as to assist in making enzymes, proteins, and antibodies. L-Lysine is one of the eight essential amino acids that cannot be manufactured by the body. Not only is it needed to support proper growth and bone development, but L-Lysine also improves calcium absorption and helps maintain nitrogen balance in the body.
SGS verified the process of manufacturing this product with no GMO ingredients. www.sgs.com/no-gmo
Purity + potency guaranteed
Free form Supports immune function and tissue growth
Vegan
Non GMO Gluten free
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: Take one capsule daily with food.
Precautions
Keep out of reach of children.
General Statements
To report a serious adverse event, call 1-888-710-0006
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Lysine 500 mg by Natural Nutra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Lysine 500 mg by Natural Nutra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.
L-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: Capsule, Magnesium Stearate, Cellulose. These complete the product’s ingredient list but are not active constituents.
L-Lysine 500 mg by Natural Nutra Drug Interactions
HelloPharmacist Interaction Report
L-Lysine 500 mg by Natural Nutra has documented interactions through its lysine content, though they're limited.
The main concern is with 5-HT4 agonists (a class of medications used for certain digestive issues), where lysine may theoretically reduce how well these drugs work. Animal research suggests lysine acts as a partial blocker of the serotonin receptor 4 that these medications target.
Read the full breakdown — every affected drug type, severity by severity
Additionally, no other medication types show documented interactions with lysine in our data. Altogether, these interactions span 1 individual medication.
To be sure about your specific prescriptions, use the interaction checker on this page or run them by your doctor or pharmacist before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Lysine 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Lysine 500 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Lysine 500 mg interact with drugs. Each result below shows which ingredient is responsible. L-Lysine
TegaserodZelnorm
How Tegaserod interacts with L-Lysine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full L-lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Lysine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for L-Lysine 500 mg, from the product label.
Natural Nutra
See all Natural Nutra products- Name
- Hurd Dynamics LLC, DBA Natural Nutra
- City
- Tampa
- State
- FL
- ZipCode
- 33615
- Phone Number
- 1-888-710-0006
- Web Address
- www.natnutra.com
L-Lysine 500 mg by Natural Nutra: Common Questions
Does L-Lysine 500 mg by Natural Nutra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will L-lysine actually help my cold sores?
What side effects should I watch for?
Is it safe to take while pregnant?
Can I take this while breastfeeding?
What's L-lysine, and what does it do in my body?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Lysine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Lysine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Lysine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC