L-Methionine 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Methionine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Methionine 500 mg is a dietary supplement by Best Naturals with 1 active ingredient. Its ingredients are commonly taken for acetaminophen (tylenol) overdose support, liver health, urinary tract acidification.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of L-Methionine 500 mg by Best Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-methionine, an amino acid your body uses to make proteins and other compounds. L-methionine is also found naturally in protein-rich foods like meat, fish, eggs, and dairy.
Each capsule delivers 500 mg of this amino acid. The inactive ingredients—cellulose, silica, and stearate—are standard capsule fillers and binders.
Does it work?
Couldn't assess
L-methionine is possibly effective for reducing the risk of neural tube birth defects (like spina bifida) when taken during pregnancy. For acetaminophen poisoning, hay fever, asthma, and colorectal cancer, the evidence we hold is insufficient to say whether it works or doesn't — the research isn't settled enough yet to rate it either way.
How safe is it?
Well-documented data
Methionine from food is well tolerated by most people. Supplement doses are a different story.
High-dose supplements may cause dizziness, drowsiness, headache, irritability, vomiting, or low blood pressure, and should only be used under medical guidance. Very high doses (75–100 mg/kg daily) may raise homocysteine levels in the blood, a risk factor for blood vessel disease, though not everyone responds the same way.
Rare serious effects like brain swelling (cerebral edema) have been reported, mostly with intravenous use. During pregnancy, food amounts of methionine are fine, but safety of supplement doses hasn't been proven.
While breastfeeding, dietary amounts are expected to be safe, but supplement safety isn't well studied. Talk with your doctor or pharmacist about whether this dose is right for you if you're pregnant, planning pregnancy, or breastfeeding.
Meds to double-check
No known interactions
No interactions are documented for L-methionine in our data. Because it's a single amino acid with no known drug interactions, you won't need to avoid any specific medication types.
Still, mention it to your doctor or pharmacist before you start, as they may want to monitor you for side effects like dizziness or low blood pressure, especially if you take blood pressure medication.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.
L-methionine may be worth considering if you're interested in the amino acid for neural tube defect prevention during pregnancy — but check with your doctor first, since supplement doses in pregnancy haven't been fully studied. If you're taking it for any other reason, know that the evidence doesn't support those uses yet.
Anyone taking high-dose supplements should do so under medical supervision because of potential side effects like low blood pressure and elevated homocysteine.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Methionine 500 mg, straight from the product label.
| Brand | Best Naturals |
|---|---|
| Barcode (UPC) | 817716015873 |
| Net contents | 120 Vcap(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 269821 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Methionine 500 mg by Best Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Methionine | 1000 mg | -- |
Other ingredients: Cellulose, Silica, Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
L-Methionine is classified as an essential amino acid, which means that it cannot be manufactured by the body. It must be obtained through the diet or by supplementation. The body is able to convert methionine to cysteine which acts as a precursor to the detoxifying antioxidant L-Glutathione. This formulation provides free form L-Methionine to promote optimal absorption and assimilation.
Formulation
Supports detox mechanisms Supports joint health Supports fat metabolism
Premium formula
3rd party lab tested
No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no milk, no corn, no egg, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take two (2) capsules daily as needed, preferably on an empty stomach. Consider taking this product in combination with Best Naturals Choline, Inositol, Lecithin and Milk Thistle.
Precautions
Keep out of the reach of children.
Do not use if safety seal is broken or missing.
Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Storage
Keep in cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to cure, prevent, treat or diagnose any disease.
Seals/Symbols
Made in USA
GMP Good Manufacturing Practice Product
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Methionine 500 mg by Best Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Methionine 500 mg by Best Naturals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Vcap(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
L-Methionine
No knowninteractions
Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...
L-Methionine monograph & interactionsOther (inactive) ingredients: Cellulose, Silica, Stearate. These complete the product’s ingredient list but are not active constituents.
L-Methionine 500 mg by Best Naturals Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in L-Methionine 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for L-Methionine 500 mg, from the product label.
Best Naturals
See all Best Naturals products- Name
- Best Naturals
- Street Address
- PO Box 394
- City
- Kenilworth
- State
- NJ
- ZipCode
- 07033
- Phone Number
- 1-877-659-6004
- Web Address
- www.shopbestnaturals.com
L-Methionine 500 mg by Best Naturals: Common Questions
Does L-Methionine 500 mg by Best Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is L-methionine safe to take while pregnant?
Can I take this while breastfeeding?
What side effects might I experience?
Does L-methionine actually work for what I want to take it for?
What exactly is L-methionine?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Methionine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Methionine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Methionine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Methionine 12 references
- La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
- Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
- Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
- Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
- Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
- McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
- Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
- Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
- Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
- Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
- Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC