D-Mannose Pure Powder Ingredients & Drug Interactions
What is this page for?
First and foremost: checking D-Mannose Pure Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose Pure Powder is a dietary supplement by Best Naturals with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose Pure Powder by Best Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 1 active ingredient: D-mannose, a simple sugar (monosaccharide) that your body doesn't readily use for energy the way it uses glucose. There are no inactive ingredients listed—it's the powder form straight through.
Does it work?
Strong evidence
The evidence on D-mannose is mixed. For carbohydrate-deficient glycoprotein syndrome type 1b (a rare genetic condition affecting how your body makes certain proteins), D-mannose is likely effective as a treatment.
For urinary tract infections (UTIs), the research suggests it's possibly ineffective—meaning studies haven't shown it works well for prevention or treatment of UTIs, despite its popularity for that purpose.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but we don't have high-quality long-term safety data, so extended use should be discussed with your doctor. The most common side effects are bloating, diarrhea, and nausea.
Diarrhea is more likely if you take a single dose larger than 200 mg per kilogram of body weight—high doses can trigger osmotic diarrhea (loose stools from water drawn into the bowel). There isn't enough reliable safety data during pregnancy, so it's best to avoid it unless your doctor advises otherwise.
Safety while breastfeeding hasn't been well studied, so caution is advised—talk with your doctor or pharmacist before using it if you're nursing.
Meds to double-check
No known interactions
No interactions are documented for D-mannose in our data. That said, it's always smart to mention any supplement to your own doctor or pharmacist, especially if you're on medications for blood sugar control or have a condition affecting how your gut absorbs nutrients.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-mannose is worth considering if your doctor has diagnosed you with carbohydrate-deficient glycoprotein syndrome type 1b, where it has solid evidence behind it. If you're thinking about it for UTI prevention, the research doesn't support that use.
Pregnant or breastfeeding? Talk with your doctor or pharmacist first—the safety data just isn't there.
Start with a low dose to see how your stomach handles it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose Pure Powder, straight from the product label.
| Brand | Best Naturals |
|---|---|
| Barcode (UPC) | 817716018287 |
| Net contents | 8 Ounce(s); 227 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 270480 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose Pure Powder by Best Naturals, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
D-Mannose is a monosaccharide hexose sugar, naturally found in some trees, berries and fruits, such as cranberry. Although small amounts of D-Mannose are metabolized by the human body, much of it is rapidly excreted in the urine. In the bladder, D-Mannose can adhere to undesirable foreign substances, preventing them from sticking to the lining of the bladder. Because insubstantial amounts of D-Mannose are used by the body, it does not interfere with blood sugar regulation.
Precautions
Keep out of the reach of children.
Do not use if safety seal is broken or missing.
Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Storage
Keep in cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Bottled in USA
GMP Good Manufacturing Practice Product
Formulation
Premium formula
3rd party lab tested
No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no corn, no soy, no egg, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, mix 1/2 level tablespoon to 8-12 oz water or as directed by your physician.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose Pure Powder by Best Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose Pure Powder by Best Naturals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Gram(s) Dosage formPowder Servings per container113 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
D-Mannose Pure Powder by Best Naturals Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose Pure Powder. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose Pure Powder, from the product label.
Best Naturals
See all Best Naturals products- Name
- Best Naturals
- Street Address
- PO Box 394
- City
- Kenilworth
- State
- NJ
- ZipCode
- 07033
- Phone Number
- 1-877-659-6004
- Web Address
- www.shopbestnaturals.com
D-Mannose Pure Powder by Best Naturals: Common Questions
Does D-Mannose Pure Powder by Best Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-mannose help with my urinary tract infection?
What are the most common side effects?
Is it safe to take long-term?
Can I take this if I'm pregnant?
Is it safe while breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose Pure Powder is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose Pure Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose Pure Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC