L-Arginine L-Ornithine Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Arginine L-Ornithine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Arginine L-Ornithine is a dietary supplement by Best Naturals with 2 active ingredients. Its ingredients are commonly taken for athletic performance and recovery, reducing fatigue, sleep and stress support.Based on those ingredients, 403 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Arginine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Arginine L-Ornithine by Best Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Arginine L-Ornithine by Best Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Arginine L-Ornithine by Best Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients: L-Arginine Hydrochloride and L-Ornithine Hydrochloride. Both are amino acids—building blocks your body uses for various functions.
The tablet also contains several inactive ingredients (excipients) including dicalcium phosphate, microcrystalline cellulose, stearic acid, croscarmellose sodium, magnesium stearate, silicon dioxide, and pharmaceutical glaze, which help form and stabilize the tablet.
Does it work?
Moderate evidence
The evidence for these ingredients is limited. L-Ornithine is possibly effective for athletic performance; for dry skin, insomnia, and gum disease (periodontitis), there isn't enough reliable evidence to rate it.
L-Arginine's effectiveness ratings aren't established in our data. If you're considering this product for a specific condition, talk with your doctor or pharmacist about whether the evidence supports it for your situation.
How safe is it?
Well-documented data
L-Arginine is often well tolerated short-term but can lower blood pressure and isn't safe for everyone without medical guidance. Common side effects when taken by mouth include abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing.
L-Ornithine is generally well tolerated in the short term, though long-term safety hasn't been well studied. During pregnancy, L-Ornithine safety data is too limited—it's best to avoid it; the same applies to breastfeeding.
L-Arginine is rated possibly safe in pregnancy, but lactation safety is not rated. Because of the limited pregnancy and breastfeeding data, discuss this product with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you use blood pressure medications (including ACE inhibitors, ARBs, or other antihypertensives), blood thinners (anticoagulants or antiplatelet drugs), diabetes medications, potassium-sparing diuretics, or sildenafil (Viagra). All of these carry Moderate-severity interaction risks with L-arginine.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product may appeal to people interested in amino acid supplementation, but it carries real risks with common medications, especially blood pressure drugs, blood thinners, diabetes medications, and certain diuretics. If you take any prescription medication, check with your doctor or pharmacist before starting.
Even if you have no medications, L-Arginine can lower blood pressure on its own, so it's not something to self-treat with—mention it to your healthcare provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Arginine L-Ornithine, straight from the product label.
| Brand | Best Naturals |
|---|---|
| Barcode (UPC) | 817716018843 |
| Net contents | 120 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jan 24, 2024 |
| DSLD ID | 306003 |
| Product type | Amino Acid/protein |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Arginine L-Ornithine by Best Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Ornithine Hydrochloride | 250 mg | -- |
| L-Arginine Hydrochloride | 750 mg | -- |
Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, Pharmaceutical Glaze
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Caution: For adults only, if you are pregnant, nursing, taking any medication or have any medical condition, consult your doctor before use.
Caution: For adults only, if you are pregnant, nursing, taking any medication or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of the reach of children.
Do not use if safety seal is broken or missing.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, adults take two (2) tablets twice daily or as directed by a health care professional.
Storage
Keep in cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Made in USA
GMP Good Manufacturing Practice Product
Formulation
Premium formula 3rd party lab tested
No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no milk, no corn, no soy, no egg, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.
Formula
L-Arginine L-Ornithine 1000 mg per serving
FDA Statement of Identity
Dietary Supplement
General Statements
For additional information call 1-877-659-6004
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Arginine L-Ornithine by Best Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Arginine L-Ornithine by Best Naturals
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Ornithine Hydrochloride
No knowninteractions
Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement fo...
L-Ornithine Hydrochloride monograph & interactionsL-Arginine Hydrochloride
Interacts with403 drugs
L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...
L-Arginine Hydrochloride monograph & interactionsOther (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.
L-Arginine L-Ornithine by Best Naturals Drug Interactions
HelloPharmacist Interaction Report
Best Naturals L-Arginine L-Ornithine contains L-arginine, which interacts with several medication classes.
The most serious concern is with blood pressure medications—L-arginine lowers blood pressure by itself, so combining it with antihypertensive drugs, ACE inhibitors, ARBs, or isoproterenol could cause dangerously low blood pressure (hypotension). This is a Moderate-severity risk.
Read the full breakdown — every affected drug type, severity by severity
There are also Moderate-severity interactions with blood thinners (anticoagulants and antiplatelet drugs like warfarin or aspirin)—L-arginine may increase bleeding risk. Additionally, L-arginine may raise potassium levels; combined with potassium-sparing diuretics or ACE inhibitors and ARBs (which also raise potassium), you could develop dangerously high potassium in your blood (hyperkalemia).
Diabetes medications and sildenafil (Viagra) may also have additive effects with L-arginine.
L-Ornithine (the second ingredient) was checked and no interactions are documented in our data. Altogether, these interactions span 403 individual medications.
Use the medication checker below with your exact prescriptions before you start this product. If you take any blood pressure medication, diabetes drug, blood thinner, or diuretic, talk with your doctor or pharmacist first.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Arginine L-Ornithine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Arginine L-Ornithine interact with 403 drugs. Click any drug to see the details.
1 of the 2 ingredients in L-Arginine L-Ornithine interact with drugs. Each result below shows which ingredient is responsible. L-Arginine Hydrochloride
AbciximabReoPro
How Abciximab interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine Hydrochloride + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine Hydrochloride + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine Hydrochloride + Albiglutide interactionAliskirenTekturna
How Aliskiren interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine Hydrochloride + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine Hydrochloride + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine Hydrochloride + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs, Potassium-sparing Diuretics Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs, Potassium-sparing Diuretics Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs, Ace Inhibitors (aceis) Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Ammonium Chloride interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with L-Arginine L-Ornithine — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Anacaulase-bcdb interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Arginine L-Ornithine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Arginine Hydrochloride
Ace Inhibitors (Aceis)
Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.
Angiotensin Receptor Blockers (Arbs)
Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.
Anticoagulant/Antiplatelet Drugs
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.
Antidiabetes Drugs
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.
Antihypertensive Drugs
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.
Isoproterenol (Isuprel)
Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.
Potassium-Sparing Diuretics
Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
Testosterone
Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.
Brand information
Manufacturer and brand details for L-Arginine L-Ornithine, from the product label.
Best Naturals
See all Best Naturals products- Name
- Best Naturals
- Street Address
- PO Box 394
- City
- Kenilworth
- State
- NJ
- ZipCode
- 07033
- Phone Number
- 1-877-659-6004
- Web Address
- www.shopbestnaturals.com
L-Arginine L-Ornithine by Best Naturals: Common Questions
Does L-Arginine L-Ornithine by Best Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What are L-Arginine and L-Ornithine?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I experience?
Does this product actually work?
Is this safe to use with my medications?
Why does the label say to use only under medical supervision?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Arginine L-Ornithine is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Arginine L-Ornithine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Ornithine
Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...
Read the full Ornithine monograph → Herb & supplement monographL-arginine
Interacts with 403 drugsL-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...
Read the full L-arginine monograph →Sources & How We Checked
L-Arginine L-Ornithine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 67 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ornithine 1 reference
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
L-arginine 66 references
- Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
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