Major interaction on record — check this product against your medications before combining. Based on 3 of 7 ingredients. Check your meds →
Dietary supplement

ACG3 Charged+ Orange Ingredients & Drug Interactions

by PMD Platinum

ACG3 Charged+ Orange label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ACG3 Charged+ Orange against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

ACG3 Charged+ Orange is a dietary supplement by PMD Platinum with 7 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,719 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against ACG3 Charged+ Orange by PMD Platinum

Ask about any prescription or over-the-counter medication and we check it for interactions with ACG3 Charged+ Orange by PMD Platinum — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of ACG3 Charged+ Orange by PMD Platinum

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 5 of its 27 active ingredients.
  • “ACG3 Charged+ Blend” is a proprietary blend — the label gives one combined amount (8,796 mg) without saying how much of each component you get.
  • “Magna-3 Complex” is a proprietary blend — the label gives one combined amount (3,000 mg) without saying how much of each component you get.
  • “Nitro-Flow Blend” is a proprietary blend — the label gives one combined amount (2,000 mg) without saying how much of each component you get.

ACG3 Charged+ Orange contains 27 ingredients, 18 of which are active components. The core actives include sodium and calcium (electrolytes and mineral support), amino acids—L-arginine, L-arginine alpha ketoglutarate, L-tyrosine, L-tyrosine-L-tartrate, L-histidine hydrochloride, and taurine—which support muscle function and nitric oxide production.

The product also includes caffeine anhydrous and theobromine (from cocoa) for mental alertness and energy; creatine in three forms (citrate, magnesium chelate, ethyl ester) for muscle strength; beta-alanine (branded CarnoSyn); phosphatidylserine for cognitive support; green tea leaf extract for antioxidant effects; agmatine sulfate for blood flow; and vanadium (bis-picolinato oxo vanadium). Several inactive ingredients—maltodextrin, calcium silicate, natural and artificial flavors, sucralose, citric acid, maize starch, artificial sweeteners, and food colorings—make up the rest.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: High-intensity exercise performance and pre-workout.
  • We looked for evidence on: Athletic performance, Cognitive function, Energy and endurance, Muscle strength, Mental focus.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance, Muscle strength.
  • Also on file: Tyrosine is rated "Possibly Effective" for Cognitive function.

The evidence on this product's ingredients is mixed. Calcium is effective for kidney failure and dyspepsia and likely effective for osteoporosis.

Caffeine is effective for neonatal apnea and postoperative headache, and likely effective for mental alertness and athletic performance. Creatine (in its three forms here) is possibly effective for muscle strength and athletic performance.

Green tea extract is likely effective for human papillomavirus (HPV) prevention and possibly effective for heart health and cholesterol. L-arginine and its forms, taurine, and agmatine all have no established effectiveness ratings in our data—the evidence is insufficient for most of their proposed uses.

L-tyrosine (in both forms) is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory. Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease.

Beta-alanine is possibly effective for athletic performance. Sodium, L-histidine, theobromine, and vanadium also show limited or insufficient evidence for their claimed benefits in this formulation.

The evidence, ingredient by ingredient Sodium Calcium Creatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 17 of the 18 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 18 of 18.
  • General safety write-ups exist for 18 of 18.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients in this product are generally well tolerated in moderate amounts. Calcium and caffeine are safe at recommended doses, though high doses of calcium have rarely been linked to kidney stones and concerns about prostate cancer risk with very high intake (over 1,500–2,000 mg daily).

Caffeine commonly causes anxiety, insomnia, jitteriness, and dependence with regular use. Creatine is generally well tolerated but may cause water retention, muscle cramps, diarrhea, and rarely kidney or muscle injury.

Beta-alanine commonly causes harmless skin tingling (paresthesia) and flushing. Sodium at high levels raises blood pressure and heart strain; normal dietary amounts are fine but avoid supplementing without medical advice.

L-arginine, taurine, tyrosine, and green tea extract are generally well tolerated short-term; L-arginine can lower blood pressure and cause bloating and nausea. Green tea extract has rarely been linked to liver injury at very high doses.

Vanadium at doses above 1.8 mg daily may cause nausea, diarrhea, and rarely kidney damage. Regarding pregnancy and lactation: calcium and taurine are likely safe; caffeine and green tea are possibly safe but advise limiting intake; L-arginine and L-tyrosine have insufficient data—talk with your doctor.

Beta-alanine, creatine, phosphatidylserine, agmatine, and vanadium lack safety data in pregnancy and breastfeeding and should be avoided unless your healthcare provider advises otherwise. L-histidine data on pregnancy and lactation is not on file.

Side effects, ingredient by ingredient Sodium Calcium Creatine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 15 of the 18 matched ingredients can interact with medications — Vanadium, Calcium, Indian Gooseberry, Cocoa, L-arginine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,720 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take any of these: HIV medications (dolutegravir, elvitegravir, raltegravir)—calcium can significantly reduce their effectiveness; blood pressure medications (antihypertensives, ACE inhibitors, ARBs), especially with the L-arginine and sodium content; beta-blockers like nadolol (green tea can reduce effectiveness); statins like atorvastatin (green tea reduces levels); blood thinners or antiplatelet drugs (L-arginine, vanadium may increase bleeding risk); thyroid hormone or levodopa for Parkinson's (tyrosine can interfere); diabetes drugs (L-arginine and vanadium can lower blood sugar); seizure medications (caffeine and green tea may reduce effectiveness); and heart medications like sotalol, diltiazem, or dipyridamole. If you take ephedrine, alert your doctor—the caffeine and green tea in this product carry Major risk of serious stimulant effects.

No interactions are documented for L-norvaline, the blends, or glycerol-silica; we could not check those.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient performance and energy product aimed at athletes and active adults. If you take any prescription medications—especially blood pressure drugs, blood thinners, HIV medications, thyroid hormone, seizure medications, diabetes drugs, or heart medications—check with your pharmacist or doctor before starting.

The high sodium and caffeine content may not suit people with high blood pressure or heart conditions. Those with kidney issues should be cautious with creatine.

Talk to your pharmacist about your full medication list and any health conditions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 22 of 27 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ACG3 Charged+ Orange, straight from the product label.

Brand PMD Platinum
Barcode (UPC) 811020908920
Net contents 12.7 oz.; 360 Gram(s)
Market status On market
Date entered into DSLD Apr 25, 2014
DSLD ID 32016
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ACG3 Charged+ Orange by PMD Platinum, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Gram(s)
Maximum serving Sizes:
12 Gram(s)
Servings per container
30
UPC/BARCODE
811020908920
IngredientAmount% DV
Calories10 {Calories}--
Total Carbohydrates3 Gram(s)1%
Sodium10 mg1%
Calcium98 mg10%
L-Arginine0 NP--
Taurine0 NP--
L-Tyrosine0 NP--
L-Histidine Hydrochloride0 NP--
Caffeine Anhydrous0 NP--
Theobromine0 NP--
CarnoSyn0 NP--
L-Norvaline0 NP--
Green Tea (Camellia sinensis) leaf extract0 NP--
Phosphatidyl Serine0 NP--
Agmatine Sulfate0 NP--
ACG3 Charged+ Blend8796 mg--
Magna-3 Complex3000 mg--
Creatine Citrate0 NP--
Creatine Magnesium Chelate0 NP--
Creatine Ethyl Ester0 NP--
Beta Burn Blend2795 mg--
Bis-Picolinato Oxo Vanadium0 NP--
Nitro-Flow Blend2000 mg--
L-Arginine Alpha Ketoglutarate0 NP--
Neuro-Transmit Matrix651 mg--
Glycerol-Silica Powder0 NP--
L-Tyrosine-L-Tartrate0 NP--
G-Force Energy Blend350 mg--
Amla (Phyllanthus emblica)(fruit) Extract0 NP--
Citrus aurantium (fruit) extract0 NP--
Dendrobium nobile extract0 NP--
Guarana (Paullinia cupana) seed extract0 NP--

Other ingredients: Maltodextrin, Calcium Silicate, Natural and Artificial flavors, Sucralose, Citric Acid, Waxy Maize, Acesulfame Potassium, FD&C Yellow 5, FD&C Red 40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Contains caffeine.

Do not consume synephrine or caffeine from other sources, including but not limited to, coffee, tea, soda and other dietary supplements or medications containing phenylephrine or caffeine.

Do not use for more than 8 weeks.

Consult with your physician prior to use if you are taking medication, including but not limited to MAOI inhibitors, antidepressants, aspirin, nonsteroidal anti-inflammatory drugs or products containing phylephrine, ephedrine, pseudoephedrine, or other stimulants.

Consult your physician prior to use if you have a medical condition, including but not limited to, heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high or low blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma. Do not use if you are prone to dehydration or exposed to excessive heat. Do not use if you suffer from the rare genetic disorder, Hyper Beta-Alaninemia. This product contains beta-alanine which may cause a tingling skin sensation in some individuals. Discontinue use 2 weeks prior to surgery or if you experience rapid heart beat, dizziness, severe headache or shortness of breath. Do not use if tamper resistant seal is broken.

CONTAINS SOY.

Do not exceed recommended dose. Do not exceed 2 scoops in any 24 hour period. Exceeding the recommended amounts or not following directions may lead to unwanted effects.

Discard after expiration date.

WARNING: KEEP OUT OF REACH OF CHILDREN.

For use by Healthy Individuals only.

Not for use by those under the age of 18.

Do not exceed recommended dose.

Do not use if you are pregnant or nursing.

Before consuming seek advice from a health care professional if you are unaware of your current health condition.

Formula

Contains caffeine.

Natural and Artificial Flavor

CONTAINS SOY.

General Statements

HIGH VOLTAGE PRE-WORKOUT

60 SERVINGS

Serving Size 1-2 scoops (6 g - 12 g) Servings Per Container 30-60 Servings

ACHIEVE MAXIMUM ANABOLIC RESULTS!

Maximize your muscle performance and peak your power output for greater results in an accelerated period of time.

Contents may settle after shipping.

Moisture and humidity can cause clumping and discoloration.

Seals/Symbols

78 PMD PLATINUM 78(R)

CREATINE MagnaPOWER(R) Creatine Magnesium Chelate

CarnoSyn(R) Carnosine Synthesizer

Az ADVANTRA Z(R)

FITLIFE BRANDS

Like us on f

FDA Statement of Identity

DIETARY SUPPLEMENT

Brand IP Statement(s)

Caution: ACG3(R) CHARGED+ is an extremely intense pre-workout solution that packs a serious punch. Fully loaded with a potent blend of actives, ACG3(R) CHARGED+ works harmoniously to provide extreme anabolic results, trigger more explosive muscle pumps, increase muscle volume and strength, and provide the endurance necessary to maximize your workout. ACG3(R) CHARGED+ also provides some of the most insane workout energy available on the market, taking your workout to that next level of intensity.

Creatine MagnaPower(R) is a registered trademark of Albion Laboratories, Inc. Covered by U.S. Patent 6,114,379.

CarnoSyn(R) is the registered trademark of Natural Alternatives International (NAI). Covered by U.S. Patents 5,965,596, 6,172,098, 6,426,361, and 8,067,381.

Advantra Z(R) is a registered trademark of Nutratech, Inc./Zhishin, LLC licensor of U.S. Patents 6,224,873; 6,316,499; 6,340,481; 6,340,482, Canadian Patent 2,248,854 and E.U. Patent 0885008.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

GLUTEN FREE

General

-2

Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement, mix 1 scoop of ACG3(R) CHARGED+ with 4-6 oz. of cold water 30-45 minutes before workout. Follow this regimen for the first week of use. If necessary, on week two increase to 1 and a half scoops prior to workout. The optimal dose will vary by individual between 1-2 scoops.

Consume a minimum 125 fl. oz. of water per day while taking this product. To be used as part of a physical conditioning program.

Storage

STORE IN A COOL, DRY PLACE AND AVOID EXCESSIVE HEAT.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ACG3 Charged+ Orange by PMD Platinum label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ACG3 Charged+ Orange label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ACG3 Charged+ Orange by PMD Platinum

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
10 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Calcium

Interacts with
168 drugs
98 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

ACG3 Charged+ Blend

8796 mg per serving
  • › Magna-3 Complex
  • › Beta Burn Blend
  • › Nitro-Flow Blend
  • › Neuro-Transmit Matrix
  • › G-Force Energy Blend

Other (inactive) ingredients: Maltodextrin, Calcium Silicate, Natural and Artificial flavors, Sucralose, Citric Acid, Waxy Maize, Acesulfame Potassium, FD&C Yellow 5, FD&C Red 40. These complete the product’s ingredient list but are not active constituents.

Interaction report

ACG3 Charged+ Orange by PMD Platinum Drug Interactions

Want to check YOUR meds against ACG3 Charged+ Orange?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,719Drugs
30 Major 1,676 Moderate 13 Minor

Ingredients driving the most interactions

Sodium 205
Calcium 168

Individual Drug Interactions

The ingredients in ACG3 Charged+ Orange interact with 1,719 drugs. Click any drug to see the details.

2 of the 7 ingredients in ACG3 Charged+ Orange interact with drugs. Each result below shows which ingredient is responsible. Sodium Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in ACG3 Charged+ Orange with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ACG3 Charged+ Orange, from the product label.

PMD Platinum

See all PMD Platinum products
Name
FitLife Brands, Inc.
Street Address
4509 South 143rd Street, Suite 1
City
Omaha
State
NE
ZipCode
68137
Pharmacist Counseling Corner

ACG3 Charged+ Orange by PMD Platinum: Common Questions

Does ACG3 Charged+ Orange by PMD Platinum interact with any medications?
Yes. Based on its ingredients, ACG3 Charged+ Orange has a known interaction with 1,719 medications, including 30 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ACG3 Charged+ Orange contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
It depends on the ingredient. Calcium and taurine are likely safe in pregnancy; caffeine and green tea are possibly safe but keep intake moderate. Creatine, beta-alanine, phosphatidylserine, agmatine, and vanadium lack enough safety data—avoid them unless your doctor says otherwise. Talk with your doctor or pharmacist about your individual situation before using this product.
What does the caffeine and theobromine do in this product?
Both are stimulants that boost mental alertness and physical energy. Caffeine is likely effective for mental alertness and athletic performance; theobromine (from cocoa) works similarly. Together they can increase heart rate and focus, but they also raise the risk of anxiety, insomnia, and jitteriness—especially at higher doses.
Why is there so much sodium in this?
Sodium is included as an electrolyte to help with hydration and muscle function during intense exercise. But this product is high in sodium, which can raise blood pressure, especially in people with hypertension or salt sensitivity. If you have high blood pressure or heart disease, ask your pharmacist whether the sodium level is safe for you.
Does the creatine in here actually build muscle?
Creatine is possibly effective for muscle strength and athletic performance, particularly when combined with resistance training. It works by boosting energy in muscle cells. However, it commonly causes water retention and may increase weight on the scale—not all of it is muscle. It also requires consistent use over weeks to see benefits.
What is L-arginine supposed to do?
L-arginine boosts nitric oxide, which causes blood vessels to relax and dilate. This improves blood flow and can lower blood pressure. The product includes two forms—straight L-arginine and L-arginine alpha ketoglutarate. However, we don't have established effectiveness data for these specific uses in our files, and it can interact significantly with blood pressure and heart medications.
Will this help with energy and mental focus?
It contains ingredients aimed at both. Caffeine and theobromine are likely effective for mental alertness; tyrosine is possibly effective for cognitive function and memory. L-arginine and other amino acids support blood flow, which may help oxygen delivery to the brain. Results vary by person, and no guarantee is made. Talk to your pharmacist if you're considering it for a specific goal.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ACG3 Charged+ Orange label
Go deeper

The Full Monographs Behind ACG3 Charged+ Orange’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph →
Sources

Sources & How We Checked

ACG3 Charged+ Orange's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1,064 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
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  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
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  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
  34. Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Calcium 62 references
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See these in context on the Calcium monograph →

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
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  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
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  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
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  14. Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
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  16. de Gouw, H. W., Verbruggen, M. B., Twiss, I. M., and Sterk, P. J. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999;54(11):1033-1035. PubMed
  17. Komers, R., Komersova, K., Kazdova, L., Ruzickova, J., and Pelikanova, T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-59. PubMed
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  21. Stokes, G. S., Barin, E. S., Gilfillan, K. L., and Kaesemeyer, W. H. Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave. Am J Hypertens. 2003;16(9 Pt 1):719-724.
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  23. Palloshi, A., Fragasso, G., Piatti, P., Monti, L. D., Setola, E., Valsecchi, G., Galluccio, E., Chierchia, S. L., and Margonato, A. Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension,
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See these in context on the Caffeine monograph →

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See these in context on the Bitter Orange monograph →

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See these in context on the Dendrobium monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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