L-Methionine 500 mg Ingredients & Drug Interactions
by Solgar
What is this page for?
First and foremost: checking L-Methionine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Methionine 500 mg is a dietary supplement by Solgar with 1 active ingredient. Its ingredients are commonly taken for acetaminophen (tylenol) overdose support, liver health, urinary tract acidification.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of L-Methionine 500 mg by Solgar
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-Methionine, an amino acid your body uses for protein synthesis, cell repair, and various metabolic processes. The capsule also holds a few inactive ingredients — vegetable cellulose (the capsule material), silica, and vegetable magnesium stearate — which help hold everything together and keep the powder from clumping.
Does it work?
Moderate evidence
The evidence we hold shows L-Methionine is possibly effective for reducing the risk of neural tube birth defects (a type of brain and spinal cord defect). For acetaminophen poisoning, hay fever, asthma, and colorectal cancer, the evidence isn't strong enough to rate whether it works — there's insufficient reliable data in our files.
How safe is it?
Well-documented data
L-Methionine from food is well tolerated. At supplement doses, though, you should use it with medical guidance.
The most common side effects reported are dizziness, drowsiness, low blood pressure (hypotension), irritability, vomiting, headache, and increased urinary calcium loss. Rare serious effects include brain swelling and liver-related encephalopathy.
High-dose methionine (75–100 mg per kilogram of body weight daily) may raise homocysteine levels, a risk factor for vascular disease, though one study in people with type 2 diabetes and heart disease history didn't see this effect. For pregnancy and breastfeeding, the safety data we hold rates L-Methionine as likely safe.
That said, supplement doses during pregnancy and breastfeeding haven't been thoroughly studied — food amounts are expected to be fine, but there isn't enough data on higher-dose supplements. Talk with your doctor or pharmacist before taking this if you're pregnant, planning to become pregnant, or breastfeeding.
Meds to double-check
No known interactions
No interactions are documented in our data for L-Methionine. Still, talk with your pharmacist or doctor before you start, especially if you take any prescription medications regularly.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
L-Methionine may be worth considering if you're looking to support neural tube health during pregnancy or if you want general amino acid support — though evidence for most other uses isn't established yet. If you're pregnant or breastfeeding, have liver or kidney concerns, or take any regular medications, check in with your doctor or pharmacist before starting.
High doses should only be used under medical guidance.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Methionine 500 mg, straight from the product label.
| Brand | Solgar |
|---|---|
| Barcode (UPC) | 033984017689 |
| Net contents | 30 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 26, 2020 |
| DSLD ID | 214658 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Methionine 500 mg by Solgar, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Methionine | 500 mg | -- |
Other ingredients: Vegetable Cellulose, Silica, Vegetable Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
L-Methionine is an essential amino acid that acts as an antioxidant. The body is able to convert methionine to cysteine which acts as a precursor to the detoxifying antioxidant L-Glutathione. Methionine is also lipotropic, helping to support fat metabolism. This formulation provides Free Form L-Methionine to promote optimal absorption and assimilation.
Solgar's KOF-K certification #K-1250
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
2009 Solgar, Inc.
General Statements
Solgar since 1947
Formulation
Free form Detoxifying antioxidant
Gluten, wheat & dairy free
Suitable for vegetarians
Free of: Gluten, wheat, dairy, soy, yeast, sugar, sodium, artificial flavor, sweetener, preservatives and color.
Seals/Symbols
K Parve (Kosher)
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement for adults, take one (1) to two (2) vegetable capsules daily, between meals, or as directed by a healthcare practitioner.
Precautions
If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.
Keep out of reach of children.
Do not use if outer bottle seal is missing, torn or damaged in any way.
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Methionine 500 mg by Solgar label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Methionine 500 mg by Solgar
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.
L-Methionine
No knowninteractions
Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...
L-Methionine monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Silica, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
L-Methionine 500 mg by Solgar Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in L-Methionine 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for L-Methionine 500 mg, from the product label.
Solgar
See all Solgar products- Name
- Solgar, Inc.
- Street Address
- 500 Willow Tree Road
- City
- Leonia
- State
- NJ
- ZipCode
- 07605
- Phone Number
- 1-877-765-4274
- Web Address
- www.solgar.com
L-Methionine 500 mg by Solgar: Common Questions
Does L-Methionine 500 mg by Solgar interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is L-Methionine safe to take while pregnant?
What side effects might I notice?
Will this help with asthma or hay fever?
Is this safe to take with my medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Methionine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Methionine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Methionine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Methionine 12 references
- La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
- Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
- Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
- Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
- Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
- McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
- Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
- Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
- Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
- Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
- Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC