Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Horse Chestnut Seed Extract Ingredients & Drug Interactions

by Solgar

Horse Chestnut Seed Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Horse Chestnut Seed Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Horse Chestnut Seed Extract is a dietary supplement by Solgar with 2 active ingredients. Its ingredients are commonly taken for chronic venous insufficiency, leg swelling and heaviness, varicose veins.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are standardized Horse Chestnut extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Horse Chestnut Seed Extract by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with Horse Chestnut Seed Extract by Solgar — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Horse Chestnut Seed Extract by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: a standardized horse chestnut seed extract (from which the toxic compound esculin has been removed) and raw horse chestnut powder. Both are meant to support circulation and leg health.

The capsule also holds several inactive ingredients — vegetable cellulose, microcrystalline cellulose, vegetable magnesium stearate, and a PhytO2X Blend — which are fillers and binders that help hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Horse Chestnut's overall clinical evidence instead.

Moderate

Some clinical evidence supports Horse Chestnut for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Chronic venous insufficiency (CVI) — rated "Possibly Effective" (Natural Medicines).

Horse chestnut seed extract is possibly effective for chronic venous insufficiency (CVI) — the pooling of blood in leg veins that causes swelling and discomfort. The evidence we hold isn't strong enough yet to rate it for hemorrhoids, irritable bowel syndrome, or kidney stones, even though some people use it for those purposes.

The evidence, ingredient by ingredient Horse Chestnut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The properly processed extract in this product is generally well tolerated. The most common side effects from the extract are dizziness, upset stomach, headache, and itching.

However, this product also contains raw horse chestnut powder, which is toxic and carries a risk of severe gastrointestinal irritation and kidney damage — that's a significant safety difference from the extract alone. Do not use this product during pregnancy or while breastfeeding; there isn't enough safety data, and the safety data we hold advises against it.

One case report described a serious heart condition in someone who consumed large amounts of horse chestnut paste over weeks, possibly tied to the plant's antiplatelet activity.

Side effects, ingredient by ingredient Horse Chestnut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Horse Chestnut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs — aspirin, warfarin, clopidogrel, and others in that category. Horse chestnut may increase your bleeding risk with these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with leg swelling from chronic venous insufficiency, but the mix of a processed extract and raw powder raises safety concerns — especially the raw part's toxicity risk. If you take blood thinners or antiplatelet drugs, you need to check with your doctor or pharmacist before starting.

Pregnant and breastfeeding people should avoid it entirely.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Horse Chestnut Seed Extract, straight from the product label.

Brand Solgar
Barcode (UPC) 033984041271
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 216723
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Horse Chestnut Seed Extract by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetable Capsule(s)
Maximum serving Sizes:
1 Vegetable Capsule(s)
UPC/BARCODE
033984041271
IngredientAmount% DV
standardized Horse Chestnut extract250 mg--
raw Horse Chestnut powder100 mg--

Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate, PhytO2X Blend

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Solgar's Standardized Full Potency (SFP) Herbs are developed through a unique process that integrates the ideologies of both traditional herbalism and standardized herbal technology. To ensure consistent and reliable phytonutrient levels, we isolate a controlled amount of these important active plant compounds. Then, we blend these enhanced, "standardized" compounds with all of the components that occur naturally in the whole raw herb. The result is a potent, premium-quality standardized herbal extract with all of the synergistic and beneficial qualities found in nature.

Solgar's Horse Chestnut Seed Extract Vegetable Capsules are free of sugar, salt, corn, yeast, wheat, soy, gluten, dairy and animal products and are formulated without the use of artificial preservatives, flavors or colors.

Standardized Full potency

Suitable for vegetarians

Storage

To assure freshness and potency, store at room temperature 59 degrees-86 degrees F (15 degrees-30 degrees C). Store away from heat, light and moisture.

Precautions

Do not use if outer bottle seal is missing, torn or damaged in any way.

If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

Brand IP Statement(s)

PHYTOX2 SYSTEM

PhytO2X is a special blend of antioxidants, the purpose of which is to maintain the freshness of the ingredients.

General Statements

Solgar since 1947

Formula

(Aesculus hippocastanum)

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As an herbal dietary supplement for adults, take one (1) vegetable capsule up to two (2) times daily, preferably at mealtime, or as directed by a healthcare practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Horse Chestnut Seed Extract by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Horse Chestnut Seed Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Horse Chestnut Seed Extract by Solgar

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetable Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Standardized Horse Chestnut extract

Interacts with
122 drugs
250 mg per serving Form: Aescin

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and h...

Standardized Horse Chestnut extract monograph & interactions

Raw Horse Chestnut powder

Interacts with
122 drugs
100 mg per serving

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and h...

Raw Horse Chestnut powder monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate, PhytO2X Blend. These complete the product’s ingredient list but are not active constituents.

Interaction report

Horse Chestnut Seed Extract by Solgar Drug Interactions

Want to check YOUR meds against Horse Chestnut Seed Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

standardized Horse Chestnut extract 122

Individual Drug Interactions

The ingredients in Horse Chestnut Seed Extract interact with 122 drugs. Click any drug to see the details.

1 of the 2 ingredients in Horse Chestnut Seed Extract interact with drugs. Each result below shows which ingredient is responsible. standardized Horse Chestnut extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Horse Chestnut Seed Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

standardized Horse Chestnut extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Horse chestnut contains the constituent esculin which has been shown to have antithrombotic effects. Therefore, horse chestnut might have antiplatelet effects. This has not been shown in humans.

Likelihood Possible Evidence D
standardized Horse Chestnut extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Horse Chestnut Seed Extract, from the product label.

Solgar

See all Solgar products
Name
Solgar Vitamin and Herb
City
Leonia
State
N.J.
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

Horse Chestnut Seed Extract by Solgar: Common Questions

Does Horse Chestnut Seed Extract by Solgar interact with any medications?
Yes. Based on its ingredients, Horse Chestnut Seed Extract has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Horse Chestnut Seed Extract contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is horse chestnut supposed to do?
Horse chestnut seed extract is possibly effective for chronic venous insufficiency — that's the swelling and discomfort that happens when blood pools in your leg veins. Some people use it for hemorrhoids and other digestive issues, but the evidence for those uses isn't established yet.
Is the raw horse chestnut powder in this product safe?
Raw horse chestnut is toxic — that's why most supplements use only the processed extract, where the toxic compound has been removed. This product has both, which means you're getting the riskier raw form alongside the safer extract. That's worth discussing with your pharmacist.
What are the side effects I might notice?
From the processed extract, the most common ones are dizziness, upset stomach, headache, and itching. The raw powder carries a higher risk of stomach irritation and kidney damage. One person also reported leg cramps while taking horse chestnut for leg swelling.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against it during both pregnancy and breastfeeding because there isn't enough information to know it's safe.
Why does this product have both an extract and raw powder?
The product facts don't explain the reason. That's a good question to ask the manufacturer or your pharmacist — they may be able to tell you more about the formula's design.
How do I know if this will interact with my medications?
Use the interaction checker on this page to search your exact medications. If you take any blood thinners or antiplatelet drugs, definitely check with your doctor or pharmacist before starting — that's the main interaction risk with horse chestnut.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Horse Chestnut Seed Extract label
Go deeper

The Full Monographs Behind Horse Chestnut Seed Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horse Chestnut

Interacts with 122 drugs

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and heaviness. Raw, unprocessed horse chestnu...

Read the full Horse Chestnut monograph →
Sources

Sources & How We Checked

Horse Chestnut Seed Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horse Chestnut 21 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Greeske K, Pohlmann BK. Horse chestnut seed extract-an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency. Fortschr Med 1996;114:196-200.
  6. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  7. Takegoshi K, Tohyama T, Okuda K, et al. A case of Venoplant-induced hepatic injury. Gastroenterol Jpn 1986;21:62-5.
  8. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
  9. Popp W, Horak F, Jager S, et al. Horse chestnut (Aesculus hippocastanum) pollen: a frequent cause of allergic sensitization in urban children. Allergy 1992;47:380-3.
  10. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  11. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103:507-13. PubMed
  12. Comaish JS, Kersey PJ. Contact dermatitis to extract of horse chestnut (esculin). Contact Dermatitis 1980;6:150-1. PubMed
  13. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd. PubMed
  14. Ottillinger, B. and Greeske, K. Rational therapy of chronic venous insufficiency--chances and limits of the therapeutic use of horse-chestnut seeds extract. BMC.Cardiovasc.Disord. 2001;1(1):5. PubMed
  15. Pittler, M. H. and Ernst, E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane.Database.Syst.Rev. 2004;(2):CD003230. PubMed
  16. Fang, Y., Zhao, L., Yan, F., Xia, X., Xu, D., and Cui, X. Escin improves sperm quality in male patients with varicocele-associated infertility. Phytomedicine. 2010;17(3-4):192-196. PubMed
  17. De Smet, P. A., Van den Eertwegh, A. J., Lesterhuis, W., and Stricker, B. H. Hepatotoxicity associated with herbal tablets. BMJ 7-13-1996;313(7049):92.
  18. Rehn, D., Unkauf, M., Klein, P., Jost, V., and Lucker, P. W. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. Arzneimittelforschung 1996;46(5):483-487.
  19. Edem E, Kahyaoglu B, Çakar MA. Acute Effusive Pericarditis due to Horse Chestnut Consumption. Am J Case Rep. 2016;17:305-8. PubMed
  20. Costa Santos D, Lérias G, Madruga I. Drug-induced Liver Injury Due to a Horse Chestnut Dietary Supplement. Eur J Case Rep Intern Med 2021;8(3):002389. PubMed
  21. Yi HY, Lee JY. Poisoning due to consumption of horse chestnut seed. Clin Exp Emerg Med 2021;8(4):333-335. PubMed

See these in context on the Horse Chestnut monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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