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Dietary supplement

Venastat Horse Chestnut Extract Ingredients & Drug Interactions

by AJG Brands

Venastat Horse Chestnut Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Venastat Horse Chestnut Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Venastat Horse Chestnut Extract is a dietary supplement by AJG Brands with 1 active ingredient. Its ingredients are commonly taken for chronic venous insufficiency, leg swelling and heaviness, varicose veins.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horse Chestnut HC167(R) Extract Seed. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Venastat Horse Chestnut Extract by AJG Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with Venastat Horse Chestnut Extract by AJG Brands — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Venastat Horse Chestnut Extract by AJG Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Venastat contains one active ingredient: Horse Chestnut HC167(R) Extract Seed. This is a processed extract of horse chestnut seed that has been treated to remove esculin, a toxic compound found in raw plant material.

The supplement also contains several inactive ingredients — gelatin, dextrin, talc, copolyvidone, food glaze, polymethacrylic acid derivatives, titanium dioxide, and synthetic iron oxides — which serve as capsule material, binders, and colorants.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: leg health and chronic venous insufficiency.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Postoperative swelling, varicose veins, leg swelling, venous edema.
  • The strongest evidence on file: Horse Chestnut is rated "Possibly Effective" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Horse Chestnut is rated "Insufficient Reliable Evidence To Rate" for Postoperative swelling.

Horse chestnut extract is possibly effective for chronic venous insufficiency (CVI) — a condition where leg veins have trouble returning blood to the heart. The evidence supporting its use for other conditions we hold data on — hemorrhoids, irritable bowel syndrome, and kidney stones — is insufficient to rate.

The evidence, ingredient by ingredient Horse Chestnut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When properly processed to remove the toxic compound esculin, horse chestnut extract is generally well tolerated orally. The most common side effects reported in studies are dizziness, gastrointestinal upset, headache, and itching.

Rare but serious events have been reported, including a case of fluid buildup around the heart in one person, and calf spasms in some patients taking the extract for CVI. Do not take Venastat during pregnancy or while breastfeeding — there isn't enough safety information, and the data advises against it.

Also avoid this supplement if you use raw horse chestnut plant material, which is toxic; only the processed seed extract is appropriate for supplement use.

Side effects, ingredient by ingredient Horse Chestnut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Horse Chestnut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Venastat, check with your doctor or pharmacist if you use anticoagulants (blood thinners like warfarin) or antiplatelet drugs (such as aspirin or clopidogrel). Horse chestnut may increase the risk of bleeding when used together with these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Venastat may help with leg swelling and discomfort from chronic venous insufficiency. However, it should not be combined with blood thinners or antiplatelet drugs without your doctor's or pharmacist's approval, because it may increase bleeding risk.

Talk it over with your own healthcare provider before starting, especially if you take any heart or blood pressure medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 1, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Venastat Horse Chestnut Extract, straight from the product label.

Brand AJG Brands
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 1, 2012
DSLD ID 12902
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Venastat Horse Chestnut Extract by AJG Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Horse Chestnut HC167(R) Extract Seed600 mg--

Other ingredients: Natural organic sugar can extract, Dextrin, Gelatin, Copolyvidone, Talc, Food Glaze, polymethacrylic acid derivatives, Titanium Dioxide, synthetic iron oxides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Take Charge of Your Leg Health Scientific evidence shows that horse chestnut seed extract is effective as reference medications in alleviating the objective signs and subjective symptoms of chronic venous insufficiency. READ MORE Quality Guarantee The Alan James Group is committed to safety, efficacy and providing the highest quality products available. READ MORE

Available in 60 and 105 count size capsules.

Helps Relieve Achy, Tired or Swollen Legs Promotes Leg Circulation Clinically Proven Safe & Effective

Helps Relieve Achy Tired or Swollen Legs

Seals/Symbols

Quality Guarantee

Formula

Natural Leg Vein Health Venastat contains an all-natural standardized horse chestnut seed extract.

Suggested/Recommended/Usage/Directions

Recommended Intake Adults should take one capsule every 12 hours (2 per day 600mg per daily serving). It should be taken swallowed with water before meals. Clinical research has shown effectiveness in as early as four weeks with continuous, daily use.

Brand IP Statement(s)

Venastat's HC167(R) horse chestnut extract is standardized to 16.7% escin to provide a consistent...READ MORE

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Venastat Horse Chestnut Extract by AJG Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Venastat Horse Chestnut Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Venastat Horse Chestnut Extract by AJG Brands

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Horse Chestnut HC167(R) Extract Seed

Interacts with
122 drugs
600 mg per serving Form: Standardized to contain 16.7% Escin

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and h...

Horse Chestnut HC167(R) Extract Seed monograph & interactions

Other (inactive) ingredients: Natural organic sugar can extract, Dextrin, Gelatin, Copolyvidone, Talc, Food Glaze, Polymethacrylic acid derivatives, Titanium Dioxide, Synthetic iron oxides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Venastat Horse Chestnut Extract by AJG Brands Drug Interactions

Want to check YOUR meds against Venastat Horse Chestnut Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Horse Chestnut HC167(R) Extract Seed 122

Individual Drug Interactions

The ingredients in Venastat Horse Chestnut Extract interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Venastat Horse Chestnut Extract interact with drugs. Each result below shows which ingredient is responsible. Horse Chestnut HC167(R) Extract Seed

Each ingredient & the kinds of drugs it affects

For each ingredient in Venastat Horse Chestnut Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Horse Chestnut HC167(R) Extract Seed1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Horse chestnut contains the constituent esculin which has been shown to have antithrombotic effects. Therefore, horse chestnut might have antiplatelet effects. This has not been shown in humans.

Likelihood Possible Evidence D
Horse Chestnut HC167(R) Extract Seed full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Venastat Horse Chestnut Extract, from the product label.

AJG Brands

See all AJG Brands products
Name
AJG Brands, Inc., Alan James Group
Pharmacist Counseling Corner

Venastat Horse Chestnut Extract by AJG Brands: Common Questions

Does Venastat Horse Chestnut Extract by AJG Brands interact with any medications?
Yes. Based on its ingredients, Venastat Horse Chestnut Extract has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Venastat Horse Chestnut Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is chronic venous insufficiency, and does horse chestnut actually help?
Chronic venous insufficiency is a condition where the veins in your legs can't pump blood back to your heart efficiently, causing swelling and discomfort. Horse chestnut extract is possibly effective for this condition based on the evidence we hold, but it's not a cure — talk with your doctor about whether it might help your specific situation.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against it. There isn't enough information to know it's safe during pregnancy or while breastfeeding, so it's best to avoid this supplement at those times.
What are the most common side effects?
Dizziness, stomach upset, headache, and itching are the most common side effects reported. Rare but serious events like heart or muscle problems have also been reported, though they're uncommon.
Is the raw horse chestnut plant safe to use instead of this extract?
No — raw horse chestnut seed or bark is toxic. Only the properly processed extract with the toxic compound removed is suitable for use as a supplement.
Does horse chestnut work for hemorrhoids or other digestive issues?
We don't have enough reliable evidence to rate horse chestnut for hemorrhoids, irritable bowel syndrome, or kidney stones, so we can't say whether it helps those conditions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Venastat Horse Chestnut Extract label
Go deeper

The Full Monographs Behind Venastat Horse Chestnut Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horse Chestnut

Interacts with 122 drugs

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and heaviness. Raw, unprocessed horse chestnu...

Read the full Horse Chestnut monograph →
Sources

Sources & How We Checked

Venastat Horse Chestnut Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horse Chestnut 21 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Greeske K, Pohlmann BK. Horse chestnut seed extract-an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency. Fortschr Med 1996;114:196-200.
  6. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  7. Takegoshi K, Tohyama T, Okuda K, et al. A case of Venoplant-induced hepatic injury. Gastroenterol Jpn 1986;21:62-5.
  8. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
  9. Popp W, Horak F, Jager S, et al. Horse chestnut (Aesculus hippocastanum) pollen: a frequent cause of allergic sensitization in urban children. Allergy 1992;47:380-3.
  10. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  11. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103:507-13. PubMed
  12. Comaish JS, Kersey PJ. Contact dermatitis to extract of horse chestnut (esculin). Contact Dermatitis 1980;6:150-1. PubMed
  13. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd. PubMed
  14. Ottillinger, B. and Greeske, K. Rational therapy of chronic venous insufficiency--chances and limits of the therapeutic use of horse-chestnut seeds extract. BMC.Cardiovasc.Disord. 2001;1(1):5. PubMed
  15. Pittler, M. H. and Ernst, E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane.Database.Syst.Rev. 2004;(2):CD003230. PubMed
  16. Fang, Y., Zhao, L., Yan, F., Xia, X., Xu, D., and Cui, X. Escin improves sperm quality in male patients with varicocele-associated infertility. Phytomedicine. 2010;17(3-4):192-196. PubMed
  17. De Smet, P. A., Van den Eertwegh, A. J., Lesterhuis, W., and Stricker, B. H. Hepatotoxicity associated with herbal tablets. BMJ 7-13-1996;313(7049):92.
  18. Rehn, D., Unkauf, M., Klein, P., Jost, V., and Lucker, P. W. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. Arzneimittelforschung 1996;46(5):483-487.
  19. Edem E, Kahyaoglu B, Çakar MA. Acute Effusive Pericarditis due to Horse Chestnut Consumption. Am J Case Rep. 2016;17:305-8. PubMed
  20. Costa Santos D, Lérias G, Madruga I. Drug-induced Liver Injury Due to a Horse Chestnut Dietary Supplement. Eur J Case Rep Intern Med 2021;8(3):002389. PubMed
  21. Yi HY, Lee JY. Poisoning due to consumption of horse chestnut seed. Clin Exp Emerg Med 2021;8(4):333-335. PubMed

See these in context on the Horse Chestnut monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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