No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Methionine Ingredients & Drug Interactions

by Pure Encapsulations

L-Methionine label
See full label image
Capsule Category: Amino Acid/protein
No known interaction
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Methionine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

L-Methionine is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for acetaminophen (tylenol) overdose support, liver health, urinary tract acidification.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of L-Methionine by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-methionine, an amino acid your body uses to build proteins and perform other essential functions. The capsule itself is made with cellulose and water as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Methionine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Methionine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Neural tube birth defects — rated "Possibly Effective" (Natural Medicines).

L-methionine is rated possibly effective for reducing neural tube birth defects — a serious birth outcome you want to prevent. For acetaminophen poisoning, hay fever, asthma, and colorectal cancer, the evidence we hold is insufficient to rate it.

That means either the research is limited or the results so far aren't conclusive enough to say whether it works for those uses.

The evidence, ingredient by ingredient Methionine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-methionine is generally well tolerated in the amounts you'd eat in food. When taken as a high-dose supplement, though, it should only be used under medical guidance.

The most common side effects in studies were dizziness, drowsiness, low blood pressure (hypotension), irritability, vomiting, and headache. High doses can also raise homocysteine levels in your blood — a marker linked to heart disease — and increase calcium loss in urine.

Rare serious side effects include brain swelling (cerebral edema) and liver-related brain dysfunction (hepatic encephalopathy). For pregnancy and breastfeeding, normal food amounts are fine, but the safety of supplement doses hasn't been proven, so talk with your doctor or pharmacist if you're pregnant or nursing and thinking about taking this product.

Side effects, ingredient by ingredient Methionine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for L-methionine. Still, because high doses can lower blood pressure and raise homocysteine, check with your own doctor or pharmacist before taking this product, especially if you're on blood pressure medication or have cardiovascular concerns.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

L-methionine may be worth considering if you're looking for support with neural tube defect prevention during pregnancy and your healthcare provider recommends it. If you have a history of heart disease, high homocysteine, or take blood pressure medication, talk it over with your doctor or pharmacist first — and check in with them before starting any new supplement.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Methionine, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298001845
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 293998
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Methionine by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
766298001845
IngredientAmount% DV
L-Methionine375 mg--

Other ingredients: Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule, 2-3 times daily, between meals.

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Precautions

Keep out of the reach of children.

Use only if safety seal is intact.

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

Formulation

Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

Liver and tissue support Gluten-free, Non-GMO & hypoallergenic

Gluten-free, Non-GMO & hypoallergenic

Seals/Symbols

GFCO.org (Gluten-Free Certification Organization)

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Methionine by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Methionine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Methionine by Pure Encapsulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

L-Methionine

No known
interactions
375 mg per serving

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...

L-Methionine monograph & interactions

Other (inactive) ingredients: Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Methionine by Pure Encapsulations Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Methionine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Methionine, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

L-Methionine by Pure Encapsulations: Common Questions

Does L-Methionine by Pure Encapsulations interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Methionine. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Methionine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-methionine safe to take while I'm pregnant?
Normal dietary amounts of L-methionine are fine during pregnancy. However, the safety of supplement doses during pregnancy hasn't been proven, so talk with your doctor or pharmacist before starting this product if you're pregnant or planning to become pregnant.
Can I take this while breastfeeding?
Food amounts are expected to be fine, but the safety of supplement doses while breastfeeding hasn't been well studied. Check with your doctor or pharmacist before taking this product if you're nursing.
Does L-methionine actually work for anything?
L-methionine is possibly effective for reducing neural tube birth defects. For acetaminophen poisoning, hay fever, asthma, and colorectal cancer, we don't have enough reliable evidence to say whether it works.
What side effects might I get?
Most common side effects in studies were dizziness, drowsiness, low blood pressure, irritability, vomiting, and headache. High-dose methionine can raise homocysteine levels in your blood and increase calcium loss in urine. Rare serious effects include brain swelling and liver-related brain dysfunction — if you experience severe symptoms, seek medical attention right away.
Why would I take a supplement form if food has methionine in it?
Food amounts are generally safe. Supplement doses are much higher and should be used only under medical guidance — if you're considering a supplement form for a specific health reason, talk with your doctor or pharmacist first about whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Methionine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Methionine label
Go deeper

The Full Monographs Behind L-Methionine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph →
Sources

Sources & How We Checked

L-Methionine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
  3. Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
  4. Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
  6. McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
  7. Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
  8. Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
  9. Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
  10. Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
  11. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
  12. Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed

See these in context on the Methionine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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