L-Methionine Free Form 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Methionine Free Form 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Methionine Free Form 500 mg is a dietary supplement by Vitamin World with 1 active ingredient. Its ingredients are commonly taken for acetaminophen (tylenol) overdose support, liver health, urinary tract acidification.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of L-Methionine Free Form 500 mg by Vitamin World
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This is a single-ingredient supplement: L-methionine, a free-form amino acid, at 500 mg per tablet. L-methionine is an amino acid your body uses to build proteins and to produce other compounds that support joint, skin, and connective tissue health.
The rest of the tablet is inactive ingredients — vegetable cellulose, calcium carbonate, povidone, silica, vegetable magnesium stearate, and stearic acid — that help hold the tablet together and make it easier to swallow.
Does it work?
Moderate evidence
The evidence we have is limited. L-methionine is rated possibly effective for reducing the risk of neural tube birth defects during pregnancy, though more reliable research is needed.
For acetaminophen (Tylenol) poisoning, hay fever, asthma, and colorectal cancer, there isn't enough reliable evidence to say whether it works. If you're considering this supplement for a specific health concern, talk it over with your doctor — they can help you weigh what the evidence shows against your own situation.
How safe is it?
Well-documented data
L-methionine from food is generally well tolerated. At supplement doses, though, side effects are possible: dizziness, drowsiness, headache, low blood pressure, irritability, and vomiting have been reported.
High-dose supplements may also raise homocysteine levels and increase calcium loss in your urine. Serious side effects like brain swelling or liver-related brain problems are rare but have been documented.
Because high-dose supplements carry more risk than dietary amounts, use this only under medical guidance. During pregnancy, food amounts of methionine are expected to be fine, but safety data on supplement doses during pregnancy is lacking — talk with your doctor before taking this if you're pregnant.
Similarly, breastfeeding safety of supplement doses hasn't been well studied; check with your pharmacist or doctor first.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we checked. That doesn't guarantee none exist — it means we have no data showing them.
Before taking this supplement, check your exact medications with the search tool on this page, or ask your pharmacist to review your full list to be sure.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
L-Methionine is a single amino acid supplement that's generally well tolerated at food amounts but carries more risk at supplement doses. It may be worth considering if you're pregnant and concerned about neural tube defects, but the evidence for other uses is too thin to rely on right now.
Before you start, especially if you have heart or blood vessel disease, or if you're pregnant or breastfeeding, talk it over with your doctor or pharmacist — they know your full health picture and can tell you whether this is right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Methionine Free Form 500 mg, straight from the product label.
| Brand | Vitamin World |
|---|---|
| Barcode (UPC) | 074312701405 |
| Net contents | 50 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Oct 26, 2011 |
| DSLD ID | 1151 |
| Product type | Amino Acid/protein |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Methionine Free Form 500 mg by Vitamin World, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Methionine | 500 mg | -- |
Other ingredients: Vegetable Cellulose, Calcium Carbonate, Povidone, Silica, Vegetable Magnesium Stearate, Stearic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
(C) 2010 Vitamin World, Inc.
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.
VEGETARIAN AMINO ACID SUPPLEMENT
Precautions
WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Keep out of reach of children. Store in a cool, dry place. Do not use if seal under cap is broken or missing.
General Statements
Amino Acids provide the crucial building blocks for protein.* Protein plays a role in constructing and maintaining the critical structures and functions of the body. L-Methionine is one of the nine essential Amino Acids necessary for balanced nutrition and good health.*
From the moment raw ingredients reach our facilities to the time a finished supplement is packaged, stringent analysis confirms the potency, purity and nutritional content of every nutritional product that bears the Vitamin World name. We guarantee it!
Lipotropic Agent Promotes Protein Metabolism*
Get healthy.
General
PROD. #140 B140 05C
Seals/Symbols
QUALITY ASSURED
Suggested/Recommended/Usage/Directions
DIRECTIONS: For adults, take one (1) to two (2) tablets daily, preferably on an empty stomach.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Methionine Free Form 500 mg by Vitamin World label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Methionine Free Form 500 mg by Vitamin World
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
L-Methionine
No knowninteractions
Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...
L-Methionine monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Calcium Carbonate, Povidone, Silica, Vegetable Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.
L-Methionine Free Form 500 mg by Vitamin World Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in L-Methionine Free Form 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for L-Methionine Free Form 500 mg, from the product label.
Vitamin World
See all Vitamin World products- Phone Number
- 1-800-228-4533
- Web Address
- www.vitaminworld.com
L-Methionine Free Form 500 mg by Vitamin World: Common Questions
Does L-Methionine Free Form 500 mg by Vitamin World interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to take if I'm pregnant?
Is it safe while breastfeeding?
What are the most common side effects?
Can methionine raise my homocysteine levels?
Does this work for acetaminophen poisoning?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Methionine Free Form 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Methionine Free Form 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Methionine Free Form 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Methionine 12 references
- La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
- Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
- Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
- Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
- Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
- McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
- Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
- Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
- Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
- Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
- Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC