L-Methylfolate 1 mg Ingredients & Drug Interactions
by MethylPro
What is this page for?
First and foremost: checking L-Methylfolate 1 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Methylfolate 1 mg is a dietary supplement by MethylPro with 2 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Methylfolate 1 mg by MethylPro
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Methylfolate 1 mg by MethylPro — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Methylfolate 1 mg by MethylPro
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This capsule contains two active ingredients: glycine and folate (in L-methylfolate form, a type of B vitamin). The product also includes cellulose as an inactive ingredient.
Glycine is an amino acid, and folate is a B vitamin your body uses for cell division and DNA synthesis.
Does it work?
Moderate evidence
Glycine is rated possibly effective for schizophrenia based on available evidence. For other uses listed in the product facts—3-phosphoglycerate dehydrogenase deficiency, ADHD, benign prostatic hyperplasia, and cystic fibrosis—the evidence we hold is insufficient to rate.
We have no effectiveness rating on file for the folate component of this product.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Mild sedation has occurred rarely and resolves quickly if you stop taking it.
Other rare reported side effects include irritability, insomnia, fatigue, memory impairment, headache, soft stools, nausea, vomiting, upper GI discomfort, and dry mouth—though for some of these, any link to glycine is unclear. Not enough reliable safety data exist for glycine in pregnancy or while breastfeeding, so the safety data advises against use unless your doctor approves.
We have no pregnancy or breastfeeding safety information on file for the folate in this product.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril), an antipsychotic, do not start this product without talking to your doctor first—glycine may make it less effective. For any other medications you're on, use the interaction checker below to see what we have on file; we could not check the folate component for interactions.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
MethylPro L-Methylfolate is worth considering if you're looking to supplement folate and glycine, though evidence for glycine's benefit outside schizophrenia treatment is limited. If you take clozapine for schizophrenia, you should not add this product without talking to your doctor first—the interaction suggests it could reduce how well your medication works.
Before starting, check your exact medications with the tool on this page and confirm with your pharmacist or doctor.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Methylfolate 1 mg, straight from the product label.
| Brand | MethylPro |
|---|---|
| Barcode (UPC) | 838287008002 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 21, 2022 |
| DSLD ID | 274162 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Methylfolate 1 mg by MethylPro, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Glycine | 270 mg | -- |
| Folate | 1.7 mg DFE | 418% |
| Folate | 1.7 mg | -- |
Other ingredients: Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Caution: Pregnant or lactating women, or individuals taking prescription medications, consult your healthcare professional before taking this product.
Keep tightly closed in a cool, dry place, out of the reach of children.
Directions: Use only as directed by a healthcare professional.
Storage
Keep tightly closed in a cool, dry place, out of the reach of children.
Formulation
Egg free Gluten free Free of nuts Dairy free
Manufactured in a GMP Compliant Facility
Formula
Professional strength L-Methylfolate
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Use only as directed by a healthcare professional.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Methylfolate 1 mg by MethylPro label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Methylfolate 1 mg by MethylPro
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
Glycine monograph & interactionsFolate
- › Folate
Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.
L-Methylfolate 1 mg by MethylPro Drug Interactions
HelloPharmacist Interaction Report
MethylPro L-Methylfolate 1 mg contains glycine, which has a documented interaction with clozapine (Clozaril), an antipsychotic medication.
In a small clinical study, adding glycine to clozapine therapy worsened schizophrenia symptoms compared with clozapine alone, suggesting glycine may decrease how well clozapine works. The mechanism behind this isn't fully understood.
Read the full breakdown — every affected drug type, severity by severity
The folate in this product—we could not check it for interactions, so we hold no data on how it interacts with medications. If you take any prescription medications, run them through the checker below to see what we do have on file.
Altogether, these interactions span 1 individual medication.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Methylfolate 1 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Methylfolate 1 mg interact with 1 drug. Click any drug to see the details.
1 of the 2 ingredients in L-Methylfolate 1 mg interact with drugs. Each result below shows which ingredient is responsible. Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with L-Methylfolate 1 mg — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Methylfolate 1 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for L-Methylfolate 1 mg, from the product label.
MethylPro
See all MethylPro products- Name
- Metabolic Maintenance
- Street Address
- 601 N Larch Street
- City
- Sisters
- State
- Oregon
- ZipCode
- 97759
- Phone Number
- 888-242-5327
- Web Address
- MethylPro.com
L-Methylfolate 1 mg by MethylPro: Common Questions
Does L-Methylfolate 1 mg by MethylPro interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is L-methylfolate and why is it in this product?
Is glycine safe for long-term use?
What side effects might I experience?
Can I take this product if I'm pregnant or breastfeeding?
Does this product help with ADHD or other conditions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Methylfolate 1 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Methylfolate 1 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Methylfolate 1 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC