L-Methylfolate 10 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Methylfolate 10 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Methylfolate 10 mg is a dietary supplement by Metabolic Maintenance with 2 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Methylfolate 10 mg by Metabolic Maintenance
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Methylfolate 10 mg by Metabolic Maintenance — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Methylfolate 10 mg by Metabolic Maintenance
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has 2 active ingredients: glycine and folate (as L-methylfolate at 10 mg per capsule). Glycine is an amino acid your body uses for various functions, while folate is a B vitamin involved in cell division and DNA synthesis.
The capsule also contains cellulose as an inactive ingredient.
Does it work?
Moderate evidence
Glycine is possibly effective for schizophrenia based on current evidence, though it appears to work better as a standalone treatment or in combination with other agents — adding it to clozapine specifically may backfire. For other uses listed in the data (3-phosphoglycerate dehydrogenase deficiency, ADHD, benign prostatic hyperplasia, and cystic fibrosis), the evidence we hold is insufficient to rate whether it works.
We have no effectiveness data on file for the folate component in this product.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Rarely, people have reported mild sedation, irritability, insomnia, fatigue, memory problems, headache, soft stools, nausea, vomiting, or GI discomfort — these symptoms resolve quickly if you stop taking it.
There isn't enough reliable safety data to say whether glycine is safe during pregnancy or while breastfeeding, so talk with your doctor or pharmacist before using this product if either applies to you. We hold no pregnancy or breastfeeding safety data for the folate in this formulation.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril), an antipsychotic medication, you'll want to clear this product with your doctor or pharmacist first — glycine may reduce its effectiveness. No other interactions are documented for the ingredients we could check.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product is worth considering if you're exploring natural support options — just know the glycine component is possibly effective for schizophrenia as a standalone, but may actually interfere with clozapine if you take that medication. If you're on clozapine or any other psychiatric drugs, check with your doctor or pharmacist before adding this to your routine.
Long-term safety data are limited, so a conversation with your healthcare provider is a good idea regardless.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Methylfolate 10 mg, straight from the product label.
| Brand | Metabolic Maintenance |
|---|---|
| Barcode (UPC) | 838287005193 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2023 |
| DSLD ID | 273982 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Methylfolate 10 mg by Metabolic Maintenance, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Glycine | 260 mg | -- |
| Folate | 16.7 mg DFE | 4175% |
| Folate | 10 mg | -- |
Other ingredients: Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Caution: Pregnant or lactating women, or individuals taking prescription medications, consult your healthcare professional before taking this product.
Keep tightly closed in a cool, dry place, out of the reach of children.
Storage
Keep tightly closed in a cool, dry place out of the reach of children.
Formulation
Egg free Gluten free Free of nuts Dairy free
Manufactured in a GMP Compliant Facility
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Use only as directed by a healthcare professional.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Methylfolate 10 mg by Metabolic Maintenance label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Methylfolate 10 mg by Metabolic Maintenance
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
Glycine monograph & interactionsFolate
- › Folate
Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.
L-Methylfolate 10 mg by Metabolic Maintenance Drug Interactions
HelloPharmacist Interaction Report
Metabolic Maintenance's L-Methylfolate 10 mg contains glycine, which has one documented interaction we need to flag.
Glycine may reduce how well clozapine (Clozaril), an antipsychotic medication, works. A small clinical study in patients with schizophrenia found that adding glycine to clozapine actually made symptoms worse compared to clozapine alone, though we don't yet understand exactly why this happens.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 1 individual medication. The folate component in this product — we couldn't check for interactions because the ingredient list shows it as a blend and we hold no separate data for it.
If you take clozapine or any other psychiatric medications, run them through the interaction checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Methylfolate 10 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Methylfolate 10 mg interact with 1 drug. Click any drug to see the details.
1 of the 2 ingredients in L-Methylfolate 10 mg interact with drugs. Each result below shows which ingredient is responsible. Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with L-Methylfolate 10 mg — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Methylfolate 10 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for L-Methylfolate 10 mg, from the product label.
Metabolic Maintenance
See all Metabolic Maintenance products- Name
- Metabolic Maintenance
- Street Address
- 601 N Larch Street
- City
- Sisters
- State
- Oregon
- ZipCode
- 97759
- Phone Number
- 800-772-7873
- Web Address
- MetabolicMaintenance.com
L-Methylfolate 10 mg by Metabolic Maintenance: Common Questions
Does L-Methylfolate 10 mg by Metabolic Maintenance interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is glycine safe to take long-term?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I experience?
Why can't you check the folate for interactions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Methylfolate 10 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Methylfolate 10 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Methylfolate 10 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC