L-Methylfolate 15 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Methylfolate 15 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Methylfolate 15 mg is a dietary supplement by Teraputics Pure Life with 3 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Methylfolate 15 mg by Teraputics Pure Life
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Methylfolate 15 mg by Teraputics Pure Life — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Methylfolate 15 mg by Teraputics Pure Life
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has 3 active ingredients: glycine, folate, and L-methylfolate. Glycine is an amino acid; folate and L-methylfolate are forms of a B vitamin involved in cell growth and DNA synthesis.
The capsule also contains hypromellose, an inactive ingredient that helps hold the capsule together.
Does it work?
Not established
The evidence we hold is strongest for glycine in schizophrenia, where it's rated possibly effective. For the other conditions listed (3-phosphoglycerate dehydrogenase deficiency, ADHD, benign prostatic hyperplasia, and cystic fibrosis), the data on glycine isn't established enough to rate.
We don't have effectiveness information on file for folate or L-methylfolate in this product.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, but long-term safety data are limited. Rare side effects include mild sedation, soft stools, nausea, vomiting, and upper GI discomfort — all of which resolve quickly if you stop taking it.
Other effects reported include irritability, insomnia, fatigue, headache, and memory problems, though it's unclear if glycine was the cause. There isn't enough reliable safety data to know whether glycine is appropriate during pregnancy or breastfeeding — talk it over with your doctor or pharmacist for personalized advice.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril), this product warrants a conversation with your doctor or pharmacist before you begin. For other medications, we couldn't check the folate and L-methylfolate components — run your exact drug names through the interaction checker on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product may be worth considering if you're interested in folate supplementation and your doctor approves. If you take clozapine for schizophrenia, check with your doctor or pharmacist first — the glycine in this product may worsen symptoms.
For any other medications, verify them with the tool on this page before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Methylfolate 15 mg, straight from the product label.
| Brand | Teraputics Pure Life |
|---|---|
| Barcode (UPC) | X002LI4R27 |
| Net contents | 120 Vegan Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 268758 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Methylfolate 15 mg by Teraputics Pure Life, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Glycine | 250 mg | -- |
| Folate | 25 mg DFE | 6250% |
| L-Methylfolate | 15 mg | -- |
| Folate | 20.5 mg | -- |
Other ingredients: Hypromellose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: For adults, take one (1) capsule daily preferably with a meal.
Formula
15mg L-methylfolate (L-5-MTHF) + glycine
L-methylfolate Metabolically active form of folic acid
Formulation
Promotes cardiovascular & nervous system health Supports positive mood & emotional well-being May help with sleep, concentration, energy High potency formula Maximum strength
Vegan, non-GMO & gluten free
Vegan, non-GMO & gluten free
Professional strength
Contains zero GMOs, soy, animal by-products, artificial flavors, colors, sweeteners, sugar, preservatives, starch, milk, lactose, gluten, wheat, yeast, fish, sodium
Sourced from a FDA registered facility Formulated in the USA Sourced from a GMP registered facility Good manufacturing practice Certified 3rd party tested
Non GMO
Vegan
Precautions
Caution: Do not exceed recommended dose.
Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of the reach of children.
Do not use if safety seal is damaged or missing.
Storage
Store in a cool, dry place.
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Methylfolate 15 mg by Teraputics Pure Life label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Methylfolate 15 mg by Teraputics Pure Life
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegan Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
Glycine monograph & interactionsFolate
Folate
- › L-Methylfolate
Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.
L-Methylfolate 15 mg by Teraputics Pure Life Drug Interactions
HelloPharmacist Interaction Report
L-Methylfolate 15 mg by Teraputics Pure Life contains glycine, which has a documented interaction with clozapine (Clozaril), an antipsychotic medication.
A small clinical study in people with schizophrenia found that adding glycine to clozapine made schizophrenia symptoms worse compared to clozapine alone, though the reason isn't fully understood.
Read the full breakdown — every affected drug type, severity by severity
We couldn't check the other active ingredients — folate and L-methylfolate — because we hold no interaction data for them. That doesn't mean they're safe to combine with any medication; it means we simply don't have the information to evaluate them.
If you take clozapine, you'll want to talk with your doctor or pharmacist before starting this product. For any other medications you're on, use the interaction checker on this page to look up your exact drug names.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Methylfolate 15 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Methylfolate 15 mg interact with 1 drug. Click any drug to see the details.
1 of the 3 ingredients in L-Methylfolate 15 mg interact with drugs. Each result below shows which ingredient is responsible. Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with L-Methylfolate 15 mg — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Methylfolate 15 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for L-Methylfolate 15 mg, from the product label.
Teraputics Pure Life
See all Teraputics Pure Life products- Name
- Teraputics Inc
- Street Address
- P.O. Box 1147
- City
- New York
- State
- NY
- ZipCode
- 10002
- Web Address
- teraputics.com
L-Methylfolate 15 mg by Teraputics Pure Life: Common Questions
Does L-Methylfolate 15 mg by Teraputics Pure Life interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is L-methylfolate, and why is it in this supplement?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I notice?
Is this product for ADHD or cystic fibrosis?
How long can I safely take this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Methylfolate 15 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Methylfolate 15 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Methylfolate 15 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC