L-Proline 500 mg Ingredients & Drug Interactions
by NOW
What is this page for?
First and foremost: checking L-Proline 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Proline 500 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for joint and connective tissue support, skin health and wound healing, collagen production.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of L-Proline 500 mg by NOW
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-proline, a building-block amino acid your body uses to make collagen and other connective tissues. The capsule also holds cellulose, stearic acid, and silica as inactive ingredients — the binders and fillers that hold it together.
Does it work?
Not established
The evidence we hold shows insufficient reliable data to rate L-proline for athletic performance, wound healing, bone strength, osteoporosis, osteopenia, or fractures. That doesn't mean it doesn't work for these purposes — it means the studies so far aren't solid enough to say.
If you're considering it for a specific health goal, talk it over with your doctor or pharmacist.
How safe is it?
Some data gaps
L-proline comes naturally in food and is generally considered low-risk from diet sources. However, safety data on supplemental doses — the kind in this capsule — hasn't been well studied.
The data advises caution with extra amounts beyond what food provides, and there isn't enough reliable information to know whether supplemental doses are safe while breastfeeding. If you're pregnant or nursing, check with your doctor or pharmacist before starting.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredient we could check.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and some safety-information gaps remain.
This supplement is a single amino acid with no documented medication interactions, but evidence for its effectiveness is still being built. It's generally well tolerated from food sources, though safety data on supplements like this one is limited.
If you're interested in it for bone health, wound healing, or athletic performance, talk with your doctor or pharmacist to see whether it makes sense for you and what dose, if any, they'd recommend.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2015.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Proline 500 mg, straight from the product label.
| Brand | NOW |
|---|---|
| Barcode (UPC) | 733739001337 |
| Net contents | 120 Veg Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 23, 2015 |
| DSLD ID | 55105 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Proline 500 mg by NOW, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Proline | 1 Gram(s) | -- |
Other ingredients: Cellulose, Stearic Acid, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 2 capsules 1 to 2 times daily, preferably on an empty stomach.
General Statements
L-Proline is an amino acid that is necessary for collagen production.* Collagen is the main structural protein that constitutes all human connective tissues, including skin, tendons, ligaments, joints, bone, and blood vessels (veins and arteries).* L-Proline is therefore a building block that helps to stabilize and strengthen the structural components of the body.* Although Proline is naturally produced in the body, in specific high-demand situations, a regular diet may not be sufficient to respond to the body’s need for Proline.*
CAPSULE SIZE
Structural Support*
Collagen Production*
Amino Acids
Family owned since 1968.
Natural color variation may occur in this product. Please Recycle.
Please Recycle.
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Caution: For adults only.
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Keep out of reach of children.
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Do Not Eat Freshness Packet. Keep in Bottle.
Seals/Symbols
Non-GMO
GMP QUALITY ASSURED
FDA Statement of Identity
A Dietary Supplement
Formulation
Vegetarian/Vegan
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.
Storage
Store in a cool, dry place after opening.
General
CODE 0133 V2
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Proline 500 mg by NOW label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Proline 500 mg by NOW
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Veg Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
L-Proline
No knowninteractions
Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of...
L-Proline monograph & interactionsOther (inactive) ingredients: Cellulose, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.
L-Proline 500 mg by NOW Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in L-Proline 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for L-Proline 500 mg, from the product label.
NOW
See all NOW products- Name
- NOW Foods
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
- Web Address
- nowfoods.com
L-Proline 500 mg by NOW: Common Questions
Does L-Proline 500 mg by NOW interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is L-proline and what does it do in your body?
Does L-proline actually help with wound healing, bone strength, or athletic performance?
Is it safe to take L-proline while I'm pregnant or breastfeeding?
What side effects have been reported with L-proline?
Does this product have fillers or artificial ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Proline 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Proline 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Proline 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proline 4 references
- Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
- Gracia-Marco L, Bel-Serrat S, Cuenca-Garcia M, et al. Amino acids intake and physical fitness among adolescents. Amino Acids. 2017;49(6):1041-1052. PubMed
- Jamdar J, Rao B, Netke S, et al. Reduction in tibial shaft fracture healing time with essential nutrient supplementation containing ascorbic acid, lysine, and proline. J Altern Complement Med. 2004;10(6):915-6.
- Mehl AA, Damião AO, Viana SD, Andretta CP. Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair. J Wound Care 2021;30(1):26-31. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC