No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Proline Ingredients & Drug Interactions

by BulkSupplements.com

Powder Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

L-Proline is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for joint and connective tissue support, skin health and wound healing, collagen production.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Proline by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-proline, a naturally occurring amino acid. That's it — no fillers or other active ingredients.

L-proline is a building block your body uses in collagen and connective tissue.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Proline product and its label doesn't state a use — see Proline's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold for L-proline doesn't yet support a clear benefit for athletic performance, bone density (osteoporosis or osteopenia), fractures, or wound healing. All those areas are rated as having insufficient reliable evidence.

The research simply isn't there yet to say whether supplemental doses would help.

The evidence, ingredient by ingredient Proline

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-proline from food is generally well tolerated, but supplement safety at higher-than-food doses hasn't been well studied. The data we have advises against taking extra amounts unless your doctor specifically recommends it.

Safety during breastfeeding is not established, so if you're breastfeeding, talk with your doctor or pharmacist before starting it. Pregnancy safety data isn't on file for this ingredient.

Side effects, ingredient by ingredient Proline

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for L-proline in the data we hold.

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and some safety-information gaps remain.

L-proline is a straightforward amino acid with no documented medication interactions, but the evidence for its effectiveness at the doses in supplements isn't solid yet. If you're considering it for bone health, athletic performance, or wound healing, chat with your doctor or pharmacist about whether it makes sense for you — especially if you're pregnant, breastfeeding, or planning to take it long-term.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Proline, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000HUTG7H
Net contents 1 kg; 35.3 oz
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 252818
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Proline by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2000 mg
Maximum serving Sizes:
2000 mg
Servings per container
500
UPC/BARCODE
X000HUTG7H
IngredientAmount% DV
L-Proline2000 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

New - BulkSupplements L-Proline Powder (1 Kilogram)

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 2000 mg (about 3/4 tsp) once or twice daily, or as directed by a physician.

Storage

Store in a dry, cool place

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

See for yourself

L-Proline by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Proline by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2000 mg Dosage formPowder Servings per container500 Amounts shown are per serving.

L-Proline

No known
interactions
2000 mg per serving

Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of...

L-Proline monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Proline by BulkSupplements.com Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Proline. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Proline, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

L-Proline by BulkSupplements.com: Common Questions

Does L-Proline by BulkSupplements.com interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Proline. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Proline contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does L-proline interact with any medications?
No interactions are documented in our data for this ingredient. That said, it's always smart to check your specific medications with the tool on this page or with your pharmacist before you start.
Is L-proline safe during pregnancy?
We don't have pregnancy safety data on file for L-proline. Talk with your doctor or pharmacist about whether it's right for you if you're pregnant or planning to be.
Can I take L-proline while breastfeeding?
Safety data on supplemental doses while breastfeeding isn't established. Your doctor or pharmacist can help you decide whether it's okay for your situation.
Does L-proline actually work for bone health or athletic performance?
The evidence we hold doesn't yet support clear benefits for athletic performance, bone density, fractures, or wound healing — all rated as having insufficient reliable evidence. More research is needed.
What does L-proline do in the body?
L-proline is an amino acid your body uses to build and maintain collagen and connective tissue. It's found naturally in protein-rich foods.
Are there any side effects from L-proline?
We don't have documented adverse effects from the trials we hold data on. However, supplement safety at higher doses hasn't been well studied, so it's best to take it only if your doctor recommends it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Proline is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Proline label
Go deeper

The Full Monographs Behind L-Proline’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Proline's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proline 4 references
  1. Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
  2. Gracia-Marco L, Bel-Serrat S, Cuenca-Garcia M, et al. Amino acids intake and physical fitness among adolescents. Amino Acids. 2017;49(6):1041-1052. PubMed
  3. Jamdar J, Rao B, Netke S, et al. Reduction in tibial shaft fracture healing time with essential nutrient supplementation containing ascorbic acid, lysine, and proline. J Altern Complement Med. 2004;10(6):915-6.
  4. Mehl AA, Damião AO, Viana SD, Andretta CP. Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair. J Wound Care 2021;30(1):26-31. PubMed

See these in context on the Proline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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