No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Proline Ingredients & Drug Interactions

by PureBulk.com

Powder Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

L-Proline is a dietary supplement by PureBulk.com with 1 active ingredient. Its ingredients are commonly taken for joint and connective tissue support, skin health and wound healing, collagen production.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Proline by PureBulk.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-Proline, an amino acid (a building block your body uses to make proteins). L-Proline is naturally present in many foods and plays a role in connective tissue formation.

The product is a powder with no other active ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Proline product and its label doesn't state a use — see Proline's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on L-Proline for athletic performance, osteoporosis, fractures, wound healing, and osteopenia is insufficient to rate — meaning reliable studies are lacking or mixed. We don't have enough solid data to say whether it works for these purposes.

The evidence, ingredient by ingredient Proline

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Proline is generally well tolerated from food sources, but supplement safety at higher doses hasn't been well studied. The safety data we hold advises caution with supplemental doses beyond food amounts unless your doctor directs you to take them.

There isn't enough reliable information on supplemental doses while breastfeeding, so caution is warranted if you're nursing — talk with your doctor or pharmacist about whether it's right for you.

Side effects, ingredient by ingredient Proline

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for L-Proline with any medications. That said, run your specific drugs through the search tool on this page to be thorough, or ask your pharmacist if you want a second pair of eyes.

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and some safety-information gaps remain.

L-Proline is an amino acid sometimes used for joint and connective tissue support, though the evidence for its effectiveness isn't established in our data. If you're nursing or pregnant, or if you want to take more than what's in food, check with your doctor or pharmacist first — they know your full health picture and can advise whether it's a fit.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Proline, straight from the product label.

Brand PureBulk.com
Net contents 100 g; 3.53 oz.
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 23147
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Proline by PureBulk.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2000 mg
Maximum serving Sizes:
2000 mg
Servings per container
50
IngredientAmount% DV
L-Proline2000 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Storage: Keep dry, cool & dark

Formulation

Free of: soy, dairy, yeast, gluten, corn and additives.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 2000 mg (scant 1 tsp) once or twice daily, or as directed by physician.

General Statements

US Standard Measuring Spoons Spoon Size (level) milligrams 1/4 teaspoon 606 1/2 teaspoon 1212 1 teaspoon 2425

Precautions

Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.

Consult your physician before use.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

L-Proline by PureBulk.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Proline by PureBulk.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2000 mg Dosage formPowder Servings per container50 Amounts shown are per serving.

L-Proline

No known
interactions
2000 mg per serving

Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of...

L-Proline monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Proline by PureBulk.com Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Proline. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Proline, from the product label.

PureBulk.com

See all PureBulk.com products
Name
PureBulk.com
City
Roseburg
State
OR
ZipCode
97471
Phone Number
(541) 679-1500
Web Address
PureBulk.com
Pharmacist Counseling Corner

L-Proline by PureBulk.com: Common Questions

Does L-Proline by PureBulk.com interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Proline. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Proline contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-Proline safe if I'm pregnant?
There isn't enough reliable data to know either way. Talk with your doctor or pharmacist before taking it during pregnancy — they can weigh what you need against what the evidence shows.
Is it safe while I'm breastfeeding?
The safety data on supplemental doses while breastfeeding isn't established, so caution is advised. Check with your doctor or pharmacist before adding this to your routine if you're nursing.
Does L-Proline help with wound healing?
The evidence we hold on L-Proline for wound healing is insufficient to rate — meaning we don't have enough reliable studies to say whether it works. Don't rely on this product alone if you're dealing with a wound that needs care.
Can I take more than the recommended dose?
There isn't enough reliable data on supplemental doses above normal amounts, so it's best to stick with your doctor's advice. If you want to take more, talk with them or your pharmacist first.
What is L-Proline used for in the body?
L-Proline is an amino acid your body uses to build and repair connective tissues like collagen. It's naturally found in many foods and is part of the protein your body makes every day.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Proline is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Proline label
Go deeper

The Full Monographs Behind L-Proline’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Proline's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proline 4 references
  1. Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
  2. Gracia-Marco L, Bel-Serrat S, Cuenca-Garcia M, et al. Amino acids intake and physical fitness among adolescents. Amino Acids. 2017;49(6):1041-1052. PubMed
  3. Jamdar J, Rao B, Netke S, et al. Reduction in tibial shaft fracture healing time with essential nutrient supplementation containing ascorbic acid, lysine, and proline. J Altern Complement Med. 2004;10(6):915-6.
  4. Mehl AA, Damião AO, Viana SD, Andretta CP. Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair. J Wound Care 2021;30(1):26-31. PubMed

See these in context on the Proline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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