No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Serine 2000 mg Ingredients & Drug Interactions

by Double Wood Supplements

Capsule Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

L-Serine 2000 mg is a dietary supplement by Double Wood Supplements with 1 active ingredient. Its ingredients are commonly taken for memory and brain health, nervous system disorders (e.g., als research), mood and stress support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Serine 2000 mg by Double Wood Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: L-serine, a naturally occurring amino acid. The capsules also hold two inactive ingredients — hypromellose (a capsule binder) and rice flour (a filler).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: brain health, cognitive activity, and sleep quality.
  • We looked for evidence on: Cognitive function, Insomnia, Circadian rhythm sleep disorders, Alzheimer disease, Parkinson disease, memory — and 2 related terms.
  • The closest evidence on file: Serine is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Serine is rated "Insufficient Reliable Evidence To Rate" for Circadian rhythm sleep disorders, Cognitive function, Insomnia, Parkinson disease.

L-serine is possibly effective for schizophrenia based on the evidence we have on file. For Alzheimer disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), back pain, post-traumatic stress disorder (PTSD), and cognitive function, the current evidence is insufficient to rate how well it works — meaning we don't have enough reliable data yet to say one way or the other.

The evidence, ingredient by ingredient Serine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-serine appears to be well tolerated at medicinal doses, though side effects tend to depend on how much you take. The most common ones are gastrointestinal — stomach pain, bloating, indigestion, loss of appetite, and nausea.

At very high doses (over about 25 grams daily), seizures have been reported rarely, along with a reversible eye movement disorder (nystagmus). There isn't enough safety data to recommend this supplement during pregnancy, so it's best avoided unless your doctor advises otherwise.

Safety during breastfeeding hasn't been studied, so avoid it unless your doctor directs you to take it. While serine from food is generally considered low-risk, long-term safety of the supplement form is not well established.

Side effects, ingredient by ingredient Serine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for L-serine in our data. Still, if you're on any medications and want to be thorough, use the interaction checker below to search your specific drugs.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

L-serine may be worth considering if you're interested in schizophrenia support, though talk with your doctor first about whether it fits your situation. If you're pregnant, nursing, or taking any medications, check with your doctor or pharmacist before starting.

No interactions are documented with medications we have data for, but that's not a blanket safety assurance — your own provider should review your full picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Serine 2000 mg, straight from the product label.

Brand Double Wood Supplements
Barcode (UPC) 859793007303
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 241810
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Serine 2000 mg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
45
UPC/BARCODE
859793007303
IngredientAmount% DV
L-Serine2000 mg--

Other ingredients: Hypromellose, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

L-Serine is an amino acid produced naturally by the body that plays an important role in the body's production of proteins, DNA, and cell membranes. When taken as a supplement, L-Serine spurs production of important amino acids and neurotransmitters including L-Tryptophan, L-Cystine, and Serotonin. Research has shown L-Serine supplementation to provide benefits to brain, skin, and muscle health.

L-Serine 2000 mg per serving

Suggested/Recommended/Usage/Directions

Suggested Use: As a supplement, take 4 capsules per day. L-Serine is water soluble and does not need to be taken with food. Do not exceed 12 capsules per day.

Storage

Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature.

Formulation

Stimulates production of L-Tryptophan, L-Cystine, and Serotonin Supports brain health and cognitive activity Supports sleep quality

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Consult your physician before use if you are taking any medications. Do not use L-Serine if you are pregnant, nursing, or are under 18 years of age.

Discontinue use and consult your doctor immediately if any adverse reactions occur.

Do not take L-Serine and operate heavy machinery.

Keep out of reach of children.

Do not exceed 12 capsules per day.

Do not use L-Serine if you are pregnant, nursing, or are under 18 years of age.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

NPN: 80103759

See for yourself

L-Serine 2000 mg by Double Wood Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Serine 2000 mg by Double Wood Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

L-Serine

No known
interactions
2000 mg per serving

Serine is an amino acid your body can make on its own and also gets from protein-rich foods, so most people do not need a supplement. L-serine has bee...

L-Serine monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Serine 2000 mg by Double Wood Supplements Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Serine 2000 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Serine 2000 mg, from the product label.

Double Wood Supplements

See all Double Wood Supplements products
Name
Double Wood LLC
Street Address
3510 Scotts Ln Ste 219
City
Philadelphia
State
PA
ZipCode
19129-1573
Web Address
www.doublewoodsupplements.com
Pharmacist Counseling Corner

L-Serine 2000 mg by Double Wood Supplements: Common Questions

Does L-Serine 2000 mg by Double Wood Supplements interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Serine 2000 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Serine 2000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-serine, and what is it supposed to do?
L-serine is an amino acid your body uses to build proteins and support nerve function. In this product it's being used at 2,000 mg per dose, mainly studied for schizophrenia support — where it's shown promise — and investigated for several other conditions like Alzheimer disease and cognitive decline, though the evidence for those isn't solid yet.
What are the most common side effects?
Stomach upset — including bloating, pain, indigestion, nausea, and loss of appetite — is the most common issue, and it tends to show up more at higher doses. These effects are generally mild and appear to be dose-dependent, meaning they're less likely at lower amounts.
Is L-serine safe to take while pregnant or breastfeeding?
There isn't enough safety data for either pregnancy or breastfeeding, so the guidance is to avoid it unless your doctor specifically advises you to take it. Talk with your doctor or pharmacist if you're considering this while pregnant or nursing.
Can I take this long-term?
Long-term safety of supplemental L-serine hasn't been well established, so if you're thinking about taking it regularly, it's worth discussing with your doctor or pharmacist first.
Does this product have fillers?
Yes — it contains rice flour as a filler and hypromellose as part of the capsule material. If you're sensitive to either, check the label or ask the manufacturer for alternatives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Serine 2000 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Serine 2000 mg label
Go deeper

The Full Monographs Behind L-Serine 2000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Serine 2000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serine 3 references
  1. Fridman V, Suriyanarayanan S, Novak P, et al. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019;92(4):e359-e370.
  2. Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed
  3. Levine TD, Miller RG, Bradley WG, et al. Phase I clinical trial of safety of L-serine for ALS patients. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(1-2):107-111. PubMed

See these in context on the Serine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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