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Dietary supplement

Rhodiola Rosea Extract 500 mg Ingredients & Drug Interactions

by Double Wood Supplements

Rhodiola Rosea Extract 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Rhodiola Rosea Extract 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Rhodiola Rosea Extract 500 mg is a dietary supplement by Double Wood Supplements with 2 active ingredients. Its ingredients are commonly taken for fatigue and low energy, stress and coping (adaptogen), mental performance and focus.Based on those ingredients, 1,271 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rhodiola rosea root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Rhodiola Rosea Extract 500 mg by Double Wood Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Rhodiola Rosea Extract 500 mg by Double Wood Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Rhodiola Rosea Extract 500 mg by Double Wood Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients, both of which are rhodiola rosea root extract — the same ingredient listed twice. Each capsule delivers 500 mg of rhodiola extract.

The product also contains several inactive ingredients (hypromellose, microcrystalline cellulose, and silicon dioxide) that form the capsule and help with stability.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Rhodiola's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support stress tolerance and promote energy levels.
  • We looked for evidence on: Stress, Fatigue, Chronic fatigue syndrome (CFS), Depression, Generalized anxiety disorder (GAD), mental performance — and 2 related terms.
  • The closest evidence on file: Rhodiola is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD) (Natural Medicines).
  • Also on file: Rhodiola is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), Depression, Fatigue, Stress.

The evidence for rhodiola rosea extract isn't established in the data we hold. The product's studied uses include altitude sickness, generalized anxiety disorder, heart rhythm issues, athletic performance, and bladder cancer — but our data rates all of them as having insufficient reliable evidence to make a firm claim about whether it works.

The evidence, ingredient by ingredient Rhodiola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rhodiola is generally well tolerated for short-term use, but long-term safety hasn't been well studied. The most common side effects are dizziness and changes in saliva production — either dry mouth or excessive saliva.

During pregnancy, not enough safety data exists, so the safety data advises against it. The same applies to breastfeeding — there isn't enough data to know whether it's safe, so it's best avoided while nursing.

If you're pregnant or breastfeeding and interested in taking rhodiola, talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Rhodiola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rhodiola.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,272 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Rhodiola Rosea Extract 500 mg, double-check your medications with your doctor or pharmacist if you take blood pressure drugs (antihypertensive medications), blood sugar medications (antidiabetes drugs), drugs that suppress your immune system (immunosuppressants), or any medication your liver clears through the CYP2C9 enzyme — especially losartan. Also mention any drugs metabolized by P-glycoprotein or the CYP1A2 or CYP3A4 pathways.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Rhodiola may help with certain conditions, but the evidence isn't solid in our data. Its biggest concern is combining it with blood pressure medications or drugs your liver clears through the CYP2C9 pathway, like losartan.

If you take any prescription medications — especially for blood pressure, blood sugar, or after a transplant — check them against this product with your doctor or pharmacist before starting. Avoid it during pregnancy and breastfeeding unless you've discussed it with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rhodiola Rosea Extract 500 mg, straight from the product label.

Brand Double Wood Supplements
Barcode (UPC) X001UEK187
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 241941
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rhodiola Rosea Extract 500 mg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
120
UPC/BARCODE
X001UEK187
IngredientAmount% DV
Rhodiola rosea root extract375 mg--
Rhodiola rosea root extract125 mg--

Other ingredients: Hypromellose, Microcrystaline Cellulose, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Product Information: Rhodiola Rosea is a flowering herb that grows in cold, high altitude regions of Europe and Asia. When taken as a supplement it has been shown to support neuro-protection, support stress tolerance, and promote energy levels. These benefits are derived primarily from the Salidroside content as well as the Tyrosol content.

Rhodiola Rosea Extract 500 mg per veggie capsule

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 capsule in the morning or as needed. Some studies have shown taking too high a dose may actually decrease response. We don't recommend taking more than 2 capsules at one time.

Storage

Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature.

Precautions

Warning: Consult your physician before using this product. Do not consume more than 4 capsules per day.

Do not take this product if you are pregnant, nursing, or taking other medication.

Discontinue use and consult your doctor immediately if any adverse reactions occur.

Do not take Rhodiola Rosea Extract and operate any heavy machinery until you know how it affects you.

Keep out of reach of children.

Seals/Symbols

Proudly made in USA

Formulation

Made with Non-GMO ingredients Gluten free

Supports mental and physical endurance Promotes cognitive acuity and longevity Supports stress tolerance

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Rhodiola Rosea Extract DoubleWood Supplements New

NPN: 80090493

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rhodiola Rosea Extract 500 mg by Double Wood Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Rhodiola Rosea Extract 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Rhodiola Rosea Extract 500 mg by Double Wood Supplements

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Rhodiola rosea root extract

Interacts with
1,271 drugs
375 mg per serving Form: Salidrosides

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola rosea root extract monograph & interactions

Rhodiola rosea root extract

Interacts with
1,271 drugs
125 mg per serving Form: Rosavins, Salidrosides

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola rosea root extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystaline Cellulose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rhodiola Rosea Extract 500 mg by Double Wood Supplements Drug Interactions

Want to check YOUR meds against Rhodiola Rosea Extract 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,271Drugs
624 Moderate 647 Minor

Ingredients driving the most interactions

Rhodiola rosea root extract 1,271

Individual Drug Interactions

The ingredients in Rhodiola Rosea Extract 500 mg interact with 1,271 drugs. Click any drug to see the details.

1 of the 2 ingredients in Rhodiola Rosea Extract 500 mg interact with drugs. Each result below shows which ingredient is responsible. Rhodiola rosea root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Rhodiola Rosea Extract 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Rhodiola rosea root extract10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Rhodiola rosea root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rhodiola Rosea Extract 500 mg, from the product label.

Double Wood Supplements

See all Double Wood Supplements products
Name
Double Wood LLC
Street Address
3510 Scotts Ln Ste 219
City
Philadelphia
State
PA
ZipCode
19129-1573
Web Address
www.doublewoodsupplements.com
Pharmacist Counseling Corner

Rhodiola Rosea Extract 500 mg by Double Wood Supplements: Common Questions

Does Rhodiola Rosea Extract 500 mg by Double Wood Supplements interact with any medications?
Yes. Based on its ingredients, Rhodiola Rosea Extract 500 mg has a known interaction with 1,271 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rhodiola Rosea Extract 500 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
No — not enough safety data exists, so the safety data advises against it during pregnancy. Talk with your doctor or pharmacist before taking rhodiola if you're pregnant or trying to become pregnant.
Can I take this while breastfeeding?
No — not enough safety data exists, so the safety data advises against it while breastfeeding. Discuss it with your doctor or pharmacist to decide what's best for you and your baby.
What are the most common side effects?
The most common side effects are dizziness and changes in saliva production — either dry mouth or excessive saliva. Rhodiola is generally well tolerated, though long-term safety hasn't been well studied.
Does this product actually work for anxiety or stress?
Our data rates the evidence for generalized anxiety disorder as insufficient reliable evidence to know whether it works. While some people use rhodiola for stress, the science behind it isn't established in the data we hold.
Why is the same ingredient listed twice?
Both active ingredients in this product are rhodiola rosea root extract. The product contains 500 mg total, and the ingredient appears twice in the ingredient list.
What's in this besides the active ingredient?
The capsule contains hypromellose, microcrystalline cellulose, and silicon dioxide — these are inactive ingredients that form the capsule and help keep the product stable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rhodiola Rosea Extract 500 mg label
Go deeper

The Full Monographs Behind Rhodiola Rosea Extract 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rhodiola

Interacts with 1,271 drugs

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...

Read the full Rhodiola monograph →
Sources

Sources & How We Checked

Rhodiola Rosea Extract 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rhodiola 13 references
  1. Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19.
  2. Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32.
  3. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
  4. Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105. PubMed
  5. Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr 2006;15:433-41.
  6. Hellum BH, Tosse A, Hoybakk K, et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med 2010;76:331-8.
  7. Skopriska-Rozewska E, Wojcik R, Siwicki AK, et al. The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats. Pol J Vet Sci 2008;11:105-11.
  8. Mishra KP, Chanda S, Shukla K, Ganju L. Adjuvant effect of aqueous extract of Rhodiola imbricate rhizome on the immune responses to tetanus toxoid and ovalbumin in rats. Immunopharmacol Immunotoxicol 2010;32:141-6.
  9. Li HX, Sze SC, Tong Y, Ng TB. Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. J Ethnopharmacol 2009;123:257-66. PubMed
  10. Mishra KP, Ganju L, Chanda S, et al. Aqueous extract of Rhodiola imbricate rhizome stimulates Toll-like receptor 4, granzyme-B and Th1 cytokines in vitro. Immunobiology 2009;214:27-31.
  11. Thu OK, Nilsen OG, Hellum B. In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products. Pharm Bio. 2016 Dec;54(12):3249-3256.
  12. Thu OK, Spigset O, Nilsen OG, Hellum B. Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Eur J Clin Pharmacol. 2016 Mar;72(3):295-300. PubMed
  13. Woron J, Siwek M. Unwanted effects of psychotropic drug interactions with medicinal products and diet supplements containing plant extracts. Psychiatr Pol 2018;52(6):983-96. PubMed

See these in context on the Rhodiola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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