L-Serine 500 mg Ingredients & Drug Interactions
by Swanson
What is this page for?
First and foremost: checking L-Serine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Serine 500 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for memory and brain health, nervous system disorders (e.g., als research), mood and stress support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of L-Serine 500 mg by Swanson
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: AjiPure pharmaceutical grade L-Serine at 500 mg per capsule. L-Serine is an amino acid your body uses to build proteins and support nerve and brain function.
The capsule also contains inactive ingredients — rice flour, hypromellose, and calcium laurate — which are fillers and binders.
Does it work?
Moderate evidence
L-Serine shows possibly effective evidence for schizophrenia. For Alzheimer's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), back pain, post-traumatic stress disorder (PTSD), and cognitive function, the evidence isn't yet established well enough to rate.
If you're considering this for one of those other conditions, talk with your doctor about whether the current research supports it for your situation.
How safe is it?
Well-documented data
L-Serine appears well tolerated at medicinal doses, though side effects tend to be dose-dependent. The most common ones are gastrointestinal — belly pain, bloating, indigestion, loss of appetite, and nausea.
A small number of people taking very high doses (over 25 grams daily) have reported reversible eye movement problems (nystagmus) and seizures, though those are rare. There isn't enough safety data on L-Serine supplements in pregnancy, so it's best avoided unless your doctor advises otherwise.
Safety during breastfeeding hasn't been studied either, so supplements should be avoided unless your doctor directs it. Long-term supplement safety in general hasn't been well established.
Meds to double-check
No known interactions
No interactions are documented in our data for L-Serine with any medications. That said, if you're on any prescription drugs, feel free to use the medication checker on this page or ask your pharmacist for peace of mind.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
L-Serine 500 mg is a single-ingredient supplement with no documented drug interactions. It shows some promise for schizophrenia but lacks solid evidence for several other conditions people ask about.
Gastrointestinal side effects are the main concern at typical doses. Talk with your doctor before using it in pregnancy or while breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Serine 500 mg, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Serine 500 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| AjiPure pharmaceutical grade L-Serine | 500 mg | -- |
Other ingredients: Rice Flour, Hypromellose, Calcium Laurate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Brain and nervous system health
Formula
L-Serine 500 mg per capsule Featuring AjiPure
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take one veggie capsule per day with water.
Precautions
Warning: For adults only. Keep out of reach of children.
Consult your healthcare provider before using this or any product if you are pregnant or nursing, taking medication or have a medical condition.
Do not use if seal is broken.
Storage
Store in a cool, dry place.
Brand IP Statement(s)
AjiPure and the AjiPure logo are registered trademarks of Ajinomoto, Inc.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Serine 500 mg by Swanson label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Serine 500 mg by Swanson
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
AjiPure pharmaceutical grade L-Serine
No knowninteractions
Serine is an amino acid your body can make on its own and also gets from protein-rich foods, so most people do not need a supplement. L-serine has bee...
AjiPure pharmaceutical grade L-Serine monograph & interactionsOther (inactive) ingredients: Rice Flour, Hypromellose, Calcium Laurate. These complete the product’s ingredient list but are not active constituents.
L-Serine 500 mg by Swanson Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in L-Serine 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for L-Serine 500 mg, from the product label.
L-Serine 500 mg by Swanson: Common Questions
Does L-Serine 500 mg by Swanson interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is L-Serine, and what does it do in the body?
Does L-Serine work for schizophrenia?
What side effects might I get from taking L-Serine?
Is it safe to take L-Serine while pregnant or breastfeeding?
Does this product contain any fillers or binders?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Serine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Serine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Serine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Serine 3 references
- Fridman V, Suriyanarayanan S, Novak P, et al. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019;92(4):e359-e370.
- Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed
- Levine TD, Miller RG, Bradley WG, et al. Phase I clinical trial of safety of L-serine for ALS patients. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(1-2):107-111. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC