No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Serine Ingredients & Drug Interactions

by BulkSupplements.com

Powder Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

L-Serine is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for memory and brain health, nervous system disorders (e.g., als research), mood and stress support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Serine by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-serine, an amino acid your body naturally produces and uses to build proteins and support nerve and brain function. The powder form lets you mix it into water or your favorite beverage.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Serine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Serine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Schizophrenia — rated "Possibly Effective" (Natural Medicines).

L-serine is possibly effective for schizophrenia based on available evidence. For Alzheimer disease, amyotrophic lateral sclerosis (ALS, also called Lou Gehrig's disease), back pain, post-traumatic stress disorder (PTSD), and general cognitive function, the evidence isn't strong enough yet to rate how well it works.

That doesn't mean it doesn't work — it means we don't have solid data in our monograph.

The evidence, ingredient by ingredient Serine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-serine is generally well tolerated at typical doses. The most common side effects are gastrointestinal — stomach pain, bloating, indigestion, nausea, and loss of appetite — and they tend to depend on how much you take.

At very high doses (above about 25 grams), rare serious effects like seizures and reversible eye movement problems have been reported. Supplement safety and long-term use aren't fully established, so talk to your doctor if you're taking it regularly.

Avoid L-serine during pregnancy and breastfeeding unless your doctor says it's okay — there isn't enough safety data in either situation.

Side effects, ingredient by ingredient Serine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for L-serine in our data.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

L-serine may be worth considering if you're exploring options for schizophrenia under professional guidance. If you're pregnant, breastfeeding, or taking any medications, check with your pharmacist first.

Start with a lower dose to see how your stomach handles it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Serine, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000L7Q831
Net contents 500 Gram(s); 17.6 Ounce(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 312271
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Serine by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2000 mg
Maximum serving Sizes:
2000 mg
Servings per container
250
UPC/BARCODE
X000L7Q831
IngredientAmount% DV
L-Serine2000 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BulkSupplements.com Clean & pure bulk supplements

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 2000 mg (about 3/4 tsp) once daily, or as directed by a physician.

General Statements

Use an accurate milligram scale.

New

Storage

Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

See for yourself

L-Serine by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Serine by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2000 mg Dosage formPowder Servings per container250 Amounts shown are per serving.

L-Serine

No known
interactions
2000 mg per serving

Serine is an amino acid your body can make on its own and also gets from protein-rich foods, so most people do not need a supplement. L-serine has bee...

L-Serine monograph & interactions
Interaction report

L-Serine by BulkSupplements.com Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Serine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Serine, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

L-Serine by BulkSupplements.com: Common Questions

Does L-Serine by BulkSupplements.com interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Serine. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Serine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does L-serine do in the body?
L-serine is an amino acid your body uses to build proteins and support nerve and brain cell function. Your body makes some on its own, but supplements add extra.
Is L-serine safe to take long-term?
Long-term safety isn't well established in studies. Stick with the labeled dose and talk to your pharmacist about how long you plan to use it, especially if side effects show up.
Can I take this while pregnant or breastfeeding?
No — there isn't enough safety data in pregnancy or breastfeeding. Avoid it unless your doctor specifically tells you it's okay.
What are the side effects?
The most common ones are stomach issues: pain, bloating, indigestion, nausea, and loss of appetite. These usually depend on how much you take. At very high doses, seizures have been reported, though that's rare.
Does L-serine actually improve memory or cognitive function?
The evidence in our data isn't strong enough yet to rate how well it works for memory or thinking. It's possibly effective for schizophrenia, but for cognitive function we just don't have solid proof either way.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Serine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Serine label
Go deeper

The Full Monographs Behind L-Serine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Serine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serine 3 references
  1. Fridman V, Suriyanarayanan S, Novak P, et al. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019;92(4):e359-e370.
  2. Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed
  3. Levine TD, Miller RG, Bradley WG, et al. Phase I clinical trial of safety of L-serine for ALS patients. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(1-2):107-111. PubMed

See these in context on the Serine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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