L-Threonine Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Threonine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Threonine is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for general amino acid/protein support, muscle and tissue health, immune support.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Threonine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Threonine by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Threonine by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Threonine by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-Threonine, an amino acid your body uses to build proteins and support nerve and immune function. The powder form lets you mix it into beverages or food.
There are no other inactive ingredients listed.
Does it work?
Couldn't assess
The evidence for L-Threonine on its own is limited. For amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), the data suggests it's likely ineffective.
For multiple sclerosis, familial spastic paraparesis, and spasticity, we don't have enough reliable evidence to say whether it works or not.
How safe is it?
Well-documented data
Threonine from food is well tolerated, but supplement use — especially at higher doses — hasn't been well studied. The most commonly reported side effects are headache and mild digestive upset, including diarrhea, gas, or constipation.
If you're pregnant or breastfeeding, the data isn't there to know whether supplemental threonine is safe, so talk with your doctor or pharmacist before taking it. Food amounts are normal and fine.
Meds to double-check
Major interaction found
Check with your doctor or pharmacist if you take any NMDA antagonist medications — this is a Major-severity interaction, and threonine may reduce how well these drugs work. The search tool below can help you confirm your exact medication.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.
L-Threonine is a single amino acid that may help with protein synthesis, but evidence for it on most neurological conditions is weak or absent. If you take an NMDA antagonist medication, you'll need to check with your own doctor or pharmacist before adding this supplement.
For most other situations, a conversation with your healthcare provider can help you decide if it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Threonine, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X000IOD0FV |
| Net contents | 1 kg; 35.3 oz |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2021 |
| DSLD ID | 252839 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Threonine by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Clean & pure bulk supplements
Formulation
Free of: Added sugar, soy, dairy, yeast, gluten, additives
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 2000 mg (about 3/4 tsp) once daily, or as directed by a physician.
Storage
Store in a dry, cool place
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Threonine by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Threonine by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2000 mg Dosage formPowder Servings per container500 Amounts shown are per serving.
L-Threonine
Interacts with3 drugs
Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a norma...
L-Threonine monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
L-Threonine by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
L-Threonine by BulkSupplements.com does interact with a category of medications called NMDA antagonists through a documented Major-severity interaction.
Threonine raises glycine levels in the brain, and glycine enhances the activity of NMDA receptors — so threonine may blunt how well these drugs work.
Read the full breakdown — every affected drug type, severity by severity
NMDA antagonists are used for various conditions including pain and neurological symptoms. If you take any medication in this class, check your exact drug name against the interaction tool below before starting L-Threonine.
Altogether, these interactions span 3 individual medications. Because this product contains only one active ingredient, you can now use the search box on this page to see which specific NMDA antagonists interact with it.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Threonine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Threonine interact with 3 drugs. Click any drug to see the details.
1 of the 1 ingredient in L-Threonine interact with drugs. Each result below shows which ingredient is responsible. L-Threonine
MemantineEbixa
How Memantine interacts with L-Threonine — through 1 ingredient. Tap an ingredient for the detail:
L-threonineNmda Antagonists Major
Interaction Summary
Theoretically, threonine might decrease the effects of NMDA antagonists.
Read the full L-threonine + Memantine interactionMemantine HydrochlorideNamenda
How Memantine Hydrochloride interacts with L-Threonine — through 1 ingredient. Tap an ingredient for the detail:
L-threonineNmda Antagonists Major
Interaction Summary
Theoretically, threonine might decrease the effects of NMDA antagonists.
Read the full L-threonine + Memantine Hydrochloride interactionMemantine, DonepezilNamzaric
How Memantine, Donepezil interacts with L-Threonine — through 1 ingredient. Tap an ingredient for the detail:
L-threonineNmda Antagonists Major
Interaction Summary
Theoretically, threonine might decrease the effects of NMDA antagonists.
Read the full L-threonine + Memantine, Donepezil interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Threonine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Threonine
Nmda Antagonists
Theoretically, threonine might decrease the effects of NMDA antagonists.
Threonine increases central nervous system (CNS) glycine levels. Glycine seems to bind a site on NMDA receptors and enhance the activity of the receptors.
Brand information
Manufacturer and brand details for L-Threonine, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
L-Threonine by BulkSupplements.com: Common Questions
Does L-Threonine by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take L-Threonine while pregnant or breastfeeding?
What are the side effects?
Does L-Threonine actually work for nerve or muscle conditions?
Why is this a single amino acid and not part of a protein blend?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Threonine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Threonine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Threonine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Threonine 4 references
- Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
- Lee A, Patterson V. A double blind study of L-threonine in patients with spinal spasticity. Acta Neurol Scand 1993;88:334-8. PubMed
- Blin O, Pouget J, Aubrespy G, et al. A double-blind placebo controlled trial of L-threonine in amyotrophic lateral sclerosis. J Neurol 1992;239:79-81.
- Roufs JB. L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS). Med Hypotheses 1991;34:20-3. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC