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Dietary supplement

Lobelia Ingredients & Drug Interactions

by Nature's Sunshine

Lobelia label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lobelia against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lobelia is a dietary supplement by Nature's Sunshine with 1 active ingredient. Its ingredients are commonly taken for asthma and breathing problems, cough and bronchitis, smoking cessation aid.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lobelia. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lobelia by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Lobelia by Nature's Sunshine — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lobelia by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Lobelia. It's a plant extract traditionally used in herbal medicine, though we'll cover what the science actually shows in the effectiveness section.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lobelia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: traditional respiratory support.
  • We looked for evidence on: Smoking cessation, asthma, bronchitis, cough.
  • The closest evidence on file: Lobelia is rated "Possibly Ineffective" for Smoking cessation (Natural Medicines).

For smoking cessation—the main use lobelia is marketed for—the evidence shows it is possibly ineffective. That means studies don't support that it helps people quit smoking.

The evidence, ingredient by ingredient Lobelia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lobelia carries real safety concerns. It can cause nausea, vomiting, diarrhea, coughing, dizziness, tremors, and throat irritation even at doses as low as 50 mg.

At higher doses—600 mg or more—it becomes toxic, causing sweating, rapid heartbeat (tachycardia), seizures, dangerously low body temperature (hypothermia), very low blood pressure (hypotension), coma, and death. The facts strongly caution that higher doses carry serious risk.

Avoid this product during pregnancy and while breastfeeding because of toxicity concerns and insufficient safety data.

Side effects, ingredient by ingredient Lobelia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lobelia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take lithium for mood disorders, check with your pharmacist before starting. Lobelia may increase lithium levels, and your dose might need adjustment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Lobelia isn't established as effective for smoking cessation. It carries real toxicity risk, especially at higher doses, and it's unsafe in pregnancy and breastfeeding.

If you take lithium, you'll need to check with your doctor or pharmacist before using this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lobelia, straight from the product label.

Brand Nature's Sunshine
Barcode (UPC) 099904004306
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 278157
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lobelia by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
099904004306
IngredientAmount% DV
Lobelia375 mg--

Other ingredients: Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Bottle made from 100% post consumer recycled material. We are committed to you and our planet. Scan to learn more.

We source the world's purest ingredients, no matter where they are grown, to ensure the active nutrients are delivered just as nature intended.

New look! Same great product

Precautions

Pregnant or lactating women should consult their health care professional prior to taking this supplement.

Do not use if inner seal is missing or damaged.

Seals/Symbols

Ko Pareve (Kosher)

Formula

Ko Pareve (Kosher)

Formulation

Traditional respiratory support

Guaranteed pure

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Natures Sunshine Herbal experts since 1972

Suggested/Recommended/Usage/Directions

Recommended Use: Take 1 capsule daily with a meal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lobelia by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lobelia label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lobelia by Nature's Sunshine

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Lobelia

Interacts with
1 drug
375 mg per serving

Lobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking...

Lobelia monograph & interactions

Other (inactive) ingredients: Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lobelia by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Lobelia?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Lobelia 1

Individual Drug Interactions

The ingredients in Lobelia interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Lobelia interact with drugs. Each result below shows which ingredient is responsible. Lobelia

Each ingredient & the kinds of drugs it affects

For each ingredient in Lobelia with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lobelia1 drug type · 1 drug

Lithium

Lobelia is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, lobelia might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Lobelia full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lobelia, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc.
City
Spanish Fork
State
UT
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Lobelia by Nature's Sunshine: Common Questions

Does Lobelia by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Lobelia has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lobelia contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does lobelia help you quit smoking?
The evidence shows it's possibly ineffective for smoking cessation. That's the main reason people use it, but studies don't support that it works.
What side effects does lobelia cause?
At low doses, it commonly causes nausea, vomiting, diarrhea, throat irritation, coughing, dizziness, and tremors—some people report these effects at doses as low as 50 mg. At high doses (600 mg or more), it becomes toxic and can cause seizures, rapid heartbeat, dangerously low blood pressure, and life-threatening effects.
Is it safe to take during pregnancy or while breastfeeding?
No. The safety data advises against use during pregnancy and breastfeeding because of toxicity concerns and lack of safety information.
Why is there a caution about higher doses?
Lobelia is toxic at high doses (600 mg or more) and can cause serious symptoms including seizures, rapid heartbeat, dangerously low blood pressure, coma, and death. That's why caution is strongly advised.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lobelia is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lobelia label
Go deeper

The Full Monographs Behind Lobelia’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lobelia

Interacts with 1 drug

Lobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking. It can be toxic in higher amounts, cau...

Read the full Lobelia monograph →
Sources

Sources & How We Checked

Lobelia's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lobelia 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. McChargue DE, Collins FL Jr, Cohen LM. Effect of non-nicotinic moist snuff replacement and lobeline on withdrawal symptoms during 48-h smokeless tobacco deprivation. Nicotine Tob Res 2002;4:195-200. PubMed
  5. Stead LF, Hughes JR. Lobeline for smoking cessation. Cochrane Database Syst Rev 2000;2:CD000124. PubMed
  6. Plakun, A. L., Ambrus, J., Bross, I., Graham, S., Levin, M. L., and Ross, C. A. Clinical factors in smoking withdrawal: preliminary report. Am J Public Health Nations.Health 1966;56(3):434-441. PubMed

See these in context on the Lobelia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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