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Dietary supplement

Ludent - Fluoride Chews 0.5 mg Ingredients & Drug Interactions

by Sancilio & Company

Ludent - Fluoride Chews 0.5 mg label
See full label image
Tablet Or Pill Category: Mineral
No known interaction
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ludent - Fluoride Chews 0.5 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Ludent - Fluoride Chews 0.5 mg is a dietary supplement by Sancilio & Company with 1 active ingredient. Its ingredients are commonly taken for preventing tooth decay (cavities), strengthening tooth enamel, dental care for children in low-fluoride areas.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

Jump to a section

HelloPharmacist Scorecard of Ludent - Fluoride Chews 0.5 mg by Sancilio & Company

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Ludent contains one active ingredient: fluoride at 0.5 mg per chew. Fluoride is a mineral that strengthens tooth enamel and helps prevent tooth decay.

The chew also contains several inactive ingredients — xylitol, microcrystalline cellulose, malic acid, magnesium stearate, talc, citric acid, natural orange flavor, and sucralose — which are fillers, binders, and flavorings that make up the tablet.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: prevent tooth decay and strengthen tooth enamel.
  • We looked for evidence on: Dental caries, Dental plaque, cavity prevention, enamel strengthening.
  • The strongest evidence on file: Fluoride is rated "Effective" for Dental caries (Natural Medicines).
  • Also on file: Fluoride is rated "Possibly Effective" for Dental plaque.

Fluoride is effective for preventing dental cavities (tooth decay). It's also possibly effective for strengthening bones (osteoporosis), reducing dental plaque buildup, and reducing gum inflammation (gingivitis), though the evidence for those uses is less established than for cavities.

The evidence, ingredient by ingredient Fluoride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Fluoride from this product is generally well tolerated at the recommended dose. The most common side effect when taken by mouth is mild stomach upset.

Rarely, some people have had allergic reactions — rashes, lip swelling, or mouth sores — though these are uncommon. The product is considered likely safe during pregnancy with normal dietary intake, but routine prenatal fluoride supplements aren't recommended; talk with your doctor about whether extra fluoride is right for you.

Important: fluoride in excess can cause fluorosis (tooth discoloration and enamel damage) and other harm, so stick to the recommended dose and be mindful of fluoride from other sources like toothpaste and drinking water.

Side effects, ingredient by ingredient Fluoride

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for the ingredients we could check. Feel free to use this product alongside your medications, but if you have any concerns, your doctor or pharmacist can review your specific regimen.

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Ludent is a straightforward fluoride chew for cavity prevention that works well for that purpose. It's a good fit if you want a convenient supplement to your regular oral care, especially if you don't get much fluoride from your water or toothpaste — but don't double up on fluoride sources without talking it over with your dentist or doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ludent - Fluoride Chews 0.5 mg, straight from the product label.

Brand Sancilio & Company
Barcode (UPC) 344946100999
Net contents 1000 Tablet(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 264162
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ludent - Fluoride Chews 0.5 mg by Sancilio & Company, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
1000
UPC/BARCODE
344946100999
IngredientAmount% DV
Fluoride0.5 mg--

Other ingredients: Xylitol, Microcrystalline Cellulose, Malic Acid, Magnesium Stearate, Talc, Citric Acid, natural Orange flavor, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

44946-1009-9

The numeric identifier on this product's labeling is an assigned product code for use with pharmacy-level, health-insurance and state level reimbursement programs and is not intended to denote registration with the FDA.

Formula

Sodium Fluoride chewable tablets

Contains Xylitol

Formulation

No dyes, artificial flavors or sugar Saccharin and gluten free

Description: White to off-white, orange flavor, round-shaped chewable tablet debossed "SCI" on one side and "1007" on the other.

FDA Statement of Identity

Dietary Supplement

Precautions

Dispense under a physician's order

Warning: Keep this product out of the reach of children.

If overdosage is suspected, seek professional assistance or contact a poison control center immediately 1-800-222-1222. Tablet should be chewed.

This product, as with all chewable tablets, is not recommended for children under age 4 due to risk of choking.

Do not use if foil seal under cap is broken or missing

Caution: Do not use this product if you are allergic to any of the ingredients.

Take this product at least 2 hours before or after taking any products containing calcium (including milk, yogurt, other dairy products) or aluminum/magnesium hydroxide (e.g., certain antacids/laxatives).

Prolonged daily ingestion of excessive fluoride may result in varying degrees of dental fluorosis. Account for all daily sources of fluoride intake.

The manufacturer of this product requires that it be dispensed only under the order of a physician or licensed medical practitioner.

Suggested/Recommended/Usage/Directions

Tablet should be chewed.

Directions: Use as directed by your physician.

Storage

Storage: Store in a cool, dry place at room temperature 20 degrees - 25 degrees C (68 degrees - 77 degrees F) away from heat and sunlight. Store in original container.

Seals/Symbols

Made in the USA

Brand IP Statement(s)

SCI Sancilio & Company, Inc. Developing Good Science into Great Medicine

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ludent - Fluoride Chews 0.5 mg by Sancilio & Company label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ludent - Fluoride Chews 0.5 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ludent - Fluoride Chews 0.5 mg by Sancilio & Company

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container1000 Amounts shown are per serving.

Fluoride

No known
interactions
0.5 mg per serving Form: Sodium Fluoride

Fluoride is a mineral best known for preventing cavities and strengthening tooth enamel, and it is widely used in toothpaste, mouth rinses, and commun...

Fluoride monograph & interactions

Other (inactive) ingredients: Xylitol, Microcrystalline Cellulose, Malic Acid, Magnesium Stearate, Talc, Citric Acid, Natural Orange flavor, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ludent - Fluoride Chews 0.5 mg by Sancilio & Company Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Ludent - Fluoride Chews 0.5 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Ludent - Fluoride Chews 0.5 mg, from the product label.

Sancilio & Company

See all Sancilio & Company products
Name
Sancilio & Company, Inc.
Street Address
3874 Fiscal Court
City
Riviera Beach
State
FL
ZipCode
33404
Phone Number
(800) 724-8711
Pharmacist Counseling Corner

Ludent - Fluoride Chews 0.5 mg by Sancilio & Company: Common Questions

Does Ludent - Fluoride Chews 0.5 mg by Sancilio & Company interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Ludent - Fluoride Chews 0.5 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Ludent - Fluoride Chews 0.5 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is fluoride safe at the dose in this product?
Yes, fluoride is safe at the recommended dental dose in this chew. The key is not to overdo it — excess fluoride from combining multiple sources (like chews, toothpaste, and fluoridated water) can cause fluorosis. Stick to the label dose and be aware of your total fluoride intake.
Can I take this if I'm pregnant or breastfeeding?
The data shows fluoride is likely safe during pregnancy with normal dietary intake, but possibly unsafe if you're taking extra supplements. Routine prenatal fluoride supplements aren't recommended — you and your baby get enough from food and water. Talk with your doctor about whether a supplement makes sense for you.
What does fluoride actually do?
Fluoride strengthens tooth enamel and prevents cavities — that's its proven use. It may also help with bone strength, reducing plaque buildup, and gum health, though the evidence for those isn't as solid.
Are there any side effects?
Most people have no side effects. Mild stomach upset is the most common when taken by mouth. Rarely, allergic reactions can happen — rashes, lip swelling, or mouth sores. If you notice any of those, stop and tell your doctor.
Does this product have fillers or other ingredients?
Yes — the chew contains xylitol, microcrystalline cellulose, malic acid, magnesium stearate, talc, citric acid, natural orange flavor, and sucralose as inactive ingredients. These are there to make the tablet, flavor it, and keep it stable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ludent - Fluoride Chews 0.5 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ludent - Fluoride Chews 0.5 mg label
Go deeper

The Full Monographs Behind Ludent - Fluoride Chews 0.5 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fluoride

Fluoride is a mineral best known for preventing cavities and strengthening tooth enamel, and it is widely used in toothpaste, mouth rinses, and community water. Supplements (drops or tablets...

Read the full Fluoride monograph →
Sources

Sources & How We Checked

Ludent - Fluoride Chews 0.5 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 39 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fluoride 39 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1999. Available at: http://books.nap.edu/books/0309063507/html/index.html.
  3. Position of the American Dietetic Association: the impact of fluoride on health. J Am Diet Assoc 2001;101:126-32.. PubMed
  4. Brown JP, Josse RG, et al. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 2002;167:S1-S34..
  5. Haguenauer D, Welch V, Shea B, et al. Fluoride for treating postmenopausal osteoporosis.(Cochrane Review). Cochrane Database Syst Rev 2002;(4):CD002825.. PubMed
  6. Choi AL, Sun G, Zhang Y, Grandjean P. Developmental fluoride neurotoxicity: a systematic review and meta-analysis. Environ Health Perspect. 2012 Oct;120(10):1362-8. PubMed
  7. Enamandram M, Das S, Chaney KS. Cheilitis and urticaria associated with stannous fluoride in toothpaste. J Am Acad Dermatol. 2014 Sep;71(3):e75-6. PubMed
  8. Foti C, Romita P, Ficco D, Bonamonte D, Angelini G. Allergic contact cheilitis to amine fluoride in a toothpaste. Dermatitis. 2014 Jul-Aug;25(4):209. PubMed
  9. Grey A, Garg S, Dray M, Purvis L, Horne A, Callon K, Gamble G, Bolland M, Reid IR, Cundy T. Low-dose fluoride in postmenopausal women: a randomized controlled trial. J Clin Endocrinol Metab. 2013 Jun;98(6):2301-7. PubMed
  10. Peters P, Drummond C. Perioral dermatitis from high fluoride dentifrice: a case report and review of literature. Aust Dent J. 2013 Sep;58(3):371-2. PubMed
  11. Sälzer S, Slot DE, Dörfer CE, Van der Weijden GA. Comparison of triclosan and stannous fluoride dentifrices on parameters of gingival inflammation and plaque scores: a systematic review and meta-analysis. Int J Dent Hyg. 2015 Feb;13(1):1-17.
  12. Till C, Green R, Flora D, et al. Fluoride exposure from infant formula and child IQ in a Canadian birth cohort. Environ Int. 2020;134:105315. PubMed
  13. Seddek AL, Ghallab A. Fluoride: No evidence of developmental neurotoxicity due to current exposure levels in Europe. Arch Toxicol. 2020;94(7):2543-2544. PubMed
  14. Green R, Lanphear B, Hornung R, et al. Association between maternal fluoride exposure during pregnancy and IQ scores in offspring in Canada. JAMA Pediatr. 2019;173(10):940-8. PubMed
  15. Guth S, Hüser S, Roth A, et al. Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses. Arch Toxicol. 2020;94(5):1375-1415. PubMed
  16. Canadian Dental Association. CDA position on use of fluorides in caries prevention. March 2012. Available at: https://www.cda-adc.ca/_files/position_statements/fluoride.pdf. Accessed December 9, 2020.
  17. Bellinger DC. Is fluoride potentially neurotoxic? JAMA Pediatr. 2019. PubMed
  18. Till C, Green R, Lanphear B. Association between maternal fluoride exposure and child IQ-reply. JAMA Pediatr. 2020;174(2):216-217. PubMed
  19. Bledsoe J, Breiger D, McKeever J. Association between maternal fluoride exposure and child IQ. JAMA Pediatr. 2020;174(2):213. PubMed
  20. Gong CX, James NE. Association between maternal fluoride exposure and child IQ. JAMA Pediatr. 2020;174(2):212-213. PubMed
  21. Bashash M, Marchand M, Hu H, et al. Prenatal fluoride exposure and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12?years of age in Mexico City. Environ Int. 2018;121(Pt 1):658-666. PubMed
  22. Riddell JK, Malin AJ, Flora D, McCague H, Till C. Association of water fluoride and urinary fluoride concentrations with attention deficit hyperactivity disorder in Canadian youth. Environ Int. 2019;133(Pt B):105190. PubMed
  23. Wei Y, Zhu J, Wetzstein SA. Plasma and water fluoride levels and hyperuricemia among adolescents: A cross-sectional study of a nationally representative sample of the United States for 2013-2016. Ecotoxicol Environ Saf 2021;208:111670. PubMed
  24. Davoudi M, Barjasteh-Askari F, Sarmadi M, et al. Relationship of fluoride in drinking water with blood pressure and essential hypertension prevalence: a systematic review and meta-analysis. Int Arch Occup Environ Health 2021;94(6):1137-1146. PubMed
  25. Veneri F, Vinceti M, Generali L, et al. Fluoride exposure and cognitive neurodevelopment: Systematic review and dose-response meta-analysis. Environ Res 2023;221:115239. PubMed
  26. Iamandii I, De Pasquale L, Giannone ME, et al. Does fluoride exposure affect thyroid function? A systematic review and dose-response meta-analysis. Environ Res 2024;242:117759. PubMed
  27. Mou Y, Qu T, Wang R, Zhang Y, He Z, Gu S. The association of high-fluoride and high-iodine combined exposure with dental fluorosis and goiter: a meta-analysis. Environ Geochem Health 2023;45(6):3143-3153. PubMed
  28. Hall M, Lanphear B, Chevrier J, Hornung R, Green R, Goodman C, et al. Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort. Sci Total Environ 2023;869:161149. PubMed
  29. Malin AJ, Riddell J, McCague H, Till C. Fluoride exposure and thyroid function among adults living in Canada: Effect modification by iodine status. Environ Int 2018;121(Pt 1):667-674. PubMed
  30. Do LG, Sawyer A, John Spencer A, et al. Early Childhood Exposures to Fluorides and Cognitive Neurodevelopment: A Population-Based Longitudinal Study. J Dent Res 2024; Dec. PubMed
  31. Do LG, Spencer AJ, Sawyer A, et al. Early Childhood Exposures to Fluorides and Child Behavioral Development and Executive Function: A Population-Based Longitudinal Study. J Dent Res 2023;102(1):28-36. PubMed
  32. Farmus L, Till C, Green R, et al. Critical windows of fluoride neurotoxicity in Canadian children. Environ Res 2021;200:111315. PubMed
  33. Grandjean P, Meddis A, Nielsen F, et al. Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies. Eur J Public Health 2024;34(1):143-149. PubMed
  34. Griebel-Thompson AK, Sands S, Chollet-Hinton L, et al. A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment. Adv Nutr 2023;14(2):317-338. PubMed
  35. Kumar JV, Moss ME, Liu H, Fisher-Owens S. Association between low fluoride exposure and children's intelligence: a meta-analysis relevant to community water fluoridation. Public Health 2023;219:73-84. PubMed
  36. Levy SM. Caution Needed in Interpreting the Evidence Base on Fluoride and IQ. JAMA Pediatr 2025. PubMed
  37. Taylor KW, Eftim SE, Sibrizzi CA, et al. Fluoride Exposure and Children's IQ Scores: A Systematic Review and Meta-Analysis. JAMA Pediatr 2025. PubMed
  38. Goodman CV, Hall M, Green R, et al. Iodine Status Modifies the Association between Fluoride Exposure in Pregnancy and Preschool Boys' Intelligence. Nutrients 2022;14(14):2920. PubMed
  39. Castiblanco-Rubio GA, Muñoz-Rocha TV, Téllez-Rojo MM, et al. Dietary Influences on Urinary Fluoride over the Course of Pregnancy and at One-Year Postpartum. Biol Trace Elem Res 2022;200(4):1568-1579. PubMed

See these in context on the Fluoride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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