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Dietary supplement

Lyophilized Liver Extract Ingredients & Drug Interactions

by Cardiovascular Research

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
The interaction bottom line Most serious interaction: Minor

Lyophilized Liver Extract is a dietary supplement by Cardiovascular Research with 1 active ingredient. Its ingredients are commonly taken for anemia and low iron, vitamin b12 support, general energy and fatigue.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Liver Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Lyophilized Liver Extract by Cardiovascular Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: liver extract (lyophilized, meaning freeze-dried). Liver extract is used as a nutritional supplement derived from animal liver.

The capsule itself is made from gelatin and glycerine, which are inactive ingredients that form and fill the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Liver Extract product and its label doesn't state a use — see Liver Extract's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on liver extract is mixed. For chronic fatigue syndrome, the data suggests it's possibly ineffective.

For hepatitis C, we don't have enough reliable evidence to rate whether it works or not. If you're considering this product for either of those conditions, talk it over with your doctor about what the current evidence supports.

The evidence, ingredient by ingredient Liver Extract

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

No adverse reactions have been formally reported, but we want to be straight with you: a thorough safety evaluation hasn't been conducted. Liver extract can deliver very high levels of vitamin A and iron, so it's not risk-free, especially at high doses or with long-term use.

There's also concern about product quality and source—liver extract comes from raw animal liver from slaughterhouses, which could potentially be contaminated or come from sick animals. In countries where bovine spongiform encephalitis (BSE, a serious brain disease in cattle) has been reported—including Great Britain, France, The Netherlands, Portugal, Luxembourg, Ireland, Switzerland, Oman, and Belgium—there is theoretical concern about contaminated tissue, though no human cases from liver extract have been reported.

If you're pregnant, this product delivers high vitamin A, which could harm a developing baby; avoid it unless your doctor advises otherwise. If you're breastfeeding or considering this during pregnancy, there isn't enough safety data on file—talk with your doctor for personalized advice.

Side effects, ingredient by ingredient Liver Extract

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Liver Extract.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any blood thinner, flag this product—starting or stopping it could theoretically shift how well the blood thinner works. Also double-check if you're on iron-containing medications or supplements; combining them with this product may increase iron levels in your body.

Run your exact medications through the checker before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Lyophilized Liver Extract is generally low-risk for healthy adults at food amounts, but it concentrates vitamin A and iron, which matters if you're taking blood thinners like warfarin or iron supplements. Product sourcing and safety studies are limited, so this is a conversation-with-your-doctor kind of supplement rather than a grab-and-go one.

Before you start, check your exact medications with the tool on this page and run the decision past your own doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lyophilized Liver Extract, straight from the product label.

Brand Cardiovascular Research
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22720
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lyophilized Liver Extract by Cardiovascular Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
90
IngredientAmount% DV
Liver Extract550 mg--

Other ingredients: Gelatin, Glycerine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

The nutrients contained within these capsules are the purest and highest quality obtainable and contain no fillers, binders, excipients, flow agents or preservatives to insure maximal tolerance and absorption.

FDA Disclaimer Statement

This product has not been evaluated by the FDA. This product is not intended to diagnose, cure, treat or prevent any disease.

Seals/Symbols

ECOLOGICAL FORMULAS

FDA Statement of Identity

Dietary Supplement

A DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS Take three capsules daily, or as directed by a physician.

General Statements

11010328

Lyophilized Liver Extract is a specially prepared nutritional supplement derived from organically-grazed cattle and contains absolutely no trace of pesticides or synthetic hormones. Prior to extraction, the liver is lyophilized (freeze-dried) to protect the delicate nucleoproteins and polypeptides from denaturation. Then it is subject to hydrolysis to extract a high concentration of Superoxide dismutase and Catalase. These nutrients are potent antioxidants and serve as a support to liver function.

See for yourself

Lyophilized Liver Extract by Cardiovascular Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Lyophilized Liver Extract by Cardiovascular Research

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Liver Extract

Interacts with
3 drugs
550 mg per serving

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once...

Liver Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lyophilized Liver Extract by Cardiovascular Research Drug Interactions

Want to check YOUR meds against Lyophilized Liver Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
3Drugs
3 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Lyophilized Liver Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Liver Extract2 drug types · 3 drugs

Iron

Liver extract can contain heme iron. Taking liver extract with iron-containing medications or supplements may increase total iron intake and could increase the risk of gastrointestinal adverse effects or excessive iron accumulation. The risk is greater with high doses, prolonged use, or in individuals with hemochromatosis or another iron-overload disorder. Review the iron content of the liver extract and the total elemental iron dose. Avoid unnecessary duplicate iron supplementation and consider monitoring ferritin and transferrin saturation when clinically appropriate.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Liver extract products may contain small and variable amounts of vitamin K. Theoretically, starting, stopping, or substantially changing the amount of liver extract used could reduce the anticoagulant effect of warfarin and lower the INR. However, this interaction has not been directly studied or reported in humans, and the vitamin K content of liver extract products is generally not standardized. Consider monitoring the INR after a meaningful change in liver extract use.

Likelihood Possible Evidence C
The maker

Brand information

Manufacturer and brand details for Lyophilized Liver Extract, from the product label.

Cardiovascular Research

See all Cardiovascular Research products
Name
CARDIOVASCULAR RESEARCH, LTD.
Street Address
1061-B SHARY CIRCLE
City
CONCORD
State
CA
ZipCode
94518
Pharmacist Counseling Corner

Lyophilized Liver Extract by Cardiovascular Research: Common Questions

Does Lyophilized Liver Extract by Cardiovascular Research interact with any medications?
Yes. Based on its ingredients, Lyophilized Liver Extract has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lyophilized Liver Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is liver extract safe during pregnancy?
No. Liver extract can deliver very high amounts of vitamin A, which may harm a developing baby. The safety data advises against it unless your doctor specifically tells you it's okay. Talk with your doctor before taking it if you're pregnant or planning to become pregnant.
What exactly is in this capsule?
One active ingredient—freeze-dried liver extract—plus gelatin and glycerine to make the capsule. That's it. The liver extract itself comes from animal liver and can contain vitamin K, iron, and vitamin A.
Does this actually work for chronic fatigue?
Not according to the evidence we have. For chronic fatigue syndrome, liver extract is rated possibly ineffective. If that's why you're looking at it, your doctor can help you explore what might actually help.
Can I take this with my iron supplement?
Not without checking first. Liver extract contains heme iron, so adding it on top of an iron supplement raises your total iron intake and could cause stomach problems or excess iron to build up, especially over time or at high doses. Talk with your pharmacist or doctor before combining them.
What are the side effects?
No adverse reactions have been formally reported, but a thorough safety study hasn't been done either. The bigger concern is that liver extract concentrates vitamin A and iron, which can cause problems at high doses or with long-term use—especially if you have a condition like iron overload or are pregnant.
Where does the liver come from, and is it safe?
Liver extract comes from raw animal liver from slaughterhouses, which raises questions about source quality and potential contamination. In countries where BSE (a serious brain disease in cattle) has been reported, there's theoretical concern, though no human cases from liver extract have been documented. If source and purity matter to you, ask the manufacturer where their liver is sourced.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lyophilized Liver Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lyophilized Liver Extract label
Go deeper

The Full Monographs Behind Lyophilized Liver Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Lyophilized Liver Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Liver Extract 4 references
  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
  3. Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
  4. Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed

See these in context on the Liver Extract monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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