Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Mega Benfotiamine 250 mg Ingredients & Drug Interactions

by Life Extension

Mega Benfotiamine 250 mg label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mega Benfotiamine 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Mega Benfotiamine 250 mg is a dietary supplement by Life Extension with 2 active ingredients. Its ingredients are commonly taken for preventing or treating thiamine deficiency, beriberi, wernicke-korsakoff syndrome (alcohol-related).Based on those ingredients, 3 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Thiamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mega Benfotiamine 250 mg by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Mega Benfotiamine 250 mg by Life Extension — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Mega Benfotiamine 250 mg by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: thiamine and benfotiamine. Thiamine (also called vitamin B1) is an essential nutrient your body uses for energy and nerve function.

Benfotiamine is a fat-soluble form of thiamine that may be absorbed differently and is sometimes studied for nerve-related conditions. The capsule also contains inactive ingredients — microcrystalline cellulose, cellulose, silica, and stearate — which are fillers and binders that hold the supplement together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Thiamine deficiency — rated "Effective" (Thiamine) (Natural Medicines).
  • On file: Wernicke-Korsakoff syndrome (WKS) — rated "Effective" (Thiamine) (Natural Medicines).
  • On file: Dysmenorrhea — rated "Possibly Effective" (Thiamine) (Natural Medicines).
  • On file: Diabetic neuropathy — rated "Possibly Effective" (Benfotiamine) (Natural Medicines).

Thiamine is effective for treating thiamine deficiency and Wernicke-Korsakoff syndrome, a serious neurological condition linked to severe thiamine lack. It's possibly effective for period pain (dysmenorrhea), though the evidence is weaker.

For heart failure and as a mosquito repellent, it's rated possibly ineffective. Benfotiamine is possibly effective for nerve damage caused by diabetes (diabetic neuropathy).

For other conditions — including diabetic kidney damage, Alzheimer disease, and general peripheral nerve pain — the evidence is either insufficient or suggests it's possibly ineffective. The long-term benefits and safety of benfotiamine aren't fully established.

The evidence, ingredient by ingredient Thiamine Benfotiamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Thiamine is generally very safe when taken by mouth in normal amounts. Rarely, it may cause skin allergies or other allergic reactions — and very rarely, when given by injection, it can trigger serious allergic responses.

Thiamine is needed during pregnancy and breastfeeding, but use supplement doses only as advised by your doctor or pharmacist. Benfotiamine is generally well tolerated in short-term studies, though long-term safety isn't fully known.

In one trial, a small number of participants reported mild skin allergies or slight stomach discomfort, but these rates were no different from placebo. There isn't enough safety data on benfotiamine during breastfeeding, so talk with your doctor before using it if you're nursing.

Side effects, ingredient by ingredient Thiamine Benfotiamine

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Thiamine.
  • The most serious interaction on file is rated Minor.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take trimethoprim (Proloprim), let your pharmacist know before using this product — it may raise your thiamine levels. No other interactions are documented for the ingredients we could check, but your exact medication list matters, so use the search tool below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.

This product is a straightforward option if you're looking to address a thiamine deficiency or want to try benfotiamine for diabetic nerve damage — thiamine's track record is solid. If you're pregnant or breastfeeding, or if you take trimethoprim, check with your pharmacist first.

Otherwise, run your medications through the interaction checker on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mega Benfotiamine 250 mg, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870925125
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 328567
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mega Benfotiamine 250 mg by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
120
UPC/BARCODE
737870925125
IngredientAmount% DV
Thiamine10 mg833%
Benfotiamine250 mg--

Other ingredients: Microcrystalline Cellulose, Cellulose, Silica, Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Precautions

Read the entire label and follow the directions carefully.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is damaged.

Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule one to four times daily, or as recommended by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

Formulation

Gluten free Non GMO LE Certified

Seals/Symbols

Non GMO LE Certified

Formula

Fat & water soluble vitamin B1

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mega Benfotiamine 250 mg by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mega Benfotiamine 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mega Benfotiamine 250 mg by Life Extension

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Thiamine

Interacts with
3 drugs
10 mg per serving Form: Thiamine Hydrochloride, Vitamin B1

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

Benfotiamine

No known
interactions
250 mg per serving

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...

Benfotiamine monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Cellulose, Silica, Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mega Benfotiamine 250 mg by Life Extension Drug Interactions

Want to check YOUR meds against Mega Benfotiamine 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Minor

Ingredients driving the most interactions

Thiamine 3

Individual Drug Interactions

The ingredients in Mega Benfotiamine 250 mg interact with 3 drugs. Click any drug to see the details.

1 of the 2 ingredients in Mega Benfotiamine 250 mg interact with drugs. Each result below shows which ingredient is responsible. Thiamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Mega Benfotiamine 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mega Benfotiamine 250 mg, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Mega Benfotiamine 250 mg by Life Extension: Common Questions

Does Mega Benfotiamine 250 mg by Life Extension interact with any medications?
Yes. Based on its ingredients, Mega Benfotiamine 250 mg has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mega Benfotiamine 250 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is thiamine the same thing as benfotiamine?
Both are forms of vitamin B1, but they're not identical. Thiamine is the standard form; benfotiamine is a fat-soluble version that some research suggests may be absorbed better and used differently in the body. This product includes both.
Can I take this if I'm pregnant?
Thiamine is rated likely safe and is actually needed during pregnancy — your body requires it. Use supplement doses only as your doctor advises. For benfotiamine, there isn't enough safety information during pregnancy, so talk with your provider about whether it's right for you.
What does this do for nerve pain?
Benfotiamine is possibly effective for nerve damage caused by diabetes. For other types of nerve pain, the evidence isn't strong enough yet. If you're dealing with neuropathy, your doctor can help you figure out whether this is worth trying.
Are there any side effects?
Thiamine is very safe in normal amounts — allergic reactions are rare. With benfotiamine, a small number of people in trials reported mild skin allergies or slight stomach upset, but these were no more common than with placebo. Most people tolerate it well.
Is this safe to take long-term?
Thiamine has a long safety track record. For benfotiamine, the long-term safety picture isn't fully worked out yet because most studies are short. Your pharmacist or doctor can advise whether ongoing use makes sense for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mega Benfotiamine 250 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mega Benfotiamine 250 mg label
Go deeper

The Full Monographs Behind Mega Benfotiamine 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph → Herb & supplement monograph

Benfotiamine

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied for diabetic nerve problems, but the ev...

Read the full Benfotiamine monograph →
Sources

Sources & How We Checked

Mega Benfotiamine 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thiamine 7 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
  7. Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

See these in context on the Thiamine monograph →

Benfotiamine 1 reference
  1. Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116(10):600-5. PubMed

See these in context on the Benfotiamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team