Interactions on record — worth a quick check against your medications. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

Menopausal Formula Ingredients & Drug Interactions

by Wonder Laboratories

Menopausal Formula label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Menopausal Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Menopausal Formula is a dietary supplement by Wonder Laboratories with 8 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 1,150 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E, Black Cohosh extract, Horse Chestnut extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Menopausal Formula by Wonder Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Menopausal Formula by Wonder Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Menopausal Formula by Wonder Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Wonder Laboratories' Menopausal Formula has 8 active ingredients: vitamin E, boron, Korean ginseng, black cohosh extract, Mexican wild yam, chaste tree, horse chestnut extract, and soy germ isoflavone concentrate. Vitamin E is a fat-soluble antioxidant; boron supports bone and mineral metabolism; black cohosh and chaste tree are herbal adaptogens traditionally used for hormonal support; Mexican wild yam and soy isoflavones are plant-based sources of phytoestrogens (plant compounds mimicking estrogen); and horse chestnut supports vascular function.

The capsules also contain inactive ingredients: gelatin, cellulose, silica, and magnesium stearate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support for menopausal symptoms and women's health.
  • We looked for evidence on: Menopausal symptoms, Dysmenorrhea, Mastalgia, Amenorrhea, Breast cancer-related hot flashes, hot flashes — and 2 related terms.
  • The strongest evidence on file: Black Cohosh is rated "Possibly Effective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Vitamin E is rated "Possibly Effective" for Dysmenorrhea.
  • Also on file: Vitex Agnus-castus is rated "Possibly Effective" for Mastalgia.

For menopausal symptoms specifically—the condition this formula is designed for—black cohosh is rated possibly effective, while Mexican wild yam is rated possibly ineffective. Chaste tree is rated possibly effective for premenstrual syndrome and breast tenderness, conditions that sometimes overlap with menopause.

Vitamin E is effective for true vitamin E deficiency and possibly effective for Alzheimer disease and a few rare genetic conditions, but those uses don't match a menopausal symptom profile. We have no effectiveness data on file for Korean ginseng or soy germ isoflavones in this product.

The evidence, ingredient by ingredient Vitamin E Boron Black Cohosh Wild Yam Vitex Agnus-castus Horse Chestnut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E is generally well tolerated at dietary amounts, but high-dose long-term supplements may raise bleeding risk and other harms; avoid high-dose supplements in pregnancy unless your doctor directs otherwise, and check with your doctor before high doses while breastfeeding. Boron is generally safe in small amounts but high doses can be toxic; avoid supplemental boron in pregnancy and while breastfeeding due to limited data.

Black cohosh is generally well tolerated short-term but rare liver concerns mean medical guidance is wise; avoid it in pregnancy and while breastfeeding because safety data is sparse and possible effects on the uterus raise concerns. Mexican wild yam is likely fine short-term but long-term safety isn't well studied; avoid in pregnancy and while breastfeeding.

Chaste tree is often well tolerated short-term but may affect hormones, so use under guidance; avoid in pregnancy and while breastfeeding due to possible hormonal effects. Horse chestnut seed extract (properly processed) is reasonably well tolerated, but raw plant parts are toxic; avoid in pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Vitamin E Boron Black Cohosh Wild Yam Vitex Agnus-castus Horse Chestnut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Black Cohosh, Vitamin E, Vitex Agnus-castus, Wild Yam, Horse Chestnut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments.
  • For scale: 1,151 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this supplement, check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel)—vitamin E and horse chestnut may raise bleeding risk. Also double-check if you take oral contraceptives, estrogen therapy, antipsychotic drugs, dopamine agonists, metoclopramide, serotonergic drugs (like antidepressants), chemotherapy, cyclosporine, or drugs processed by your liver's CYP2D6 or CYP3A4 enzymes.

Because we couldn't check Korean ginseng or soy germ isoflavones, mention those ingredients to your pharmacist too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This formula targets menopausal symptoms with a mix of herbal and nutrient ingredients—some with modest evidence (black cohosh, chaste tree) and others with little or none. The biggest concern is bleeding risk, especially if you're on blood thinners or take aspirin.

If you take any prescription medication—particularly blood thinners, oral contraceptives, antipsychotics, estrogen therapy, or chemotherapy—talk with your doctor or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Menopausal Formula, straight from the product label.

Brand Wonder Laboratories
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 262132
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Approved Health, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Menopause, Seniors/Mature (>50 Years) - Women ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Menopausal Formula by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
IngredientAmount% DV
Vitamin E400 IU1333%
Boron1.5 mg--
Korean Ginseng50 mg--
Black Cohosh extract80 mg--
Mexican Wild Yam50 mg--
Chaste Tree50 mg--
Horse Chestnut extract50 mg--
Soy Germ Isoflavone Concentrate700 mg--

Other ingredients: Gelatin, Vegetable Cellulose, Silica, Vegetable Magnesium Stearate, Vegetable Magnesium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 2 capsules two times daily, preferably with a meal.

Formulation

Black Cohosh is among the world's most popular herbs for women. This native American herb has been used for centuries for supporting women's health and has now been scientifically researched for its beneficial effects during menopause. It has found widespread use and official recognition in European countries and is now becoming the worldwide herb of choice for women seeking a natural approach to mid-life changes.

Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs) Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Nutritional support during menopause

Made in USA

Formula

This assured potency formulation uses Black Cohosh Extract (standardized to contain 2.5% total Triterpene glycosides, 2 mg), Soy Germ Isoflavone Concentrate (standardized to contain 3% Isoflavones, 21 mg), Korean Ginseng (Panax Ginseng, 2.5 mg) Extract (standardized to contain 5% Ginsenosides), and Mexican Wild Yam 10:1 Extract.

Black cohosh

Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Caution: If you are pregnant or nursing, consult your physician before taking this product.

Keep out of reach of children.

Contains soy ingredients.

Storage

Keep tightly closed. Store at room temperature: 59 degrees-86 degrees F (15 degrees-30 degrees C).

General Statements

Formula 371

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Menopausal Formula by Wonder Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Menopausal Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Menopausal Formula by Wonder Laboratories

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin E

Interacts with
764 drugs
400 IU per serving Form: D-Alpha-Tocopheryl Succinate

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Boron

No known
interactions
1.5 mg per serving

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence f...

Boron monograph & interactions

Korean Ginseng

50 mg per serving

Black Cohosh extract

Interacts with
652 drugs
80 mg per serving

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It...

Black Cohosh extract monograph & interactions

Mexican Wild Yam

Interacts with
41 drugs
50 mg per serving

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Mexican Wild Yam monograph & interactions

Chaste Tree

Interacts with
121 drugs
50 mg per serving

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS sympto...

Chaste Tree monograph & interactions

Horse Chestnut extract

Interacts with
122 drugs
50 mg per serving Form: Aescin

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and h...

Horse Chestnut extract monograph & interactions

Soy Germ Isoflavone Concentrate

700 mg per serving

Other (inactive) ingredients: Gelatin, Vegetable Cellulose, Silica, Vegetable Magnesium Stearate, Vegetable Magnesium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Menopausal Formula by Wonder Laboratories Drug Interactions

Want to check YOUR meds against Menopausal Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,150Drugs
1,141 Moderate 9 Minor

Ingredients driving the most interactions

Vitamin E 764
Black Cohosh extract 652
Horse Chestnut extract 122
Chaste Tree 121
Mexican Wild Yam 41

Individual Drug Interactions

The ingredients in Menopausal Formula interact with 1,150 drugs. Click any drug to see the details.

5 of the 8 ingredients in Menopausal Formula interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Black Cohosh extract Horse Chestnut extract Chaste Tree Mexican Wild Yam

Each ingredient & the kinds of drugs it affects

For each ingredient in Menopausal Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Black Cohosh extract7 drug types · 652 drugs

Atorvastatin (Lipitor)

Taking black cohosh with atorvastatin might increase the risk for elevated liver function tests.
In one case report, a patient taking atorvastatin (Lipitor) developed significantly elevated liver function enzymes after starting black cohosh 100 mg four times daily. Liver enzymes returned to normal when black cohosh was discontinued. It is unclear whether the elevated liver enzymes were due to black cohosh itself or an interaction between atorvastatin and black cohosh.

Likelihood Possible Evidence D
Cisplatin (Platinol-Aq)

Theoretically, black cohosh may reduce the clinical effects of cisplatin.
Animal research suggests that black cohosh might decrease the cytotoxic effect of cisplatin on breast cancer cells.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Some clinical research suggests that black cohosh might modestly inhibit CYP2D6 and increase levels of drugs metabolized by this enzyme. However, contradictory clinical research shows a specific black cohosh product (Remifemin, Enzymatic Therapy) 40 mg twice daily does not significantly inhibit metabolism of a CYP2D6 substrate in healthy study volunteers. Until more is known, use black cohosh cautiously in patients taking drugs metabolized by CYP2D6.

Likelihood Possible Evidence B
Estrogens

Theoretically, black cohosh may alter the effects of estrogen therapy.
Some research suggests that black cohosh has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
There is concern that black cohosh might be linked to cases of liver failure and autoimmune hepatitis.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.
Black cohosh might increase the risk of serotonin syndrome when combined with other serotonergic drugs. Black cohosh acts as an agonist at several serotonin receptor subtypes and might interact with other serotonergic medications. In one case, a 55-year-old female who had been on stable treatment with sertraline 50 mg and duloxetine 60 mg daily developed serotonin syndrome after taking black cohosh extract 40 mg daily for 3 days.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.
In vitro research shows that black cohosh modestly inhibits OATP2B1. OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Black Cohosh extract full monograph & interactions

Horse Chestnut extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Horse chestnut contains the constituent esculin which has been shown to have antithrombotic effects. Therefore, horse chestnut might have antiplatelet effects. This has not been shown in humans.

Likelihood Possible Evidence D
Horse Chestnut extract full monograph & interactions

Chaste Tree5 drug types · 121 drugs

Antipsychotic Drugs

Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.

Likelihood Possible Evidence B
Dopamine Agonists

Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.

Likelihood Probable Evidence D
Metoclopramide (Reglan)

Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.

Likelihood Possible Evidence D
Chaste Tree full monograph & interactions

Mexican Wild Yam1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Mexican Wild Yam full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Menopausal Formula, from the product label.

Wonder Laboratories

See all Wonder Laboratories products
Name
Wonder Laboratories
Street Address
115 S.C.T. Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Menopausal Formula by Wonder Laboratories: Common Questions

Does Menopausal Formula by Wonder Laboratories interact with any medications?
Yes. Based on its ingredients, Menopausal Formula has a known interaction with 1,150 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Menopausal Formula contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin or another blood thinner?
No—not without checking first. Vitamin E in this formula can increase bleeding risk with blood thinners, especially doses over 400 IU daily. Talk to your doctor or pharmacist before starting; they may need to adjust your dose or monitor you more closely.
Is this safe to take while pregnant?
No. Black cohosh, chaste tree, boron, and horse chestnut all carry "avoid" ratings in pregnancy due to insufficient safety data or possible harmful effects. Mexican wild yam and vitamin E have mixed or limited pregnancy data. Do not take this product while pregnant without your doctor's explicit guidance.
Can I take this while breastfeeding?
No. Black cohosh, chaste tree, boron, and horse chestnut should be avoided while breastfeeding because safety hasn't been established or there are specific concerns about milk-related hormones. Talk to your doctor or lactation specialist before use.
Does this actually work for hot flashes and night sweats?
Black cohosh in this formula is rated possibly effective for menopausal symptoms, which includes hot flashes. Chaste tree is possibly effective for breast tenderness, a related symptom. The other ingredients don't have strong evidence for menopausal symptom relief.
What is chaste tree and why is it in here?
Chaste tree (also called vitex) is an herbal ingredient traditionally used for hormonal balance. It's rated possibly effective for premenstrual syndrome and breast tenderness, which commonly occur alongside menopause. It works by affecting dopamine and may interact with some medications, so mention it when checking with your pharmacist.
What are phytoestrogens, and why are they in a menopausal formula?
Phytoestrogens are plant compounds that mimic estrogen in the body. Mexican wild yam and soy isoflavones in this formula contain them, and they're included because some people believe they can ease menopausal symptoms. However, wild yam is rated possibly ineffective for those symptoms, and the evidence for soy isn't established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Menopausal Formula label
Go deeper

The Full Monographs Behind Menopausal Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Black Cohosh

Interacts with 652 drugs

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It is generally well tolerated for short-t...

Read the full Black Cohosh monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph → Herb & supplement monograph

Vitex Agnus-castus

Interacts with 121 drugs

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...

Read the full Vitex Agnus-castus monograph → Herb & supplement monograph

Horse Chestnut

Interacts with 122 drugs

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and heaviness. Raw, unprocessed horse chestnu...

Read the full Horse Chestnut monograph →
Sources

Sources & How We Checked

Menopausal Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 189 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
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Boron 6 references
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Black Cohosh 68 references
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Wild Yam 7 references
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Vitex Agnus-castus 23 references
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Horse Chestnut 21 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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