Meta-Sitosterol 2.0 Ingredients & Drug Interactions
by Metagenics
What is this page for?
First and foremost: checking Meta-Sitosterol 2.0 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Meta-Sitosterol 2.0 is a dietary supplement by Metagenics with 6 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,025 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Meta-Sitosterol 2.0 by Metagenics
Ask about any prescription or over-the-counter medication and we check it for interactions with Meta-Sitosterol 2.0 by Metagenics — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Meta-Sitosterol 2.0 by Metagenics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Meta-Sitosterol 2.0 has 5 active ingredients: folate, beta-sitosterol, campesterol, stigmasterol, and other plant sterols. Beta-sitosterol and its related compounds are plant-derived sterols that support cholesterol metabolism and may help with benign prostate enlargement (BPH).
The product also contains inactive ingredients such as microcrystalline cellulose, croscarmellose sodium, and silica, which act as binders and flow agents in the tablet.
Does it work?
Strong evidence
Beta-sitosterol in this product is likely effective for benign prostatic hyperplasia (BPH) — the non-cancerous enlargement of the prostate that causes urinary symptoms. It is possibly effective for familial hypercholesterolemia (an inherited condition that raises cholesterol) and coronary heart disease (CHD).
We do not have effectiveness data on file for the other active ingredients in the product.
How safe is it?
Well-documented data
Beta-sitosterol is generally well tolerated when taken short-term by most adults. The most common side effects are constipation, diarrhea, gas, indigestion, and nausea.
There are isolated reports of reduced appetite and one case of acute pancreatitis associated with beta-sitosterol use, though symptoms resolved when the user stopped taking it. Beta-sitosterol may worsen acne in some people.
Because there is not enough safety data, it is best to avoid this product during pregnancy and while breastfeeding — talk with your doctor or pharmacist about personalized advice.
Meds to double-check
Moderate interaction found
No interactions are documented in our data for the ingredients we could check. However, we could not check folate, campesterol, stigmasterol, or other plant sterols.
If you take any medication — especially those affecting cholesterol, fat absorption, or blood clotting — confirm with your doctor or pharmacist before starting this product.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Meta-Sitosterol 2.0 is a reasonable choice if you're looking to support prostate health or cholesterol levels, since beta-sitosterol is likely effective for BPH. Expect mild digestive side effects like gas or loose stools in some cases.
If you're pregnant, nursing, or take blood thinners or cholesterol drugs, check with your doctor or pharmacist first — we cannot fully rule out interactions with ingredients we could not assess.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Meta-Sitosterol 2.0, straight from the product label.
| Brand | Metagenics |
|---|---|
| Barcode (UPC) | 755571910660 |
| Net contents | 90 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2023 |
| DSLD ID | 295795 |
| Product type | Fat/fatty Acid |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Meta-Sitosterol 2.0 by Metagenics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 0 NP, 1 Gram(s) | 1% |
| Folate | 445 mcg DFE, 1330 mcg DFE | 111%, 333% |
| Dietary Fiber | 0 NP, 1 Gram(s) | 3% |
| Beta-Sitosterol | 333 mg, 1000 mg | -- |
| Campesterol | 167 mg, 500 mg | -- |
| Stigmasterol | 92 mg, 275 mg | -- |
| Other Plant Sterols | 117 mg, 350 mg | -- |
Other ingredients: Plant Sterol Complex, Microcrystalline Cellulose, Croscarmellose Sodium, Cellulose, Stearic Acid, Silica, Calcium L-5-Methyltetrahydrofolate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Meta-Sitosterol 2.0 is a naturally derived vegetable preparation featuring enhanced levels of a balanced concentrate of plant sterols - 2 grams per day - which may help to maintain healthy blood levels already within the normal range. Also features the active, preferred form of folate (L-5-methyltetrahydrofolate) to support healthy homocysteine metabolism and cardiovascular health.
Plant sterol complex for support of healthy cholesterol levels
Formulation
The National Institute of Health recommends a healthy diet, along with the consumption of 2 grams of plant sterols daily, to promote cardiovascular health.
This gluten-free and vegetarian.
This gluten-free and vegetarian.
Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)
Suggested/Recommended/Usage/Directions
Directions: Take one tablet with each meal or as directed by your healthcare practitioner.
Precautions
Caution: Keep out of the reach of children.
Practitioner Exclusive
Contains: Soy.
Storage
Do not refrigerate (Refrigeration may cause moisture condensation)
Seals/Symbols
Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administrator. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
As Metafolin, Metafolin is a registered trademark of Merck KGaA, Darmstadt Germany.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Meta-Sitosterol 2.0 by Metagenics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Meta-Sitosterol 2.0 by Metagenics
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Folate
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactionsBeta-Sitosterol
No knowninteractions
Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Eviden...
Beta-Sitosterol monograph & interactionsCampesterol
Stigmasterol
Other Plant Sterols
Other (inactive) ingredients: Plant Sterol Complex, Microcrystalline Cellulose, Croscarmellose Sodium, Cellulose, Stearic Acid, Silica, Calcium L-5-Methyltetrahydrofolate. These complete the product’s ingredient list but are not active constituents.
Meta-Sitosterol 2.0 by Metagenics Drug Interactions
HelloPharmacist Interaction Report
Meta-Sitosterol 2.0 by Metagenics contains five active ingredients, but we have interaction data only for beta-sitosterol — and no interactions are documented in our data for that ingredient.
We cannot check folate, campesterol, stigmasterol, or other plant sterols because we hold no monographs for them.
Read the full breakdown — every affected drug type, severity by severity
Although no interactions are documented for the ingredients we could check, this is not a guarantee that none exist with your specific medications. Plant sterols can affect how your body processes certain lipids and nutrients, so if you take any prescription medication — especially cholesterol-lowering drugs, anticoagulants (blood thinners), or drugs that depend on fat absorption — run them through the checker on this page or talk with your doctor or pharmacist before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Meta-Sitosterol 2.0?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Meta-Sitosterol 2.0 interact with 2,025 drugs. Click any drug to see the details.
1 of the 6 ingredients in Meta-Sitosterol 2.0 interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber
Abiraterone
How Abiraterone interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acalabrutinib interactionAcamprosateCampral
How Acamprosate interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acamprosate interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Meta-Sitosterol 2.0 — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Meta-Sitosterol 2.0 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Brand information
Manufacturer and brand details for Meta-Sitosterol 2.0, from the product label.
Metagenics
See all Metagenics products- Name
- Metagenics
- City
- Gig Harbor
- State
- WA
- ZipCode
- 98332
- Phone Number
- 800 692 9400
- Web Address
- metagenics.com
Meta-Sitosterol 2.0 by Metagenics: Common Questions
Does Meta-Sitosterol 2.0 by Metagenics interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does beta-sitosterol really help with an enlarged prostate?
Will this help my cholesterol?
What side effects should I expect?
Can I take this while pregnant or breastfeeding?
What's folate doing in here?
Are the other plant sterols (campesterol, stigmasterol) as well-studied as beta-sitosterol?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Meta-Sitosterol 2.0 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Meta-Sitosterol 2.0’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographBeta-sitosterol
Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Evidence is moderate for these uses and weaker...
Read the full Beta-sitosterol monograph →Sources & How We Checked
Meta-Sitosterol 2.0's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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