Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

Meta-Sitosterol 2.0 Ingredients & Drug Interactions

by Metagenics

Tablet Or Pill Category: Fat/fatty Acid
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Meta-Sitosterol 2.0 is a dietary supplement by Metagenics with 6 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,025 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Meta-Sitosterol 2.0 by Metagenics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Meta-Sitosterol 2.0 has 5 active ingredients: folate, beta-sitosterol, campesterol, stigmasterol, and other plant sterols. Beta-sitosterol and its related compounds are plant-derived sterols that support cholesterol metabolism and may help with benign prostate enlargement (BPH).

The product also contains inactive ingredients such as microcrystalline cellulose, croscarmellose sodium, and silica, which act as binders and flow agents in the tablet.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: maintain healthy blood levels and cardiovascular health.
  • We looked for evidence on: Coronary heart disease (CHD), Familial hypercholesterolemia, Hyperlipidemia, Dyslipidemia, Atherosclerosis.
  • The strongest evidence on file: Black Psyllium is rated "Likely Effective" for Coronary heart disease (CHD) (Natural Medicines).
  • Also on file: Beta-sitosterol is rated "Possibly Effective" for Coronary heart disease (CHD), Familial hypercholesterolemia.

Beta-sitosterol in this product is likely effective for benign prostatic hyperplasia (BPH) — the non-cancerous enlargement of the prostate that causes urinary symptoms. It is possibly effective for familial hypercholesterolemia (an inherited condition that raises cholesterol) and coronary heart disease (CHD).

We do not have effectiveness data on file for the other active ingredients in the product.

The evidence, ingredient by ingredient Black Psyllium Beta-sitosterol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-sitosterol is generally well tolerated when taken short-term by most adults. The most common side effects are constipation, diarrhea, gas, indigestion, and nausea.

There are isolated reports of reduced appetite and one case of acute pancreatitis associated with beta-sitosterol use, though symptoms resolved when the user stopped taking it. Beta-sitosterol may worsen acne in some people.

Because there is not enough safety data, it is best to avoid this product during pregnancy and while breastfeeding — talk with your doctor or pharmacist about personalized advice.

Side effects, ingredient by ingredient Black Psyllium Beta-sitosterol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Black Psyllium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2,026 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

No interactions are documented in our data for the ingredients we could check. However, we could not check folate, campesterol, stigmasterol, or other plant sterols.

If you take any medication — especially those affecting cholesterol, fat absorption, or blood clotting — confirm with your doctor or pharmacist before starting this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Meta-Sitosterol 2.0 is a reasonable choice if you're looking to support prostate health or cholesterol levels, since beta-sitosterol is likely effective for BPH. Expect mild digestive side effects like gas or loose stools in some cases.

If you're pregnant, nursing, or take blood thinners or cholesterol drugs, check with your doctor or pharmacist first — we cannot fully rule out interactions with ingredients we could not assess.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Meta-Sitosterol 2.0, straight from the product label.

Brand Metagenics
Barcode (UPC) 755571910660
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 295795
Product type Fat/fatty Acid
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Meta-Sitosterol 2.0 by Metagenics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s), 3 Tablet(s)
Maximum serving Sizes:
1 Tablet(s), 3 Tablet(s)
Servings per container
90
UPC/BARCODE
755571910660
IngredientAmount% DV
Total Carbohydrates0 NP, 1 Gram(s)1%
Folate445 mcg DFE, 1330 mcg DFE111%, 333%
Dietary Fiber0 NP, 1 Gram(s)3%
Beta-Sitosterol333 mg, 1000 mg--
Campesterol167 mg, 500 mg--
Stigmasterol92 mg, 275 mg--
Other Plant Sterols117 mg, 350 mg--

Other ingredients: Plant Sterol Complex, Microcrystalline Cellulose, Croscarmellose Sodium, Cellulose, Stearic Acid, Silica, Calcium L-5-Methyltetrahydrofolate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Meta-Sitosterol 2.0 is a naturally derived vegetable preparation featuring enhanced levels of a balanced concentrate of plant sterols - 2 grams per day - which may help to maintain healthy blood levels already within the normal range. Also features the active, preferred form of folate (L-5-methyltetrahydrofolate) to support healthy homocysteine metabolism and cardiovascular health.

Plant sterol complex for support of healthy cholesterol levels

Formulation

The National Institute of Health recommends a healthy diet, along with the consumption of 2 grams of plant sterols daily, to promote cardiovascular health.

This gluten-free and vegetarian.

This gluten-free and vegetarian.

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Suggested/Recommended/Usage/Directions

Directions: Take one tablet with each meal or as directed by your healthcare practitioner.

Precautions

Caution: Keep out of the reach of children.

Practitioner Exclusive

Contains: Soy.

Storage

Do not refrigerate (Refrigeration may cause moisture condensation)

Seals/Symbols

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administrator. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

As Metafolin, Metafolin is a registered trademark of Merck KGaA, Darmstadt Germany.

See for yourself

Meta-Sitosterol 2.0 by Metagenics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Meta-Sitosterol 2.0 by Metagenics

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Folate

445 mcg DFE per serving

Dietary Fiber

Interacts with
2,025 drugs
0 NP per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Beta-Sitosterol

No known
interactions
333 mg per serving

Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Eviden...

Beta-Sitosterol monograph & interactions

Campesterol

167 mg per serving

Stigmasterol

92 mg per serving

Other Plant Sterols

117 mg per serving

Other (inactive) ingredients: Plant Sterol Complex, Microcrystalline Cellulose, Croscarmellose Sodium, Cellulose, Stearic Acid, Silica, Calcium L-5-Methyltetrahydrofolate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Meta-Sitosterol 2.0 by Metagenics Drug Interactions

Want to check YOUR meds against Meta-Sitosterol 2.0?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
2,025Drugs
23 Moderate 2,002 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Meta-Sitosterol 2.0 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Meta-Sitosterol 2.0, from the product label.

Metagenics

See all Metagenics products
Name
Metagenics
City
Gig Harbor
State
WA
ZipCode
98332
Phone Number
800 692 9400
Web Address
metagenics.com
Pharmacist Counseling Corner

Meta-Sitosterol 2.0 by Metagenics: Common Questions

Does Meta-Sitosterol 2.0 by Metagenics interact with any medications?
Yes. Based on its ingredients, Meta-Sitosterol 2.0 has a known interaction with 2,025 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Meta-Sitosterol 2.0 contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does beta-sitosterol really help with an enlarged prostate?
Yes — beta-sitosterol in this product is likely effective for benign prostatic hyperplasia (BPH), the non-cancerous prostate enlargement that causes trouble urinating. It's one of the more solid uses for plant sterols.
Will this help my cholesterol?
Beta-sitosterol is possibly effective for familial hypercholesterolemia (an inherited high-cholesterol condition) and possibly effective for coronary heart disease. If your cholesterol is just mildly high, the evidence is weaker — check with your doctor about whether this fits your situation.
What side effects should I expect?
Most people tolerate it well, but some experience constipation, diarrhea, gas, indigestion, nausea, or reduced appetite. There's also a small chance it could worsen acne. Start with the dose on the bottle and dial back if your digestion gets upset.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data to know either way, so it's best to avoid it during pregnancy and breastfeeding. Talk with your doctor or pharmacist about what's right for your situation.
What's folate doing in here?
Folate supports general cell health and energy metabolism. It's a B vitamin, and the form in this product is a synthetic, active version called L-5-methyltetrahydrofolate that your body can use right away.
Are the other plant sterols (campesterol, stigmasterol) as well-studied as beta-sitosterol?
We don't have effectiveness data on file for those ingredients specifically. Beta-sitosterol is the most researched of the plant sterols in prostate and cholesterol support, which is likely why it's highlighted.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Meta-Sitosterol 2.0 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Meta-Sitosterol 2.0 label
Sources

Sources & How We Checked

Meta-Sitosterol 2.0's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Beta-sitosterol 7 references
  1. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
  2. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
  3. Wilt TJ, MacDonald R, Ishani A. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int 1999;83:976-83. PubMed
  4. Oster P, Schlierf G, Heuck CC, et al. [Sitosterol in familial hyperlipoproteinemia type II. A randomized, double-blind, cross-over study]. Dtsch Med Wochenschr 1976;101:1308-11.
  5. Becker M, Staab D, Von Bergman K. Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate. Pediatrics 1992;89:138-42. DOI
  6. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  7. Lorenze A, Hsueh W, Nasr J. Beta-sitosterol-induced acute pancreatitis: A case report and review of the literature. Cureus. 2020;12(3):e7407. PubMed

See these in context on the Beta-sitosterol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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