Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Monocombo Ingredients & Drug Interactions

by Ecological Formulas

Monocombo label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Monocombo against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Monocombo is a dietary supplement by Ecological Formulas with 4 active ingredients. Its ingredients are commonly taken for immune support, viral infections (such as herpes or colds), antibacterial support.Based on those ingredients, 280 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ivy Leaf Extract . Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Monocombo by Ecological Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Monocombo by Ecological Formulas — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Monocombo by Ecological Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Monocombo has four ingredients: Monolaurin, Ivy Leaf Extract, Lysozyme Hydrochloride, and Polylysine Hydrochloride. Monolaurin is a fatty acid related to compounds in coconut oil.

Ivy Leaf Extract comes from the English ivy plant. Lysozyme and Polylysine are proteins.

The capsule also contains inactive ingredients—gelatin, microcrystalline cellulose, silicon dioxide, and magnesium stearate—which are standard binders and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: broad-spectrum immune and respiratory support.
  • We looked for evidence on: Bronchitis, Cough, Respiratory tract infections, Viral infections, Immune function, Antimicrobial support.
  • The closest evidence on file: English Ivy is rated "Insufficient Reliable Evidence To Rate" for Bronchitis (Natural Medicines).
  • Also on file: English Ivy is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Cough.

The evidence for Monocombo's ingredients is limited. For Monolaurin against bacterial vaginosis, the data we hold shows insufficient reliable evidence to rate it.

The Ivy Leaf Extract has been studied for bronchitis, respiratory tract infections, gout, spasticity, and neuropathic pain, but in each case the data shows insufficient reliable evidence to rate effectiveness. We don't have effectiveness ratings on file for Lysozyme or Polylysine.

If you're considering this product for a specific condition, talk with your pharmacist or doctor about what the current evidence actually supports.

The evidence, ingredient by ingredient Monolaurin English Ivy

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ivy Leaf Extract in standardized form is generally well tolerated, but the raw plant is toxic. When taken by mouth, the extract may cause abdominal pain, diarrhea, nausea, and vomiting in some people.

Monolaurin is often well tolerated in food-related amounts, but supplement safety in humans hasn't been well studied. Regarding pregnancy: Monolaurin has not enough safety data and should be avoided during pregnancy.

Ivy Leaf Extract also has not enough reliable safety data and is best avoided in pregnancy. For breastfeeding, Monolaurin's supplement safety is unknown (though lauric acid occurs naturally in breast milk), so use caution and ask your doctor.

Ivy Leaf Extract safety while breastfeeding is unknown and should be avoided unless your doctor directs otherwise.

Side effects, ingredient by ingredient Monolaurin English Ivy

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — English Ivy.
  • The most serious interaction on file is rated Moderate.
  • For scale: 280 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Monocombo, check your medications against CYP2C19, CYP2D6, and CYP2C8 substrates—Moderate-severity interactions from the Ivy Leaf Extract. These pathways include drugs for depression, heart rhythm, blood clotting, pain, and many others.

Use the medication checker on this page with your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Monocombo may appeal to someone looking for natural immune or wellness support, but the evidence for its ingredients' effectiveness is insufficient to rate. More important: the Ivy Leaf Extract can interact with a large number of common medications by changing how your liver processes them.

Before you take it, check your exact medications with the tool on this page, and talk with your pharmacist about whether this product makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Monocombo, straight from the product label.

Brand Ecological Formulas
Barcode (UPC) 787790946083
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 299795
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Monocombo by Ecological Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
787790946083
IngredientAmount% DV
Monolaurin300 mg--
Ivy Leaf Extract 50 mg--
Lysozyme Hydrochloride1 mg--
Polylysine Hydrochloride150 mcg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formulation

Monocombo is a scientifically designed nutritional supplement containing a range of physiologic adjuvants known for their synergistic properties.

Free of corn, yeast, wheat and dairy products.

Adjuvir Broad-spectrum

Suggested/Recommended/Usage/Directions

Directions Take one capsule daily, or more as directed by a physician.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Contains: Egg

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Monocombo by Ecological Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Monocombo label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Monocombo by Ecological Formulas

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Monolaurin

No known
interactions
300 mg per serving

Monolaurin is a compound made from lauric acid, a fatty acid found in coconut oil and breast milk, and it is marketed mostly for immune and antimicrob...

Monolaurin monograph & interactions

Ivy Leaf Extract

Interacts with
280 drugs
50 mg per serving Form: Hederacoside

English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many...

Ivy Leaf Extract monograph & interactions

Lysozyme Hydrochloride

1 mg per serving

Polylysine Hydrochloride

150 mcg per serving

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Monocombo by Ecological Formulas Drug Interactions

Want to check YOUR meds against Monocombo?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
280Drugs
280 Moderate

Ingredients driving the most interactions

Ivy Leaf Extract 280

Individual Drug Interactions

The ingredients in Monocombo interact with 280 drugs. Click any drug to see the details.

1 of the 4 ingredients in Monocombo interact with drugs. Each result below shows which ingredient is responsible. Ivy Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Monocombo with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ivy Leaf Extract 3 drug types · 280 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.
In vitro research shows that English ivy inhibits CYP2C19 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C8.
In vitro research shows that English ivy inhibits CYP2C8 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
In vitro research shows that English ivy inhibits CYP2D6 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Ivy Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Monocombo, from the product label.

Ecological Formulas

See all Ecological Formulas products
Name
Ecological Formulas
Street Address
1061-B Shary Circle
City
Concord
State
CA
ZipCode
94518
Pharmacist Counseling Corner

Monocombo by Ecological Formulas: Common Questions

Does Monocombo by Ecological Formulas interact with any medications?
Yes. Based on its ingredients, Monocombo has a known interaction with 280 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Monocombo contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Monolaurin safe during pregnancy?
No. There is not enough safety data, so it's best to avoid Monolaurin during pregnancy. Talk with your doctor before taking this product if you're pregnant or planning to become pregnant.
Can I take Monocombo while breastfeeding?
It's complicated. Monolaurin's safety while breastfeeding is unknown, so use caution and ask your doctor. The Ivy Leaf Extract should be avoided while breastfeeding unless your doctor directs otherwise. This is a conversation to have with your doctor or pharmacist before starting.
What are the most common side effects of Ivy Leaf Extract?
When taken by mouth, the most common side effects are abdominal pain, diarrhea, nausea, and vomiting. Some people may also experience skin irritation. These tend to occur in a small number of users, but if you notice any of these, stop taking it and talk with your pharmacist.
Does Monocombo work for bacterial vaginosis?
The evidence we hold for Monolaurin against bacterial vaginosis is insufficient to rate. That means we don't have enough reliable data to say whether it works. If you're treating a vaginal infection, talk with your doctor about proven options first.
What is Lysozyme Hydrochloride, and does it interact with medications?
Lysozyme Hydrochloride is a protein ingredient in this product. We don't hold interaction data for it, so we're unable to check whether it interacts with your medications. If you're concerned about a specific drug you take, ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Monocombo label
Go deeper

The Full Monographs Behind Monocombo’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Monolaurin

Monolaurin is a compound made from lauric acid, a fatty acid found in coconut oil and breast milk, and it is marketed mostly for immune and antimicrobial support. While laboratory studies su...

Read the full Monolaurin monograph → Herb & supplement monograph

English Ivy

Interacts with 280 drugs

English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many European herbal products. Some research...

Read the full English Ivy monograph →
Sources

Sources & How We Checked

Monocombo's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Monolaurin 2 references
  1. FDA, Center for Food Safety and Applied Nutrition, Office of Premarket Approval, EAFUS: A food additive database. Website: vm.cfsan.fda.gov/~dms/eafus.html (Accessed 23 February 2006).
  2. Mancuso AC, Widdice LE, Hughes BL, et al. Five Percent Monolaurin Vaginal Gel for the Treatment of Bacterial Vaginosis: A Randomized Placebo-Controlled Trial. J Low Genit Tract Dis. 2020 Jul;24(3):277-283. PubMed

See these in context on the Monolaurin monograph →

English Ivy 13 references
  1. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  2. Fazio S, Pouso J, Dolinsky D, et al. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine 2009;16 PubMed
  3. García M, Fernández E, Navarro JA, et al. Allergic contact dermatitis from Hedera helix L. Contact Dermatitis 1995;33(2):133-4.
  4. Hausen BM, Brohan J, Konig WA, et al. Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.). Contact Dermatitis 1987;17(1):1-9.
  5. Mitchell, J. C. Allergic contact dermatitis from Hedera helix and Brassaia actinophylla (Araliaceae). Contact Dermatitis 1981;7(3):158-159.
  6. Boyle J, Harman RM. Contact dermatitis to Hedera helix (common ivy). Contact Dermatitis 1985;12(2):111-112. PubMed
  7. Yesudian PD, Franks A. Contact dermatitis from Hedera helix in a husband and wife. Contact Dermatitis 2002;46(2):125-126.
  8. Bregnbak D, Menné T, Johansen JD. Airborne contact dermatitis caused by common ivy (Hedera helix L. ssp. helix). Contact Dermatitis. 2015;72(4):243-4.
  9. Jones JM, White IR, White JM, McFadden JP. Allergic contact dermatitis to English ivy (Hedera helix)--a case series. Contact Dermatitis. 2009 Mar;60(3):179-80.
  10. Lurquin E, Swinnen I, Goossens A. Allergic contact dermatitis caused by Hedera helix arborescens and not by Hedera helix L. Contact Dermatitis. 2012;66(6):352-3.
  11. Paulsen E, Christensen LP, Andersen KE. Dermatitis from common ivy (Hedera helix L. subsp. helix) in Europe: past, present, and future. Contact Dermatitis. 2010;62(4):201-9.
  12. Rehman SU, Kim IS, Choi MS, Kim SH, Zhang Y, Yoo HH. Time-dependent Inhibition of CYP2C8 and CYP2C19 by Hedera helix Extracts, A Traditional Respiratory Herbal Medicine. Molecules. 2017;22(7). PubMed
  13. Kruttschnitt E, Wegener T, Zahner C, Henzen-Bücking S. Assessment of the Efficacy and Safety of Ivy Leaf (Hedera helix) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis. Evid Based Complement Alternat Med. 2020 May 4;2

See these in context on the English Ivy monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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