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Dietary supplement

MSM, Glucosamine & Chondroitin Plus Ingredients & Drug Interactions

by Kala Health

MSM, Glucosamine & Chondroitin Plus label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MSM, Glucosamine & Chondroitin Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MSM, Glucosamine & Chondroitin Plus is a dietary supplement by Kala Health with 6 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, joint stiffness, cartilage support.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are ChondroPure. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against MSM, Glucosamine & Chondroitin Plus by Kala Health

Ask about any prescription or over-the-counter medication and we check it for interactions with MSM, Glucosamine & Chondroitin Plus by Kala Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of MSM, Glucosamine & Chondroitin Plus by Kala Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 6 active ingredients designed to support joint and connective tissue health. The three main ones are OptiMSM (a branded form of methylsulfonylmethane, a sulfur compound), GlucosaGreen (a branded glucosamine source), and ChondroPure (chondroitin sulfate, a component of cartilage).

You'll also get Ester-C (a form of vitamin C), Aquamin (a mineral source), and B-2Cool (a branded ingredient). Several inactive ingredients — including collagen type II and additional minerals — are also present to round out the formula.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Joint health and cartilage support.
  • We looked for evidence on: Osteoarthritis, Aromatase inhibitor-induced arthralgia, Kashin-Beck disease, Temporomandibular disorders (TMD), Joint pain, Joint stiffness — and 2 related terms.
  • The strongest evidence on file: Chondroitin Sulfate is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Chondroitin Sulfate is rated "Insufficient Reliable Evidence To Rate" for Temporomandibular disorders (TMD), Kashin-Beck disease, Aromatase inhibitor-induced arthralgia.

Chondroitin sulfate, the ingredient we have effectiveness data for, is rated possibly effective for cataracts and osteoarthritis based on the evidence we hold. For aging skin, osteoporosis, high cholesterol (hyperlipidemia), and colorectal adenomas, the evidence is insufficient to make a reliable rating.

We don't have effectiveness data on file for the other branded ingredients in this product.

The evidence, ingredient by ingredient Chondroitin Sulfate

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chondroitin sulfate is generally well tolerated for short-term use, though quality varies and benefit is uncertain. The most common side effects from oral use are digestive — abdominal pain, bloating, constipation, diarrhea, heartburn, and nausea.

Rare but serious liver damage has been reported. Skin reactions like eyelid swelling, limb swelling, hair loss, rash, hives, and water retention around the eyes have occurred, especially in combinations with glucosamine.

One person experienced worsening asthma, and one case of sun sensitivity was reported and reproduced on rechallenge. For pregnancy, the safety data advises against use due to insufficient information.

The same applies to breastfeeding — do not use without talking to your doctor or pharmacist first.

Side effects, ingredient by ingredient Chondroitin Sulfate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Chondroitin Sulfate.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or another blood thinner, check with us before using this product — chondroitin may increase bleeding risk. We could not check the other branded ingredients in this formula for medication interactions, so run your exact medications through the search tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is geared toward anyone looking to support joint health, particularly for osteoarthritis. If you take warfarin or any blood thinner, check with your pharmacist or doctor before starting — the chondroitin in this formula may affect how your medication works.

If you're pregnant or breastfeeding, avoid it until you've spoken with your healthcare provider. Digestive upset and skin reactions are possible, so watch for those.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MSM, Glucosamine & Chondroitin Plus, straight from the product label.

Brand Kala Health
Barcode (UPC) 8719322755711
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 311320
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MSM, Glucosamine & Chondroitin Plus by Kala Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
8719322755711
IngredientAmount% DV
OptiMSM600 mg--
GlucosaGreen450 mg--
ChondroPure400 mg--
Ester-C120 mg150%
Aquamin100 mg--
B-2Cool30 mg--

Other ingredients: Methylsulfonylmethane, Glucosamine, Chondroitin, Vitamin C, Minerals, Trace Elements, Collagen Type II, Undenatured, Hydroxypropylmethylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

%RI= EU Reference-Intake

Formula

This extraordinary formula contains a sophisticated mix of high-quality Branded ingredients, with positive health effect backed up by scientific evidence. Especially the combination with undernatured collagen type II, provides unprecedented strong improvement of the natural movement. Ocean Water Concentrate is a rich source of all more than 70 minerals and trace elements found in nature, and essential to general health.

Food Supplement, contain MSM, vegetarian Glucosamine, Chondroitin, Vitamins, Minerals and Collagen.

MSM, Glucosamine & Chondroitin Plus with undenatured Collagen Type II

Storage

Storage: Store in a dark, dry place, out of reach of young children.

Precautions

Storage: Store in a dark, dry place, out of reach of young children.

A Food Supplement should not be used as a substitute for a varied diet.

Do not exceed the recommended dosage.

Suggested/Recommended/Usage/Directions

Recommended dosage: Take 1 capsule twice daily, or as recommended. Best taken with meals. Do not exceed the recommended dosage.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MSM, Glucosamine & Chondroitin Plus by Kala Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MSM, Glucosamine & Chondroitin Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MSM, Glucosamine & Chondroitin Plus by Kala Health

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

OptiMSM

600 mg per serving Form: Methylsulfonylmethane

GlucosaGreen

450 mg per serving Form: Glucosamine Hydrochloride

ChondroPure

Interacts with
2 drugs
400 mg per serving Form: Chondroitin Sulfate

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain....

ChondroPure monograph & interactions

Ester-C

120 mg per serving Form: Vitamin C

Aquamin

100 mg per serving Form: Ocean Water Concentrate

B-2Cool

30 mg per serving Form: Collagen Type II, Undenatured

Other (inactive) ingredients: Methylsulfonylmethane, Glucosamine, Chondroitin, Vitamin C, Minerals, Trace Elements, Collagen Type II, Undenatured, Hydroxypropylmethylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

MSM, Glucosamine & Chondroitin Plus by Kala Health Drug Interactions

Want to check YOUR meds against MSM, Glucosamine & Chondroitin Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

ChondroPure 2

Individual Drug Interactions

The ingredients in MSM, Glucosamine & Chondroitin Plus interact with 2 drugs. Click any drug to see the details.

1 of the 6 ingredients in MSM, Glucosamine & Chondroitin Plus interact with drugs. Each result below shows which ingredient is responsible. ChondroPure

Each ingredient & the kinds of drugs it affects

For each ingredient in MSM, Glucosamine & Chondroitin Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

ChondroPure1 drug type · 2 drugs

Warfarin (Coumadin)

Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin. However, the effect of chondroitin alone is unclear.
There have been multiple reports of increased international normalized ratio (INR) in patients taking warfarin with glucosamine, with or without chondroitin. The lack of reports with chondroitin alone seem to suggest that the interactions occurring in these reports may have been due to glucosamine. In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in INR in patients previously stabilized on warfarin. Additionally, 20 voluntary case reports to the US Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone, without chondroitin, to increased INR in patients taking warfarin.

Likelihood Unlikely Evidence D
ChondroPure full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MSM, Glucosamine & Chondroitin Plus, from the product label.

Kala Health

See all Kala Health products
Name
Kala Health BV- NL
Web Address
www.kalahealth.eu
Pharmacist Counseling Corner

MSM, Glucosamine & Chondroitin Plus by Kala Health: Common Questions

Does MSM, Glucosamine & Chondroitin Plus by Kala Health interact with any medications?
Yes. Based on its ingredients, MSM, Glucosamine & Chondroitin Plus has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MSM, Glucosamine & Chondroitin Plus contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my osteoarthritis?
Chondroitin sulfate, one of the main ingredients, is rated possibly effective for osteoarthritis based on the evidence we have. That means some research supports it, but the evidence isn't conclusive. Results vary from person to person.
What are the most common side effects?
Digestive issues are most common — bloating, diarrhea, constipation, nausea, heartburn, and abdominal pain. Skin reactions like rash, swelling, and hives have also been reported, especially in combination products. Rare cases of liver damage and asthma worsening have been documented.
Is it safe to take while pregnant?
No. The safety data for chondroitin sulfate advises against use during pregnancy because there isn't enough information to know it's safe. Talk to your doctor or pharmacist about what's right for you.
Can I take this while breastfeeding?
The safety information is insufficient, so it's best to avoid it while breastfeeding. Speak with your doctor or pharmacist first to make sure it's okay for your situation.
What does chondroitin actually do?
Chondroitin is a natural component of cartilage. In this product, it's intended to support joint structure and function, particularly for conditions like osteoarthritis and cataracts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if MSM, Glucosamine & Chondroitin Plus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MSM, Glucosamine & Chondroitin Plus label
Go deeper

The Full Monographs Behind MSM, Glucosamine & Chondroitin Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chondroitin Sulfate

Interacts with 2 drugs

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...

Read the full Chondroitin Sulfate monograph →
Sources

Sources & How We Checked

MSM, Glucosamine & Chondroitin Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chondroitin Sulfate 22 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  3. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  4. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  5. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
  6. Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
  7. Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
  8. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
  9. Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
  10. Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
  11. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
  12. Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
  13. Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
  14. Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
  15. Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
  16. Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
  17. von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
  18. Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
  19. Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
  20. Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
  21. Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
  22. Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed

See these in context on the Chondroitin Sulfate monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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